about
Alzheimer's disease: rare variants with large effect sizes.A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease.Parkinson disease polygenic risk score is associated with Parkinson disease status and age at onset but not with alpha-synuclein cerebrospinal fluid levels.Analysis of neurodegenerative Mendelian genes in clinically diagnosed Alzheimer Disease.Polygenic risk score of sporadic late-onset Alzheimer's disease reveals a shared architecture with the familial and early-onset forms.Assessment of the Genetic Architecture of Alzheimer's Disease Risk in Rate of Memory Decline.Evaluation of Gene-Based Family-Based Methods to Detect Novel Genes Associated With Familial Late Onset Alzheimer Disease.Genetic variants associated with Alzheimer's disease confer different cerebral cortex cell-type population structure.Genome-wide association study of brain amyloid deposition as measured by Pittsburgh Compound-B (PiB)-PET imagingGenome-wide association study for variants that modulate relationships between cerebrospinal fluid amyloid-beta 42, tau, and p-tau levelsIntegrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains reveal deficiencies of presynaptic signaling in FTLD and PSPTREM2 brain transcript-specific studies in AD and TREM2 mutation carriersSex-specific genetic predictors of Alzheimer's disease biomarkersA single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brainThe MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease riskThe TMEM106B FTLD-protective variant, rs1990621, is also associated with increased neuronal proportion
P50
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P50
description
investigador
@es
researcher
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wetenschapper
@nl
name
Jorge L Del-Aguila
@ast
Jorge L Del-Aguila
@en
Jorge L Del-Aguila
@es
Jorge L Del-Aguila
@nl
type
label
Jorge L Del-Aguila
@ast
Jorge L Del-Aguila
@en
Jorge L Del-Aguila
@es
Jorge L Del-Aguila
@nl
altLabel
Jorge Del-Aguila
@en
prefLabel
Jorge L Del-Aguila
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Jorge L Del-Aguila
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Jorge L Del-Aguila
@es
Jorge L Del-Aguila
@nl
P106
P1153
55337551900
P21
P2798
P31
P496
0000-0002-6364-8707