Manipulating the mouse genome to engineer precise functional syntenic replacements with human sequence.
about
Refined human artificial chromosome vectors for gene therapy and animal transgenesisThe mammalian gene function resource: the International Knockout Mouse ConsortiumThe complexity of epigenetic diseasesLarge-scale chromatin organization: the good, the surprising, and the still perplexingAn organized and functional thymus generated from FOXN1-reprogrammed fibroblastsDevelopmental and species-divergent globin switching are driven by BCL11AAn interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitmentMosaic complementation demonstrates a regulatory role for myosin VIIa in actin dynamics of stereociliaThe expanding role of mouse genetics for understanding human biology and diseaseChromosomal manipulation by site-specific recombinases and fluorescent protein-based vectors.Adventitious changes in long-range gene expression caused by polymorphic structural variation and promoter competitionEfficient gene targeting by homologous recombination in rat embryonic stem cellsEvolution of hemoglobin and its genesModelling human regulatory variation in mouse: finding the function in genome-wide association studies and whole-genome sequencingA BAC-based transgenic mouse specifically expresses an inducible Cre in the urothelium.High efficiency of a sequential recombinase-mediated cassette exchange reaction in Escherichia coli.Phenotypic impact of genomic structural variation: insights from and for human disease.Analysis of hundreds of cis-regulatory landscapes at high resolution in a single, high-throughput experiment.Regeneration of the aged thymus by a single transcription factor.Association between active genes occurs at nuclear speckles and is modulated by chromatin environment.Polycomb eviction as a new distant enhancer function.New approaches to the representation and analysis of phenotype knowledge in human diseases and their animal modelsUncovering enhancer functions using the α-globin locus.Mouse slc9a8 mutants exhibit retinal defects due to retinal pigmented epithelium dysfunction.Redesign of the monomer-monomer interface of Cre recombinase yields an obligate heterotetrameric complex.Genome engineering: Drosophila melanogaster and beyondGenomically humanized mice: technologies and promises.Stella-Cre mice are highly efficient Cre deleters.High-resolution analysis of cis-acting regulatory networks at the α-globin locus.PiggyBac transposon-based polyadenylation-signal trap for genome-wide mutagenesis in mice.Efficient generation of large-scale genome-modified mice using gRNA and CAS9 endonuclease.Studying human telomerase gene transcription by a chromatinized reporter generated by recombinase-mediated targeting of a bacterial artificial chromosome.BRG1 directly regulates nucleosome structure and chromatin looping of the alpha globin locus to activate transcription.Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes.Metabolic and molecular insights into an essential role of nicotinamide phosphoribosyltransferase.Recent advances in gene manipulation and nicotinic acetylcholine receptor biology.Resurrecting ancient animal genomes: the extinct moa and more.Computational tools for comparative phenomics: the role and promise of ontologies.Targeted mutagenesis tools for modelling psychiatric disorders.Understanding α-globin gene regulation and implications for the treatment of β-thalassemia.
P2860
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P2860
Manipulating the mouse genome to engineer precise functional syntenic replacements with human sequence.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh-hant
name
Manipulating the mouse genome ...... lacements with human sequence.
@en
Manipulating the mouse genome ...... lacements with human sequence.
@nl
type
label
Manipulating the mouse genome ...... lacements with human sequence.
@en
Manipulating the mouse genome ...... lacements with human sequence.
@nl
prefLabel
Manipulating the mouse genome ...... lacements with human sequence.
@en
Manipulating the mouse genome ...... lacements with human sequence.
@nl
P2093
P1433
P1476
Manipulating the mouse genome ...... lacements with human sequence.
@en
P2093
Andrew J H Smith
Fatima Marques-Kranc
Francisco Luna-Crespo
Helen A C Wallace
Jackie A Sharpe
Jim Hughes
Melville Richardson
William G Wood
P304
P356
10.1016/J.CELL.2006.11.044
P407
P577
2007-01-01T00:00:00Z