about
Molecular mechanism of action of microtubule-stabilizing anticancer agentsAntivascular and antitumor properties of the tubulin-binding chalcone TUB091Pironetin Binds Covalently to αCys316 and Perturbs a Major Loop and Helix of α-Tubulin to Inhibit Microtubule FormationA structure-based design of new C2- and C13-substituted taxanes: tubulin binding affinities and extended quantitative structure-activity relationships using comparative binding energy (COMBINE) analysis.New interfacial microtubule inhibitors of marine origin, PM050489/PM060184, with potent antitumor activity and a distinct mechanism.PM060184, a new tubulin binding agent with potent antitumor activity including P-glycoprotein over-expressing tumors.NMR determination of the bioactive conformation of peloruside A bound to microtubules.Insights into nucleotide recognition by cell division protein FtsZ from a mant-GTP competition assay and molecular dynamics.A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugsSynthesis and biological evaluation of colchicine C-ring analogues tethered with aliphatic linkers suitable for prodrug derivatisation.TRAPPII regulates exocytic Golgi exit by mediating nucleotide exchange on the Ypt31 ortholog RabERAB11.Cyclostreptin derivatives specifically target cellular tubulin and further map the paclitaxel site.Cytotoxic Activity and Chemical Composition of the Root Extract from the Mexican Species Linum scabrellum: Mechanism of Action of the Active Compound 6-Methoxypodophyllotoxin.The diamagnetic susceptibility of the tubulin dimer.Fluorescent taxoid probes for microtubule research.Triazolopyrimidines Are Microtubule-Stabilizing Agents that Bind the Vinca Inhibitor Site of Tubulin.Zampanolide, a Microtubule-Stabilizing Agent, Is Active in Resistant Cancer Cells and Inhibits Cell Migration.Quinolin-6-Yloxyacetamides Are Microtubule Destabilizing Agents That Bind to the Colchicine Site of Tubulin.Structural and Biochemical Characterization of the Interaction of Tubulin with Potent Natural Analogues of Podophyllotoxin.Synthesis and Anti-Proliferative Activity of Sulfanyltriazolylnaphthalenols and Sulfanyltriazolylnaphthalene-1,4-diones.Synthesis and biological evaluation of new oxadiazoline-substituted naphthalenyl acetates as anticancer agents.Structural Basis of Microtubule Stabilization by Discodermolide.Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.The impact of cyclopropane configuration on the biological activity of cyclopropyl-epothilones.Synthesis and biological evaluation of truncated α-tubulin-binding pironetin analogues lacking alkyl pendants in the side chain or the dihydropyrone ring.Endowing indole-based tubulin inhibitors with an anchor for derivatization: highly potent 3-substituted indolephenstatins and indoleisocombretastatins.Synthesis and biological evaluation as microtubule-active agents of several tetrahydrofuran and spiroacetal derivatives.Tubulin binding, protein-bound conformation in solution, and antimitotic cellular profiling of noscapine and its derivatives.Aggregated Compound Biological Signatures Facilitate Phenotypic Drug Discovery and Target Elucidation.Effects of C7 substitutions in a high affinity microtubule-binding taxane on antitumor activity and drug transport.Mechanism of action of the cytotoxic macrolides amphidinolide X and J.The binding mode of side chain- and C3-modified epothilones to tubulin.Optimization of taxane binding to microtubules: binding affinity dissection and incremental construction of a high-affinity analog of paclitaxel.Arylthioindole inhibitors of tubulin polymerization. 3. Biological evaluation, structure-activity relationships and molecular modeling studies.Overcoming tumor drug resistance with high-affinity taxanes: a SAR study of C2-modified 7-acyl-10-deacetyl cephalomannines.Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites.Free Energy Profile and Kinetics Studies of Paclitaxel Internalization from the Outer to the Inner Wall of Microtubules.Design, synthesis and biological evaluation of novel, simplified analogues of laulimalide: modification of the side chain.High affinity and covalent-binding microtubule stabilizing agents show activity in chemotherapy-resistant acute myeloid leukemia cells.Identification of pyrrolopyrimidine derivative PP-13 as a novel microtubule-destabilizing agent with promising anticancer properties
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description
researcher, ORCID id # 0000-0003-2743-3319
@en
wetenschapper
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name
J. Fernando Díaz
@ast
J. Fernando Díaz
@en
J. Fernando Díaz
@es
J. Fernando Díaz
@nl
type
label
J. Fernando Díaz
@ast
J. Fernando Díaz
@en
J. Fernando Díaz
@es
J. Fernando Díaz
@nl
prefLabel
J. Fernando Díaz
@ast
J. Fernando Díaz
@en
J. Fernando Díaz
@es
J. Fernando Díaz
@nl
P106
P1153
56244961600
P31
P496
0000-0003-2743-3319