about
Inhibition of food intake in obese subjects by peptide YY3-36Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null miceCritical role for peptide YY in protein-mediated satiation and body-weight regulationRegulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, LnkDeletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic miceAMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons.Pharmacogenetic stimulation of cholinergic pedunculopontine neurons reverses motor deficits in a rat model of Parkinson's diseaseBio-informatics analysis of a gene co-expression module in adipose tissue containing the diet-responsive gene Nnat.Replication of extended lifespan phenotype in mice with deletion of insulin receptor substrate 1.Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands.Loss of AMP-activated protein kinase alpha2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia.Brain deletion of insulin receptor substrate 2 disrupts hippocampal synaptic plasticity and metaplasticity.Stat6 and IRS-2 cooperate in interleukin 4 (IL-4)-induced proliferation and differentiation but are dispensable for IL-4-dependent rescue from apoptosis.A link between FTO, ghrelin, and impaired brain food-cue responsivity.Mammalian models of extended healthy lifespan.Deletion of Lkb1 in pro-opiomelanocortin neurons impairs peripheral glucose homeostasis in miceDiet and gastrointestinal bypass-induced weight loss: the roles of ghrelin and peptide YY.Differential pre-mRNA splicing regulates Nnat isoforms in the hypothalamus after gastric bypass surgery in mice.Fibroblasts derived from long-lived insulin receptor substrate 1 null mice are not resistant to multiple forms of stress.Caloric restriction reveals a metabolomic and lipidomic signature in liver of male miceInsulin receptor substrate 2 is a negative regulator of memory formation.Metabotyping of long-lived mice using 1H NMR spectroscopyEvidence that hematopoietic stem cell function is preserved during aging in long-lived S6K1 mutant mice.Sex and death: what is the connection?mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype.Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production.Evolutionary conservation of regulated longevity assurance mechanismsLong-term p110α PI3K inactivation exerts a beneficial effect on metabolismLongevity of insulin receptor substrate1 null mice is not associated with increased basal antioxidant protection or reduced oxidative damage.Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell FunctionDeletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice.Peripheral activation of the Y2-receptor promotes secretion of GLP-1 and improves glucose tolerance.Differential effects of laparoscopic sleeve gastrectomy and laparoscopic gastric bypass on appetite, circulating acyl-ghrelin, peptide YY3-36 and active GLP-1 levels in non-diabetic humans.Visualizing Changes in Cdkn1c Expression Links Early-Life Adversity to Imprint Mis-regulation in Adults.Phosphoinositide signalling pathways in metabolic regulation.The hypoxia response pathway and β-cell function.Ribosomal S6K1 in POMC and AgRP Neurons Regulates Glucose Homeostasis but Not Feeding Behavior in MicePINK1 deficiency in β-cells increases basal insulin secretion and improves glucose tolerance in mice.LKB1 is required for hepatic bile acid transport and canalicular membrane integrity in mice.Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons.
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P50
description
researcher ORCID ID = 0000-0002-8009-7521
@en
name
Dominic J Withers
@ast
Dominic J Withers
@en
Dominic J Withers
@nl
type
label
Dominic J Withers
@ast
Dominic J Withers
@en
Dominic J Withers
@nl
prefLabel
Dominic J Withers
@ast
Dominic J Withers
@en
Dominic J Withers
@nl
P21
P31
P496
0000-0002-8009-7521