Exploiting plug-and-play synthetic biology for drug discovery and production in microorganisms
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Rational improvement of the engineered isobutanol-producing Bacillus subtilis by elementary mode analysisThe Sound of Silence: Activating Silent Biosynthetic Gene Clusters in Marine MicroorganismsMetabolomics methods for the synthetic biology of secondary metabolismMultiMetEval: comparative and multi-objective analysis of genome-scale metabolic modelsA novel muconic acid biosynthesis approach by shunting tryptophan biosynthesis via anthranilateDesign and development of synthetic microbial platform cells for bioenergyComputational approaches to natural product discoveryAtomic diffusion within individual gold nanocrystal.Coalition of Biology and Chemistry for Ameliorating Antimicrobial Drug Discovery.Recombinatorial biosynthesis of polyketides.Light-responsive control of bacterial gene expression: precise triggering of the lac promoter activity using photocaged IPTG.Principles of genetic circuit design.A tricistronic human adrenodoxin reductase-adrenodoxin-cytochrome P450 27A1 vector system for substrate hydroxylation in Escherichia coliDiversity and biotechnological potential of microorganisms associated with marine sponges.Regulation of the AbrA1/A2 two-component system in Streptomyces coelicolor and the potential of its deletion strain as a heterologous host for antibiotic production.A novel locus for mycelial aggregation forms a gateway to improved Streptomyces cell factoriesA systematic computational analysis of biosynthetic gene cluster evolution: lessons for engineering biosynthesisStrain-level diversity of secondary metabolism in Streptomyces albusCommentary: Toward a new focus in antibiotic and drug discovery from the Streptomyces arsenalRefactoring the nitrogen fixation gene cluster from Klebsiella oxytocaStructuring Microbial Metabolic Responses to Multiplexed Stimuli via Self-Organizing Metabolomics Maps.Metabolic Impacts of Using Nitrogen and Copper-Regulated Promoters to Regulate Gene Expression in Neurospora crassa.Synthetic Biology of Natural Products.Exploiting a precise design of universal synthetic modular regulatory elements to unlock the microbial natural products in Streptomyces.Multiplexed integrating plasmids for engineering of the erythromycin gene cluster for expression in Streptomyces spp. and combinatorial biosynthesis.Harnessing natural product assembly lines: structure, promiscuity, and engineering.Molecular regulation of antibiotic biosynthesis in streptomyces.Detecting sequence homology at the gene cluster level with MultiGeneBlast.Genetic circuit performance under conditions relevant for industrial bioreactors.Merging chemical ecology with bacterial genome mining for secondary metabolite discoveryEngineering antibiotic production and overcoming bacterial resistance.Exploring the metabolic state of microorganisms using metabolomics.Emerging biomedical applications of synthetic biology.Emerging tools for synthetic genome designTriggers and cues that activate antibiotic production by actinomycetes.Two-component systems in Streptomyces: key regulators of antibiotic complex pathways.Discovering new bioactive molecules from microbial sources.Synthetic biology advances for pharmaceutical production.Herboxidiene biosynthesis, production, and structural modifications: prospect for hybrids with related polyketide.Xantholipin B produced by the stnR inactivation mutant Streptomyces flocculus CGMCC 4.1223 WJN-1.
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Exploiting plug-and-play synthetic biology for drug discovery and production in microorganisms
description
article
@en
im Dezember 2010 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в грудні 2010
@uk
name
Exploiting plug-and-play synth ...... d production in microorganisms
@en
Exploiting plug-and-play synth ...... d production in microorganisms
@nl
type
label
Exploiting plug-and-play synth ...... d production in microorganisms
@en
Exploiting plug-and-play synth ...... d production in microorganisms
@nl
prefLabel
Exploiting plug-and-play synth ...... d production in microorganisms
@en
Exploiting plug-and-play synth ...... d production in microorganisms
@nl
P50
P356
P1476
Exploiting plug-and-play synth ...... d production in microorganisms
@en
P2093
Roel Bovenberg
P2888
P304
P356
10.1038/NRMICRO2478
P407
P577
2010-12-29T00:00:00Z