The structural integrity of anion binding exosite I of thrombin is required and sufficient for timely cleavage and activation of factor V and factor VIII.

The structural integrity of anion binding exosite I of thrombin is required and sufficient for timely cleavage and activation of factor V and factor VIII.

Item
http://www.wikidata.org/entity/Q53626760
Structural basis of thrombin-mediated factor V activation: the Glu666-Glu672 sequence is critical for processing at the heavy chain-B domain junctionContribution of Amino Acid Region 659−663 of Factor Va Heavy Chain to the Activity of Factor Xa within Prothrombinase,The molecular basis of factor V and VIII procofactor activationThe Importance of Exosite Interactions for Substrate Cleavage by Human Thrombin.The role of thrombin exosites I and II in the activation of human coagulation factor V.Expression of allosteric linkage between the sodium ion binding site and exosite I of thrombin during prothrombin activation.Exosites in the substrate specificity of blood coagulation reactions.The Dual Regulatory Role of Amino Acids Leu480 and Gln481 of Prothrombin.Exploring potential anticoagulant drug formulations using thrombin generation test.Role of the acidic hirudin-like COOH-terminal amino acid region of factor Va heavy chain in the enhanced function of prothrombinase.Cooperative regulation of the activity of factor Xa within prothrombinase by discrete amino acid regions from factor Va heavy chain.Limiting prothrombin activation to meizothrombin is compatible with survival but significantly alters hemostasis in mice.Spellbinding Effects of the Acidic COOH-Terminus of Factor Va Heavy Chain on Prothrombinase Activity and Function.
P2860

The structural integrity of anion binding exosite I of thrombin is required and sufficient for timely cleavage and activation of factor V and factor VIII.

Item
http://www.wikidata.org/entity/Q53626760
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2006 nî lūn-bûn
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2006年の論文
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2006年学术文章
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2006年学术文章
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name
The structural integrity of an ...... n of factor V and factor VIII.
@en
The structural integrity of an ...... n of factor V and factor VIII.
@nl
type
label
The structural integrity of an ...... n of factor V and factor VIII.
@en
The structural integrity of an ...... n of factor V and factor VIII.
@nl
prefLabel
The structural integrity of an ...... n of factor V and factor VIII.
@en
The structural integrity of an ...... n of factor V and factor VIII.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P356
P1433
P1476
The structural integrity of an ...... n of factor V and factor VIII.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698