Autoimmune disease in Lyn-deficient mice is dependent on an inflammatory environment established by IL-6.
about
Targeted therapeutics in SLE: emerging strategies to modulate the interferon pathwayPathogenic Inflammation and Its Therapeutic Targeting in Systemic Lupus ErythematosusSelective APRIL blockade delays systemic lupus erythematosus in mouse.A balance between B cell receptor and inhibitory receptor signaling controls plasma cell differentiation by maintaining optimal Ets1 levelsRequirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient miceMyeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice.Interleukin 6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica.B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice.Mice overexpressing BAFF develop a commensal flora-dependent, IgA-associated nephropathy.IL-6 contributes to an immune tolerance checkpoint in post germinal center B cells.Genetic Interaction between Lyn, Ets1, and Btk in the Control of Antibody Levels.Functions of the Lyn tyrosine kinase in health and diseaseIL-21 promotes the production of anti-DNA IgG but is dispensable for kidney damage in lyn-/- mice.B cell-specific loss of Lyn kinase leads to autoimmunityBAFF/BLyS inhibitors: A new prospect for treatment of systemic lupus erythematosus.The pathophysiology of preeclampsia involves altered levels of angiogenic factors promoted by hypoxia and autoantibody-mediated mechanisms.Tyrosine kinases in rheumatoid arthritis.Severe Developmental B Lymphopoietic Defects in Foxp3-Deficient Mice are Refractory to Adoptive Regulatory T Cell Therapy.Activated basophils give lupus a booster shot.The tyrosine kinase Lyn limits the cytokine responsiveness of plasma cells to restrict their accumulation in mice.Cutting-edge issues in organ-specific autoimmunity.Glucocorticoid-induced leucine zipper (GILZ) inhibits B cell activation in systemic lupus erythematosus.Bruton's Tyrosine Kinase, a Component of B Cell Signaling Pathways, Has Multiple Roles in the Pathogenesis of Lupus.Manipulation of B-cell responses with histone deacetylase inhibitors.Lyn, Lupus, and (B) Lymphocytes, a Lesson on the Critical Balance of Kinase Signaling in Immunity.Lyn prevents aberrant inflammatory responses to infection in mammalian systems by repressing a SHIP-1-associated signaling cluster
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P2860
Autoimmune disease in Lyn-deficient mice is dependent on an inflammatory environment established by IL-6.
description
2009 nî lūn-bûn
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2009年の論文
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2009年学术文章
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2009年学术文章
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2009年学术文章
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2009年学术文章
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2009年学术文章
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name
Autoimmune disease in Lyn-defi ...... vironment established by IL-6.
@en
Autoimmune disease in Lyn-defi ...... vironment established by IL-6.
@nl
type
label
Autoimmune disease in Lyn-defi ...... vironment established by IL-6.
@en
Autoimmune disease in Lyn-defi ...... vironment established by IL-6.
@nl
prefLabel
Autoimmune disease in Lyn-defi ...... vironment established by IL-6.
@en
Autoimmune disease in Lyn-defi ...... vironment established by IL-6.
@nl
P2093
P356
P1476
Autoimmune disease in Lyn-defi ...... vironment established by IL-6.
@en
P2093
Cathy Quilici
David M Tarlinton
Evelyn Tsantikos
Gary P Anderson
Margaret L Hibbs
Sarah A Oracki
P304
P356
10.4049/JIMMUNOL.0901878
P407
P577
2009-12-30T00:00:00Z