Diastolic dysfunction and altered energetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy - Test2 - elhamkhani - TriplyDB

Diastolic dysfunction and altered energetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy

Diastolic dysfunction and altered energetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy

http://www.wikidata.org/entity/Q28589243

about

Micro-RNA-195 and -451 regulate the LKB1/AMPK signaling axis by targeting MO25 Neonatal cardiomyopathy in mice homozygous for the Arg403Gln mutation in the alpha cardiac myosin heavy chain gene.Understanding cardiomyopathy phenotypes based on the functional impact of mutations in the myosin motor The energetic cost of contraction is higher in the myocardium of patients with hypertrophic cardiomyopathy Altered cardiac excitation-contraction coupling in mutant mice with familial hypertrophic cardiomyopathy Differential cross-bridge kinetics of FHC myosin mutations R403Q and R453C in heterozygous mouse myocardium Cardiac troponin T mutations result in allele-specific phenotypes in a mouse model for hypertrophic cardiomyopathy Changes in the chemical and dynamic properties of cardiac troponin T cause discrete cardiomyopathies in transgenic mice.Decreased energetics in murine hearts bearing the R92Q mutation in cardiac troponin T Echocardiographic strain imaging to assess early and late consequences of sarcomere mutations in hypertrophic cardiomyopathy Progressive loss of creatine maintains a near normal DeltaG approximately (ATP) in transgenic mouse hearts with cardiomyopathy caused by overexpressing Gsalpha.Exercise training improves age-related myocardial metabolic derangement: proton magnetic resonance spectroscopy study in the rat model Rescue of familial cardiomyopathies by modifications at the level of sarcomere and Ca2+ fluxes.What we know and do not know about sex and cardiac disease.The molecular genetic basis for hypertrophic cardiomyopathy.Molecular genetics and pathogenesis of hypertrophic cardiomyopathy.Hypertrophic cardiomyopathy: a heart in need of an energy bar?Somatic events modify hypertrophic cardiomyopathy pathology and link hypertrophy to arrhythmia.Reversibility of PRKAG2 glycogen-storage cardiomyopathy and electrophysiological manifestations.Heterogeneous myocyte enhancer factor-2 (Mef2) activation in myocytes predicts focal scarring in hypertrophic cardiomyopathy.The L-type calcium channel inhibitor diltiazem prevents cardiomyopathy in a mouse model.Molecular mechanisms of inherited cardiomyopathies.Cardiac troponin I Pro82Ser variant induces diastolic dysfunction, blunts β-adrenergic response, and impairs myofilament cooperativity Genetics and clinical destiny: improving care in hypertrophic cardiomyopathy Manganese-enhanced MRI detection of impaired calcium regulation in a mouse model of cardiac hypertrophy Pathogenesis of dilated cardiomyopathy: molecular, structural, and population analyses in tropomodulin-overexpressing transgenic mice.R-92L and R-92W mutations in cardiac troponin T lead to distinct energetic phenotypes in intact mouse hearts.Cell-intrinsic functional effects of the α-cardiac myosin Arg-403-Gln mutation in familial hypertrophic cardiomyopathy.Hypertrophic cardiomyopathy: translating cellular cross talk into therapeutics ADP-stimulated contraction: A predictor of thin-filament activation in cardiac disease.Magnetic resonance imaging and spectroscopy of the murine cardiovascular system Normalization of cardiac substrate utilization and left ventricular hypertrophy precede functional recovery in heart failure regression.Liver Kinase B1 complex acts as a novel modifier of myofilament function and localizes to the Z-disk in cardiac myocytes Energy metabolism in heart failure and remodelling.Creatine kinase adenosine triphosphate and phosphocreatine energy supply in a single kindred of patients with hypertrophic cardiomyopathy Sex dimorphisms of crossbridge cycling kinetics in transgenic hypertrophic cardiomyopathy mice Regulatory light chain mutations associated with cardiomyopathy affect myosin mechanics and kinetics Increased myofilament Ca2+-sensitivity and arrhythmia susceptibility.Muscle dysfunction in hypertrophic cardiomyopathy: what is needed to move to translation?Mechanisms of disease: hypertrophic cardiomyopathy.

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P2860

Diastolic dysfunction and altered energetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy

http://www.wikidata.org/entity/Q28589243

description

1998 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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1998 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

artículu científicu espublizáu en 1998

@ast

im April 1998 veröffentlichter wissenschaftlicher Artikel

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scientific journal article

@en

vedecký článok (publikovaný 1998/04/15)

@sk

vědecký článek publikovaný v roce 1998

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wetenschappelijk artikel (gepubliceerd op 1998/04/15)

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наукова стаття, опублікована у квітні 1998

@uk

مقالة علمية (نشرت في 15-4-1998)

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name

Diastolic dysfunction and alte ...... al hypertrophic cardiomyopathy

@ast

Diastolic dysfunction and alte ...... al hypertrophic cardiomyopathy

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Diastolic dysfunction and alte ...... al hypertrophic cardiomyopathy

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type

label

Diastolic dysfunction and alte ...... al hypertrophic cardiomyopathy

@ast

Diastolic dysfunction and alte ...... al hypertrophic cardiomyopathy

@en

Diastolic dysfunction and alte ...... al hypertrophic cardiomyopathy

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Diastolic dysfunction and alte ...... al hypertrophic cardiomyopathy

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Diastolic dysfunction and alte ...... al hypertrophic cardiomyopathy

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Diastolic dysfunction and alte ...... al hypertrophic cardiomyopathy

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Journal of Clinical Investigation

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Diastolic dysfunction and alte ...... al hypertrophic cardiomyopathy

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C. E. Seidman

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H. L. Sweeney

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J. G. Seidman

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J. S. Ingwall

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K. W. Saupe

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M. E. Christe

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M. Spindler

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P2860

Protein measurement with the Folin phenol reagent

Abnormal contractile properties of muscle fibers expressing beta-myosin heavy chain gene mutations in patients with hypertrophic cardiomyopathy

Cytosolic phosphorylation potential

A mouse model of familial hypertrophic cardiomyopathy

Electrophysiological abnormalities and arrhythmias in alpha MHC mutant familial hypertrophic cardiomyopathy mice

Genotype-phenotype correlations in hypertrophic cardiomyopathy. Insights provided by comparisons of kindreds with distinct and identical beta-myosin heavy chain gene mutations.

Compensatory mechanisms associated with the hyperdynamic function of phospholamban-deficient mouse hearts.

Role of MgADP in the development of diastolic dysfunction in the intact beating rat heart.

Effects of pH and free Mg2+ on the Keq of the creatine kinase reaction and other phosphate hydrolyses and phosphate transfer reactions.

The cytoplasmic phosphorylation potential. Its possible role in the control of myocardial respiration and cardiac contractility.

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10.1172/JCI1940

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8

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101

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9541509

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Myosin, heavy polypeptide 6, cardiac muscle, alpha

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508760

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