Shugoshin 1 is dislocated by KSHV-encoded LANA inducing aneuploidy

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Shugoshin 1 is dislocated by KSHV-encoded LANA inducing aneuploidy

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im September 2018 veröffentlichter wissenschaftlicher Artikel

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scientific article published on 13 September 2018

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wetenschappelijk artikel

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наукова стаття, опублікована у вересні 2018

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Shugoshin 1 is dislocated by KSHV-encoded LANA inducing aneuploidy

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Shugoshin 1 is dislocated by KSHV-encoded LANA inducing aneuploidy

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Shugoshin 1 is dislocated by KSHV-encoded LANA inducing aneuploidy

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Shugoshin 1 is dislocated by KSHV-encoded LANA inducing aneuploidy

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Shugoshin 1 is dislocated by KSHV-encoded LANA inducing aneuploidy

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Shugoshin 1 is dislocated by KSHV-encoded LANA inducing aneuploidy

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Shugoshin 1 is dislocated by KSHV-encoded LANA inducing aneuploidy

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Erle S Robertson

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Hem Chandra Jha

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Rajnish Kumar Singh

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Zhiguo Sun

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Human Bub1 defines the persistent cohesion site along the mitotic chromosome by affecting Shugoshin localization

Simian virus 40 large T antigen targets the spindle assembly checkpoint protein Bub1

Shugoshin collaborates with protein phosphatase 2A to protect cohesin

sSgo1, a major splice variant of Sgo1, functions in centriole cohesion where it is regulated by Plk1

Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint

PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation

Phospho-H2A and cohesin specify distinct tension-regulated Sgo1 pools at kinetochores and inner centromeres

Aneuploidy: cells losing their balance

Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis

Cell Cycle Regulatory Functions of the KSHV Oncoprotein LANA

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e1007253

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scholarly article

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10.1371/JOURNAL.PPAT.1007253

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English

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Fengchao Lang

Erle S Robertson

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2018-09-13T00:00:00Z

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30212568

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6136811

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