Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis. - Wikidata - awgldk - TriplyDB

Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis.

Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis.

http://www.wikidata.org/entity/Q53265449

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Protein phosphatase 2A dysfunction in Alzheimer's disease Therapeutic benefits of a component of coffee in a rat model of Alzheimer's disease.Phosphoprotein phosphatase 2A: a novel druggable target for Alzheimer's disease Neuroprotective and anti-inflammatory properties of a coffee component in the MPTP model of Parkinson's disease Protein phosphatases and Alzheimer's disease The biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificity Circumventing embryonic lethality with Lcmt1 deficiency: generation of hypomorphic Lcmt1 mice with reduced protein phosphatase 2A methyltransferase expression and defects in insulin signaling The structural basis for tight control of PP2A methylation and function by LCMT-1.Silencing PP2A inhibitor by lenti-shRNA interference ameliorates neuropathologies and memory deficits in tg2576 mice.Genetic variation in the tau protein phosphatase-2A pathway is not associated with Alzheimer's disease risk.Role of protein phosphatases and mitochondria in the neuroprotective effects of estrogens.Cytoplasmic SET induces tau hyperphosphorylation through a decrease of methylated phosphatase 2A.Interaction between salt-inducible kinase 2 and protein phosphatase 2A regulates the activity of calcium/calmodulin-dependent protein kinase I and protein phosphatase methylesterase-1.Altered protein phosphatase 2A methylation and Tau phosphorylation in the young and aged brain of methylenetetrahydrofolate reductase (MTHFR) deficient mice.Epigenomics of Alzheimer's disease.Ferulic acid attenuates the injury-induced decrease of protein phosphatase 2A subunit B in ischemic brain injury Phenylarsine oxide binding reveals redox-active and potential regulatory vicinal thiols on the catalytic subunit of protein phosphatase 2A.Up-regulation of inhibitors of protein phosphatase-2A in Alzheimer's disease.Tau is hyperphosphorylated at multiple sites in mouse brain in vivo after streptozotocin-induced insulin deficiency The protein phosphatase PP2A/Bα binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn: implications for tauopathies.Curcumin treatment recovery the decrease of protein phosphatase 2A subunit B induced by focal cerebral ischemia in Sprague-Dawley rats Acute administration of L-DOPA induces changes in methylation metabolites, reduced protein phosphatase 2A methylation, and hyperphosphorylation of Tau protein in mouse brain.Bridging the gap between protein carboxyl methylation and phospholipid methylation to understand glucose-stimulated insulin secretion from the pancreatic beta cell.Connecting cell-cycle activation to neurodegeneration in Drosophila.PP2A methylation controls sensitivity and resistance to β-amyloid-induced cognitive and electrophysiological impairments.GBA deficiency promotes SNCA/α-synuclein accumulation through autophagic inhibition by inactivated PPP2A.Protein phosphatase 2A contributes to the cardiac dysfunction induced by endotoxemia.Leucine carboxyl methyltransferase 1 (LCMT1)-dependent methylation regulates the association of protein phosphatase 2A and Tau protein with plasma membrane microdomains in neuroblastoma cells Physiological regulation of tau phosphorylation during hibernation Enhanced phosphatase activity attenuates α-synucleinopathy in a mouse model Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology Dysregulation of protein phosphatase 2A in parkinson disease and dementia with lewy bodies.Roles of phosphotase 2A in nociceptive signal processing.Tau as a therapeutic target for Alzheimer's disease Molecular and cellular mechanism of okadaic acid (OKA)-induced neurotoxicity: a novel tool for Alzheimer's disease therapeutic application.Effect of Pin1 or microtubule binding on dephosphorylation of FTDP-17 mutant Tau GSK-3β is Dephosphorylated by PP2A in a Leu309 Methylation-Independent Manner.Polymeric alkylpyridinium salts permit intracellular delivery of human Tau in rat hippocampal neurons: requirement of Tau phosphorylation for functional deficits.Cytoskeleton as a Target of Quinolinic Acid Neurotoxicity: Insight from Animal Models.Regulation of protein phosphatase 2A methylation by LCMT1 and PME-1 plays a critical role in differentiation of neuroblastoma cells

P2860

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P2860

Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis.

http://www.wikidata.org/entity/Q53265449

description

2004 nî lūn-bûn

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2004年の論文

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年學術文章

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2004年學術文章

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name

Downregulation of protein phos ...... lzheimer disease pathogenesis.

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Downregulation of protein phos ...... lzheimer disease pathogenesis.

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type

label

Downregulation of protein phos ...... lzheimer disease pathogenesis.

@en

Downregulation of protein phos ...... lzheimer disease pathogenesis.

@nl

prefLabel

Downregulation of protein phos ...... lzheimer disease pathogenesis.

@en

Downregulation of protein phos ...... lzheimer disease pathogenesis.

@nl

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P1433

Journal of Neuropathology & Experimental Neurology

P1476

Downregulation of protein phos ...... Alzheimer disease pathogenesis

@en

P2093

Ampa Luangpirom

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Christa Hladik

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Estelle Sontag

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Ingrid Mudrak

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Lisa Montgomery

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P2860

A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A

Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue

Carboxyl methylation regulates phosphoprotein phosphatase 2A by controlling the association of regulatory B subunits

Carboxyl methylation of the phosphoprotein phosphatase 2A catalytic subunit promotes its functional association with regulatory subunits in vivo

A specific protein carboxyl methylesterase that demethylates phosphoprotein phosphatase 2A in bovine brain

Differential methylation and altered conformation of cytoplasmic and nuclear forms of protein phosphatase 2A during cell cycle progression

Structure of protein phosphatase methyltransferase 1 (PPM1), a leucine carboxyl methyltransferase involved in the regulation of protein phosphatase 2A activity

Carboxymethylation of the PP2A catalytic subunit in Saccharomyces cerevisiae is required for efficient interaction with the B-type subunits Cdc55p and Rts1p

SAM (dependent) I AM: the S-adenosylmethionine-dependent methyltransferase fold

Flicking the switches: phosphorylation of serine/threonine protein phosphatases.

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1080-1091

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scholarly article

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10

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63

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Charles L White

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8186060

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15535135

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