about
Insights into cytokine-receptor interactions from cytokine engineeringInstructive roles for cytokine-receptor binding parameters in determining signaling and functional potencyFunctional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO MutationReceptor dimer stabilization by hierarchical plasma membrane microcompartments regulates cytokine signaling.Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers.Multifarious determinants of cytokine receptor signaling specificity.Tuning cytokine receptor signaling by re-orienting dimer geometry with surrogate ligands.The IFN-λ-IFN-λR1-IL-10Rβ Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity.Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments.[Superkines: cytokines displaying better targeted functions].Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling.Mapping Determinants of Cytokine Signaling via Protein EngineeringKinetics of cytokine receptor trafficking determine signaling and functional selectivityMechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutationsLoss of adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22A strategy for the selection of monovalent antibodies that span protein dimer interfaces
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Q26852703-06F4E96C-BE5F-4270-BB08-BEFEE1A88A02Q27702599-274EB208-5510-4ECA-999E-7E3D18FACBA2Q29147543-BE957374-80C9-47D2-A442-F7BBCE905827Q30830679-584628AA-5026-4910-913A-180765414A3AQ36370053-DD6105EA-2AFB-40F0-B5D8-79859E6B6A74Q38175584-72E7056B-C3E0-4918-B2B3-42E569891162Q38625843-2CA00886-EECE-4D66-82CB-0C51D4AD3F9BQ40280003-F72CF886-019C-45B9-AD2E-D672F64D765FQ41077405-29C4B144-A6BE-4EF9-AD22-DAC3F77F88DBQ45892968-109B355B-A4D1-4D96-9A0A-CD662D1E5DE6Q50963822-00F94812-90D1-4065-B10A-BDAC93ED6985Q57490861-9AB4BD80-739A-4F55-9A92-70DF5FC95ABCQ83225765-A54310D7-57A2-4D9D-AA0D-FEF684DB5C50Q85544351-2AA78B3F-67C0-4F18-8F03-DF4F032C7C9CQ91464343-5CEAE6E0-158E-4C57-BD3B-99F537D49DEBQ92459952-EC7ECAC2-45FF-4CD9-B9D5-46D44671DCB1
P50
description
investigador
@es
researcher
@en
wetenschapper
@nl
name
Ignacio Moraga
@en
Ignacio Moraga
@nl
type
label
Ignacio Moraga
@en
Ignacio Moraga
@nl
prefLabel
Ignacio Moraga
@en
Ignacio Moraga
@nl
P31
P496
0000-0001-9909-0701