Diastolic dysfunction and altered energetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy
about
Micro-RNA-195 and -451 regulate the LKB1/AMPK signaling axis by targeting MO25Neonatal cardiomyopathy in mice homozygous for the Arg403Gln mutation in the alpha cardiac myosin heavy chain gene.Understanding cardiomyopathy phenotypes based on the functional impact of mutations in the myosin motorThe energetic cost of contraction is higher in the myocardium of patients with hypertrophic cardiomyopathyAltered cardiac excitation-contraction coupling in mutant mice with familial hypertrophic cardiomyopathyDifferential cross-bridge kinetics of FHC myosin mutations R403Q and R453C in heterozygous mouse myocardiumCardiac troponin T mutations result in allele-specific phenotypes in a mouse model for hypertrophic cardiomyopathyChanges in the chemical and dynamic properties of cardiac troponin T cause discrete cardiomyopathies in transgenic mice.Decreased energetics in murine hearts bearing the R92Q mutation in cardiac troponin TEchocardiographic strain imaging to assess early and late consequences of sarcomere mutations in hypertrophic cardiomyopathyProgressive loss of creatine maintains a near normal DeltaG approximately (ATP) in transgenic mouse hearts with cardiomyopathy caused by overexpressing Gsalpha.Exercise training improves age-related myocardial metabolic derangement: proton magnetic resonance spectroscopy study in the rat modelRescue of familial cardiomyopathies by modifications at the level of sarcomere and Ca2+ fluxes.What we know and do not know about sex and cardiac disease.The molecular genetic basis for hypertrophic cardiomyopathy.Molecular genetics and pathogenesis of hypertrophic cardiomyopathy.Hypertrophic cardiomyopathy: a heart in need of an energy bar?Somatic events modify hypertrophic cardiomyopathy pathology and link hypertrophy to arrhythmia.Reversibility of PRKAG2 glycogen-storage cardiomyopathy and electrophysiological manifestations.Heterogeneous myocyte enhancer factor-2 (Mef2) activation in myocytes predicts focal scarring in hypertrophic cardiomyopathy.The L-type calcium channel inhibitor diltiazem prevents cardiomyopathy in a mouse model.Molecular mechanisms of inherited cardiomyopathies.Cardiac troponin I Pro82Ser variant induces diastolic dysfunction, blunts β-adrenergic response, and impairs myofilament cooperativityGenetics and clinical destiny: improving care in hypertrophic cardiomyopathyManganese-enhanced MRI detection of impaired calcium regulation in a mouse model of cardiac hypertrophyPathogenesis of dilated cardiomyopathy: molecular, structural, and population analyses in tropomodulin-overexpressing transgenic mice.R-92L and R-92W mutations in cardiac troponin T lead to distinct energetic phenotypes in intact mouse hearts.Cell-intrinsic functional effects of the α-cardiac myosin Arg-403-Gln mutation in familial hypertrophic cardiomyopathy.Hypertrophic cardiomyopathy: translating cellular cross talk into therapeuticsADP-stimulated contraction: A predictor of thin-filament activation in cardiac disease.Magnetic resonance imaging and spectroscopy of the murine cardiovascular systemNormalization of cardiac substrate utilization and left ventricular hypertrophy precede functional recovery in heart failure regression.Liver Kinase B1 complex acts as a novel modifier of myofilament function and localizes to the Z-disk in cardiac myocytesEnergy metabolism in heart failure and remodelling.Creatine kinase adenosine triphosphate and phosphocreatine energy supply in a single kindred of patients with hypertrophic cardiomyopathySex dimorphisms of crossbridge cycling kinetics in transgenic hypertrophic cardiomyopathy miceRegulatory light chain mutations associated with cardiomyopathy affect myosin mechanics and kineticsIncreased myofilament Ca2+-sensitivity and arrhythmia susceptibility.Muscle dysfunction in hypertrophic cardiomyopathy: what is needed to move to translation?Mechanisms of disease: hypertrophic cardiomyopathy.
P2860
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P2860
Diastolic dysfunction and altered energetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy
description
1998 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1998
@ast
im April 1998 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1998/04/15)
@sk
vědecký článek publikovaný v roce 1998
@cs
wetenschappelijk artikel (gepubliceerd op 1998/04/15)
@nl
наукова стаття, опублікована у квітні 1998
@uk
مقالة علمية (نشرت في 15-4-1998)
@ar
name
Diastolic dysfunction and alte ...... al hypertrophic cardiomyopathy
@ast
Diastolic dysfunction and alte ...... al hypertrophic cardiomyopathy
@en
Diastolic dysfunction and alte ...... al hypertrophic cardiomyopathy
@nl
type
label
Diastolic dysfunction and alte ...... al hypertrophic cardiomyopathy
@ast
Diastolic dysfunction and alte ...... al hypertrophic cardiomyopathy
@en
Diastolic dysfunction and alte ...... al hypertrophic cardiomyopathy
@nl
prefLabel
Diastolic dysfunction and alte ...... al hypertrophic cardiomyopathy
@ast
Diastolic dysfunction and alte ...... al hypertrophic cardiomyopathy
@en
Diastolic dysfunction and alte ...... al hypertrophic cardiomyopathy
@nl
P2093
P2860
P356
P1476
Diastolic dysfunction and alte ...... al hypertrophic cardiomyopathy
@en
P2093
C. E. Seidman
H. L. Sweeney
J. G. Seidman
J. S. Ingwall
K. W. Saupe
M. E. Christe
M. Spindler
P2860
P304
P356
10.1172/JCI1940
P407
P577
1998-04-15T00:00:00Z