The Enzymatic Core of the Parkinson’s Disease-Associated Protein LRRK2 Impairs Mitochondrial Biogenesis in Aging Yeast.

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The Enzymatic Core of the Parkinson’s Disease-Associated Protein LRRK2 Impairs Mitochondrial Biogenesis in Aging Yeast.

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2018 nî lūn-bûn

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2018年の論文

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2018年学术文章

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2018年学术文章

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2018年学术文章

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2018年学术文章

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2018年学术文章

@zh-sg

2018年學術文章

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2018年學術文章

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2018年學術文章

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name

The Enzymatic Core of the Park ...... ial Biogenesis in Aging Yeast.

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The Enzymatic Core of the Park ...... ial Biogenesis in Aging Yeast.

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Item

label

The Enzymatic Core of the Park ...... ial Biogenesis in Aging Yeast.

@en

The Enzymatic Core of the Park ...... ial Biogenesis in Aging Yeast.

@nl

prefLabel

The Enzymatic Core of the Park ...... ial Biogenesis in Aging Yeast.

@en

The Enzymatic Core of the Park ...... ial Biogenesis in Aging Yeast.

@nl

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The Enzymatic Core of the Park ...... rial Biogenesis in Aging Yeast

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P2093

Corvin Walter

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F-Nora Vögtle

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Heimo Wolinski

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Lukas Habernig

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Sergi Tosal-Castano

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Walter Keller

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P2860

Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation

GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2

Membrane localization of LRRK2 is associated with increased formation of the highly active LRRK2 dimer and changes in its phosphorylation

Mutant LRRK2 toxicity in neurons depends on LRRK2 levels and synuclein but not kinase activity or inclusion bodies

Localization of LRRK2 to membranous and vesicular structures in mammalian brain

G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization

Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease.

The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease

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205

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scholarly article

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10.3389/FNMOL.2018.00205

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P478

http://www.w3.org/2001/XMLSchema#string

P50

Andreas Aufschnaiter

Sabrina Büttner

Verena Kohler

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2018-06-21T00:00:00Z

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P698

29977190

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P921

Parkinson's disease

P932

6021522

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