Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2 - Test2 - elhamkhani - TriplyDB

Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2

Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2

http://www.wikidata.org/entity/Q26269886

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Glucocerebrosidase is shaking up the synucleinopathies α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation Versatile Structures of α-Synuclein Alpha-synuclein Toxicity in the Early Secretory Pathway: How It Drives Neurodegeneration in Parkinsons Disease Biophysical characterization of α-synuclein and its controversial structure The Synaptic Function of α-Synuclein ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes APP is cleaved by Bace1 in pre-synaptic vesicles and establishes a pre-synaptic interactome, via its intracellular domain, with molecular complexes that regulate pre-synaptic vesicles functions Cholesterol in the Pathogenesis of Alzheimer's, Parkinson's Diseases and Autism: Link to Synaptic Dysfunction Tau association with synaptic vesicles causes presynaptic dysfunction.Blood RNA biomarkers in prodromal PARK4 and rapid eye movement sleep behavior disorder show role of complexin 1 loss for risk of Parkinson's disease.Nonaggregated α-synuclein influences SNARE-dependent vesicle docking via membrane binding.Synucleins regulate the kinetics of synaptic vesicle endocytosis.Complexin inhibits spontaneous release and synchronizes Ca2+-triggered synaptic vesicle fusion by distinct mechanisms Conformational heterogeneity of α-synuclein in membrane.Alpha-synuclein function and dysfunction on cellular membranes.Purification of α-synuclein from human brain reveals an instability of endogenous multimers as the protein approaches purity.Differential effects of dopamine signalling on long-term memory formation and consolidation in rodent brain.Munc18a does not alter fusion rates mediated by neuronal SNAREs, synaptotagmin, and complexin β-Amyloid and α-synuclein cooperate to block SNARE-dependent vesicle fusion Studying protein-reconstituted proteoliposome fusion with content indicators in vitro.Did α-Synuclein and Glucocerebrosidase Coevolve? Implications for Parkinson's Disease.Biophysics of α-synuclein induced membrane remodelling shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity.α-Synuclein expression in the mouse cerebellum is restricted to VGluT1 excitatory terminals and is enriched in unipolar brush cells.Lipid molecules influence early stages of yeast SNARE-mediated membrane fusion.N-terminal domain of complexin independently activates calcium-triggered fusion.Structural basis of synaptic vesicle assembly promoted by α-synuclein.Complexin-1 enhances the on-rate of vesicle docking via simultaneous SNARE and membrane interactions.C-terminal domain of mammalian complexin-1 localizes to highly curved membranes.Endosulfine-alpha inhibits membrane-induced α-synuclein aggregation and protects against α-synuclein neurotoxicity Evidence of native α-synuclein conformers in the human brain.Neurodegenerative Disease Related Proteins Have Negative Effects on SNARE-Mediated Membrane Fusion in Pathological Confirmation.The function of α-synuclein.A new pathway for mitochondrial quality control: mitochondrial-derived vesicles.The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans.Therapeutic strategies in Parkinson's disease: what we have learned from animal models.Structure, function and toxicity of alpha-synuclein: the Bermuda triangle in synucleinopathies.Review: Parkinson's disease: from synaptic loss to connectome dysfunction.Synaptic failure and α-synuclein.

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P2860

Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2

http://www.wikidata.org/entity/Q26269886

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Native α-synuclein induces clu ...... pids and synaptobrevin-2/VAMP2

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Daniel J Cipriano

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Manu Sharma

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Minjoung Kyoung

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Sandro Vivona

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P2860

Structure of membrane-bound alpha-synuclein from site-directed spin labeling and computational refinement

Site-specific interaction between α-synuclein and membranes probed by NMR-observed methionine oxidation rates

Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

Properties of native brain α-synuclein

Systematic mutagenesis of α-synuclein reveals distinct sequence requirements for physiological and pathological activities

Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions

Structures of segments of α-synuclein fused to maltose-binding protein suggest intermediate states during amyloid formation

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

Protein production by auto-induction in high density shaking cultures

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10.7554/ELIFE.00592

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Axel T. Brunger

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23638301

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