Pten is essential for embryonic development and tumour suppression
about
The lipid phosphatase activity of PTEN is critical for its tumor supressor functionOverexpression of kinase-associated phosphatase (KAP) in breast and prostate cancer and inhibition of the transformed phenotype by antisense KAP expressionInteraction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinaseEvidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2Phosphorylation of the PTEN tail regulates protein stability and functionPTEN expression is reduced in a subset of sporadic thyroid carcinomas: evidence that PTEN-growth suppressing activity in thyroid cancer cells mediated by p27kip1Negative regulation of G(1)/S transition by the candidate bladder tumour suppressor gene DBCCR1NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTENUbiquitination regulates PTEN nuclear import and tumor suppressionCancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein functionSOX9 elevation in the prostate promotes proliferation and cooperates with PTEN loss to drive tumor formationPhosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalitiesNuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent mannerPTEN function: how normal cells control it and tumour cells lose itPTEN represses RNA Polymerase I transcription by disrupting the SL1 complexActivation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damagePKN3 is required for malignant prostate cell growth downstream of activated PI 3-kinase.mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cellsBeclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressorProtein kinases and phosphatases in the control of cell fateProtean PTEN: form and functionTumor suppressors: enhancers or suppressors of regeneration?Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescenceThe tuberous sclerosis complexLymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytesA novel germline mutation of PTEN associated with brain tumours of multiple lineagesGenetic dissection of the miR-17~92 cluster of microRNAs in Myc-induced B-cell lymphomasmiR-19 is a key oncogenic component of mir-17-92Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathwaymTOR complex 2 is required for the development of prostate cancer induced by Pten loss in miceNKX3.1 expression is lost in testicular germ cell tumorsCritical role of PICT-1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic transformationPtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migrationTransgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cellsPten dose dictates cancer progression in the prostateDeficiency of Pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic miceLoss of cellular adhesion to matrix induces p53-independent expression of PTEN tumor suppressorPTEN deficiency: a role in mammary carcinogenesis.Mouse Models in Prostate Cancer Translational Research: From Xenograft to PDXClinical and Neurobiological Relevance of Current Animal Models of Autism Spectrum Disorders.
P2860
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P2860
Pten is essential for embryonic development and tumour suppression
description
1998 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
articolo scientifico
@it
artículu científicu espublizáu en 1998
@ast
im August 1998 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1998/08/01)
@sk
vědecký článek publikovaný v roce 1998
@cs
wetenschappelijk artikel (gepubliceerd op 1998/08/01)
@nl
наукова стаття, опублікована в серпні 1998
@uk
name
Pten is essential for embryonic development and tumour suppression
@ast
Pten is essential for embryonic development and tumour suppression
@en
Pten is essential for embryonic development and tumour suppression
@nl
type
label
Pten is essential for embryonic development and tumour suppression
@ast
Pten is essential for embryonic development and tumour suppression
@en
Pten is essential for embryonic development and tumour suppression
@nl
prefLabel
Pten is essential for embryonic development and tumour suppression
@ast
Pten is essential for embryonic development and tumour suppression
@en
Pten is essential for embryonic development and tumour suppression
@nl
P2093
P3181
P356
P1433
P1476
Pten is essential for embryonic development and tumour suppression
@en
P2093
C Cordon-Cardo
P P Pandolfi
P2888
P304
P3181
P356
10.1038/1235
P407
P577
1998-08-01T00:00:00Z