Inhibition of LRRK2 kinase activity stimulates macroautophagy
about
Deconvoluting the complexity of autophagy and Parkinson's disease for potential therapeutic purposeAutophagy and neurodegenerationThe role of the LRRK2 gene in ParkinsonismProgressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in miceDysregulation of autophagy and mitochondrial function in Parkinson's diseaseGenetics in Parkinson disease: Mendelian versus non-Mendelian inheritanceLRRK2 at the interface of autophagosomes, endosomes and lysosomesAutophagy in neurodegenerative diseases: from mechanism to therapeutic approachPathogenic Parkinson's disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvationLeucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brainmTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1ERKed by LRRK2: a cell biological perspective on hereditary and sporadic Parkinson's disease.Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy.The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling.LRRK2 and neuroinflammation: partners in crime in Parkinson's disease?LRRK2, a puzzling protein: insights into Parkinson's disease pathogenesisDefective autophagy in Parkinson's disease: lessons from genetics.Impaired mitochondrial homeostasis and neurodegeneration: towards new therapeutic targets?Cellular processes associated with LRRK2 function and dysfunctionLRRK2 Pathways Leading to Neurodegeneration.Genes associated with Parkinson's disease: regulation of autophagy and beyond.LRRK2 Kinase Inhibition as a Therapeutic Strategy for Parkinson's Disease, Where Do We Stand?LRRK2 at the Crossroad Between Autophagy and Microtubule Trafficking: Insights into Parkinson's Disease.Autophagy in the pathogenesis of ankylosing spondylitis.LRRK2 and Autophagy.Autophagy-from molecular mechanisms to clinical relevance.Prelysosomal Compartments in the Unconventional Secretion of Amyloidogenic Seeds.Sec16 in conventional and unconventional exocytosis: Working at the interface of membrane traffic and secretory autophagy?The LRRK2-macroautophagy axis and its relevance to Parkinson's diseaseUnderstanding the GTPase Activity of LRRK2: Regulation, Function, and Neurotoxicity.LRRK2 and the Immune System.The Role of Astrocyte Dysfunction in Parkinson's Disease Pathogenesis.Cross-cancer profiling of molecular alterations within the human autophagy interaction network.Fibroblast Biomarkers of Sporadic Parkinson's Disease and LRRK2 Kinase Inhibition.Computational analysis of the LRRK2 interactome.The G2019S LRRK2 mutation increases myeloid cell chemotactic responses and enhances LRRK2 binding to actin-regulatory proteins.Association of the LRRK2 genetic polymorphisms with leprosy in Han Chinese from Southwest China.Mitophagy in Parkinson's Disease: Pathogenic and Therapeutic Implications.The Upshot of LRRK2 Inhibition to Parkinson's Disease Paradigm.The LRRK2 signalling system.
P2860
Q26785491-BBD50857-E673-4685-B33A-63541FB127C0Q26991692-120762F9-4A2E-416A-8ECF-4D33B0C37F3AQ27023749-15FCE8E0-AAD2-4071-B5F4-09B46D864A80Q27308060-B60A7C9D-F0D7-4360-8587-245C7237231BQ28071890-66EB4CE0-EE6B-4787-836C-343D58D068E3Q28077356-6A185EA3-09F6-4A45-91B9-C172634B9198Q28078248-492DC2F4-83BB-4680-803D-BD190434717BQ28084605-E8F2EFA2-8940-4522-BAF5-8FB43AA35AB9Q28115231-AD408DE9-3190-49C3-A48F-1FC04DDFB27EQ28267434-0D65BF50-8349-46D6-9EDC-A69043A792C7Q28822211-4EE66FE3-BD08-4A2D-8051-FCD787E6C4B3Q33593798-C5406FDA-F33B-4EBF-8589-155AF5D92AFDQ33920691-9C160949-868D-48CF-81FE-BFB5769A4839Q35679501-AE234036-63C6-4493-9795-A1FC7E1A1AA9Q38198207-054ACE40-6B73-4B4D-972F-4E13F09E0FC1Q38218398-4F8D0075-B35B-4168-A01A-F66CC8DE21CAQ38225786-9D53B399-1F24-484E-BC3C-D73C8BBA9E03Q38248695-86AEB997-2072-449E-8899-98965DE7D187Q38433725-C9D5A07E-9197-4886-8AB8-74C8A665BD58Q38501861-1614742F-C031-47BB-8577-DC64632A36D6Q38557027-6A80FF18-DEAE-4803-9E0D-A1A1EC7862E5Q38620229-E8338921-667F-4690-A651-8E84865012A2Q38689010-2DE0E764-8E7F-4D32-AE45-B4150A13AF60Q38807627-4CFE542A-F878-47D0-BBC0-A8AE03DDA908Q38869514-2C65B4DA-08DA-4BA5-BD71-29876633E247Q39037205-6205129D-CC96-46F1-8727-A582B164FE3BQ39104462-F5CA5694-0AEB-42D8-961E-0A17A3F5FFACQ39119334-F9C5B2D3-88A0-48BE-979C-389E731E17BEQ39137355-FD408AE4-ACC4-4C3A-8251-EB595B16BE6FQ39206431-40265207-1AEC-41BE-8133-F2CAC83D4902Q39206438-A833AE57-5EF6-46B3-8DD6-191C47C85CD0Q39319763-16D5CFA7-6E47-422C-834E-9F036CA6950AQ40698951-468A83F2-6934-4ED4-86D9-576D593DF2A6Q41020334-81C683DC-C4B0-42A2-9216-87BDE4F249F1Q41301744-F28462EC-7BC7-45BE-B1F5-53F0C434BEF0Q41374126-D83F9A0A-F108-41F1-A731-DF2992CEAE04Q41592813-E4742809-933E-44F6-B6FB-AF3E4ED7079DQ42372932-EF7FDC32-9BA0-4597-AA2C-DC33C304F758Q46428440-DA9CF1E3-925D-4611-A735-4E748D0A3EE6Q47225650-B4342AC8-F179-4FB9-BB0C-E4F2C31E8BAE
P2860
Inhibition of LRRK2 kinase activity stimulates macroautophagy
description
2013 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2013
@ast
im Dezember 2013 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2013/12/01)
@sk
vědecký článek publikovaný v roce 2013
@cs
wetenschappelijk artikel (gepubliceerd op 2013/12/01)
@nl
наукова стаття, опублікована в грудні 2013
@uk
مقالة علمية (نشرت في ديسمبر 2013)
@ar
name
Inhibition of LRRK2 kinase activity stimulates macroautophagy
@ast
Inhibition of LRRK2 kinase activity stimulates macroautophagy
@en
Inhibition of LRRK2 kinase activity stimulates macroautophagy
@nl
type
label
Inhibition of LRRK2 kinase activity stimulates macroautophagy
@ast
Inhibition of LRRK2 kinase activity stimulates macroautophagy
@en
Inhibition of LRRK2 kinase activity stimulates macroautophagy
@nl
prefLabel
Inhibition of LRRK2 kinase activity stimulates macroautophagy
@ast
Inhibition of LRRK2 kinase activity stimulates macroautophagy
@en
Inhibition of LRRK2 kinase activity stimulates macroautophagy
@nl
P2093
P2860
P50
P3181
P1476
Inhibition of LRRK2 kinase activity stimulates macroautophagy
@en
P2093
Adamantios Mamais
Helene Plun-Favreau
Rina Bandopadhyay
Rosella Abeti
Sybille Dihanich
P2860
P304
P3181
P356
10.1016/J.BBAMCR.2013.07.020
P407
P577
2013-08-01T00:00:00Z