about
Crystal structure of the human prostacyclin synthaseCrystallographic analysis of the interaction of nitric oxide with quaternary-T human hemoglobinStructures of Prostacyclin Synthase and Its Complexes with Substrate Analog and Inhibitor Reveal a Ligand-specific Heme Conformation ChangeOn the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugsStructural characteristics of the nonallosteric human cytosolic malic enzymeCrystal structure of the S-nitroso form of liganded human hemoglobinXpsE oligomerization triggered by ATP binding, not hydrolysis, leads to its association with XpsLInvestigations into the binding of jadomycin DS to human topoisomerase IIβ by WaterLOGSY NMR spectroscopy.Functional characterization of the meiosis-specific DNA double-strand break inducing factor SPO-11 from C. elegans.Twisting of the DNA-binding surface by a beta-strand-bearing proline modulates DNA gyrase activity.Structural basis of the mercury(II)-mediated conformational switching of the dual-function transcriptional regulator MerRStructural basis of antizyme-mediated regulation of polyamine homeostasis.Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity.New insights into DNA-binding by type IIA topoisomerases.New mechanistic and functional insights into DNA topoisomerases.Chemical Inhibition of Human Thymidylate Kinase and Structural Insights into the Phosphate Binding Loop and Ligand-Induced Degradation.SMYD3-Mediated H2A.Z.1 Methylation Promotes Cell Cycle and Cancer Proliferation.Strong inhibition of betanodavirus replication by ribavirin targeting RNA-dependent RNA polymerase.In trans interaction of hepatitis C virus helicase domains mediates protease activity critical for internal NS3 cleavage and cell transformation.Asymmetrical synthesis of L-homophenylalanine using engineered Escherichia coli aspartate aminotransferase.Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry.Crystallization and preliminary X-ray crystallographic analysis of the C-terminal domain of ParC protein from Bacillus stearothermophilus.Insights into the Desaturation of Cyclopeptin and its C3 Epimer Catalyzed by a non-Heme Iron Enzyme: Structural Characterization and Mechanism Elucidation.Structural insights into the gating of DNA passage by the topoisomerase II DNA-gateMutation of a key residue in the type II secretion system ATPase uncouples ATP hydrolysis from protein translocationStructure and function of the XpsE N-terminal domain, an essential component of the Xanthomonas campestris type II secretion systemCys-93-betabeta-succinimidophenyl polyethylene glycol 2000 hemoglobin A. Intramolecular cross-bridging of hemoglobin outside the central cavityCrystal structure of the conserved hypothetical cytosolic protein Xcc0516 from Xanthomonas campestris reveals a novel quaternary structure assembled by five four-helix bundlesStructure of the topoisomerase IV C-terminal domain: a broken beta-propeller implies a role as geometry facilitator in catalysisAnthracenedione-methionine conjugates are novel topoisomerase II-targeting anticancer agents with favorable drug resistance profilesEpoxidation Catalyzed by the Nonheme Iron(II)- and 2-Oxoglutarate-Dependent Oxygenase, AsqJ: Mechanistic Elucidation of Oxygen Atom Transfer by a Ferryl Intermediate
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Nei-Li Chan
@ast
Nei-Li Chan
@en
Nei-Li Chan
@es
Nei-Li Chan
@nl
type
label
Nei-Li Chan
@ast
Nei-Li Chan
@en
Nei-Li Chan
@es
Nei-Li Chan
@nl
prefLabel
Nei-Li Chan
@ast
Nei-Li Chan
@en
Nei-Li Chan
@es
Nei-Li Chan
@nl
P106
P1153
7101677515
P31
P496
0000-0003-0139-6513