about
Alternative modulation of protein-protein interactions by small moleculesSpecific inhibition of CK2α from an anchor outside the active siteComputationally-guided optimization of small-molecule inhibitors of the Aurora A kinase-TPX2 protein-protein interaction.Molecular characterization of latent GDF8 reveals mechanisms of activation.Structure of the human myostatin precursor and determinants of growth factor latency.Structural analyses of von Willebrand factor C domains of collagen 2A and CCN3 reveal an alternative mode of binding to bone morphogenetic protein-2.Development of a multipurpose scaffold for the display of peptide loops.Structural and Mechanistic Analysis of the Choline Sulfatase from Sinorhizobium melliloti: A Class I Sulfatase Specific for an Alkyl Sulfate Ester.Second-generation CK2α inhibitors targeting the αD pocket.Evolutionary repurposing of a sulfatase: A new Michaelis complex leads to efficient transition state charge offsetTwo-Component Stapling of Biologically Active and Conformationally Constrained Peptides: Past, Present, and FutureStructure of the human pro-myostatin precursor and determinants of growth factor latencyA general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody–drug conjugatesCorrection: A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody–drug conjugatesEfficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein-protein interaction.The thrombospondin module 1 domain of the matricellular protein CCN3 shows an atypical disulfide pattern and incomplete CWR layersWater-soluble, stable and azide-reactive strained dialkynes for biocompatible double strain-promoted click chemistryDiarylethene moiety as an enthalpy-entropy switch: photoisomerizable stapled peptides for modulating p53/MDM2 interaction
P50
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P50
description
researcher, ORCID id # 0000-0001-8683-4070
@en
wetenschapper
@nl
name
Marko Hyvönen
@ast
Marko Hyvönen
@en
Marko Hyvönen
@nl
type
label
Marko Hyvönen
@ast
Marko Hyvönen
@en
Marko Hyvönen
@nl
prefLabel
Marko Hyvönen
@ast
Marko Hyvönen
@en
Marko Hyvönen
@nl
P106
P31
P496
0000-0001-8683-4070