Directed evolution of an amine oxidase possessing both broad substrate specificity and high enantioselectivity
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Evolving P450pyr hydroxylase for highly enantioselective hydroxylation at non-activated carbon atomCombining a Clostridial enzyme exhibiting unusual active site plasticity with a remarkably facile sigmatropic rearrangement: rapid, stereocontrolled entry into densely functionalized fluorinated phosphonates for chemical biologyIPRO: an iterative computational protein library redesign and optimization procedureDirected evolution of D-sialic acid aldolase to L-3-deoxy-manno-2-octulosonic acid (L-KDO) aldolase.Stereoelectronic basis for the kinetic resolution of N-heterocycles with chiral acylating reagentsThe impact of enzyme engineering upon natural product glycodiversificationInversion of Extender Unit Selectivity in the Erythromycin Polyketide Synthase by Acyltransferase Domain Engineering.Controlling the enantioselectivity of enzymes by directed evolution: practical and theoretical ramifications.Recent developments in asymmetric multicomponent reactions.A Retrosynthesis Approach for Biocatalysis in Organic Synthesis.Amine dehydrogenases: efficient biocatalysts for the reductive amination of carbonyl compounds.Monoamine oxidase and transaminase screening: biotransformation of 2-methyl-6-alkylpiperidines by Neopestalotiopsis sp. CBMAI 2030Deracemization by simultaneous bio-oxidative kinetic resolution and stereoinversion.A regio- and stereoselective ω-transaminase/monoamine oxidase cascade for the synthesis of chiral 2,5-disubstituted pyrrolidines.Single-operation deracemization of 3H-indolines and tetrahydroquinolines enabled by phase separation.Understanding Flavin-Dependent Halogenase Reactivity via Substrate Activity Profiling.Asymmetric Preparation of prim-, sec-, and tert-Amines Employing Selected Biocatalysts.Directed evolution of an amine oxidase for the preparative deracemisation of cyclic secondary amines.Chemoenzymatic synthesis of all four diastereomers of 2,6-disubstituted piperidines through stereoselective monoamination of 1,5-diketones.Molecular determinants for substrate selectivity of ω-transaminases.Semi-rational Directed Evolution of Monoamine Oxidase for Kinetic Resolution of rac-Mexiletine.Enzymatic Ugi Reaction with Amines and Cyclic Imines.Biocatalytic oxidation reactions - a Chemist's perspective.Simultaneous engineering of an enzyme's entrance tunnel and active site: the case of monoamine oxidase MAO-NDiscovery and Protein Engineering of Biocatalysts for Organic SynthesisApplication of Enzymes in Kinetic Resolutions, Dynamic Kinetic Resolutions and Deracemization ReactionsBiocatalytic Approaches to the Synthesis of Enantiomerically Pure Chiral AminesDeracemisation of benzylisoquinoline alkaloids employing monoamine oxidase variantsMonoamine Oxidase-ω-Transaminase Cascade for the Deracemisation and Dealkylation of AminesDirected Evolution of the Enzyme Monoamine Oxidase (MAO-N): Highly Efficient Chemo-enzymatic Deracemisation of the Alkaloid (±)-Crispine AOxidation of CN BondsCytochromes P450 as useful biocatalysts: addressing the limitationsBiocatalytic Routes to Nonracemic Chiral Amines
P2860
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P2860
Directed evolution of an amine oxidase possessing both broad substrate specificity and high enantioselectivity
description
wetenschappelijk artikel
@nl
наукова стаття, опублікована в жовтні 2003
@uk
name
Directed evolution of an amine ...... ty and high enantioselectivity
@en
Directed evolution of an amine ...... ty and high enantioselectivity
@nl
type
label
Directed evolution of an amine ...... ty and high enantioselectivity
@en
Directed evolution of an amine ...... ty and high enantioselectivity
@nl
prefLabel
Directed evolution of an amine ...... ty and high enantioselectivity
@en
Directed evolution of an amine ...... ty and high enantioselectivity
@nl
P2093
P356
P1476
Directed evolution of an amine ...... ty and high enantioselectivity
@en
P2093
Alexis Enright
Marina Alexeeva
Reuben Carr
Tom S C Eve
P304
P356
10.1002/ANIE.200352100
P407
P577
2003-10-13T00:00:00Z