about
Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffoldsNesprin-2 is a multi-isomeric protein that binds lamin and emerin at the nuclear envelope and forms a subcellular network in skeletal muscleBidirectional cross-regulation between the endothelial nitric oxide synthase and β-catenin signalling pathwaysDistinct functional domains in nesprin-1alpha and nesprin-2beta bind directly to emerin and both interactions are disrupted in X-linked Emery-Dreifuss muscular dystrophyThe nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300Selumetinib, an Oral Anti-Neoplastic Drug, May Attenuate Cardiac Hypertrophy via Targeting the ERK PathwayNesprins: tissue-specific expression of epsilon and other short isoforms.Nesprin-2-dependent ERK1/2 compartmentalisation regulates the DNA damage response in vascular smooth muscle cell ageingSpecific localization of nesprin-1-α2, the short isoform of nesprin-1 with a KASH domain, in developing, fetal and regenerating muscle, using a new monoclonal antibody.Novel nuclear nesprin-2 variants tether active extracellular signal-regulated MAPK1 and MAPK2 at promyelocytic leukemia protein nuclear bodies and act to regulate smooth muscle cell proliferation.Nesprin-1/2: roles in nuclear envelope organisation, myogenesis and muscle disease.Nesprin-1 and actin contribute to nuclear and cytoskeletal defects in lamin A/C-deficient cardiomyopathy.Mutations at the lipoprotein lipase gene locus in subjects with diabetes mellitus, obesity and lipaemia.Paternal uniparental isodisomy of chromosome 6 causing a complex syndrome including complete IFN-gamma receptor 1 deficiencyApoA-IHelsinki (Lys107-->0) associated with reduced HDL cholesterol and LpA-I:A-II deficiencyOsteo/chondrocytic transcription factors and their target genes exhibit distinct patterns of expression in human arterial calcificationLipid transport genes and their relation to the syndrome of insulin resistanceMouse models of nesprin-related diseasesIdentification and Validation of Putative Nesprin VariantsNesprin-1-alpha2 associates with kinesin at myotube outer nuclear membranes, but is restricted to neuromuscular junction nuclei in adult muscle
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description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Qiuping Zhang
@ast
Qiuping Zhang
@en
Qiuping Zhang
@es
Qiuping Zhang
@nl
type
label
Qiuping Zhang
@ast
Qiuping Zhang
@en
Qiuping Zhang
@es
Qiuping Zhang
@nl
prefLabel
Qiuping Zhang
@ast
Qiuping Zhang
@en
Qiuping Zhang
@es
Qiuping Zhang
@nl
P106
P1153
36676129000
P31
P496
0000-0002-4000-3957