Hypertrophic and dilated cardiomyopathy mutations differentially affect the molecular force generation of mouse alpha-cardiac myosin in the laser trap assay.
about
Human actin mutations associated with hypertrophic and dilated cardiomyopathies demonstrate distinct thin filament regulatory properties in vitroUnderstanding cardiomyopathy phenotypes based on the functional impact of mutations in the myosin motorGenetics and disease of ventricular muscle.Genetic Variations Leading to Familial Dilated CardiomyopathyThe hypertrophic cardiomyopathy myosin mutation R453C alters ATP binding and hydrolysis of human cardiac β-myosinInsights into human beta-cardiac myosin function from single molecule and single cell studies.Echocardiographic strain imaging to assess early and late consequences of sarcomere mutations in hypertrophic cardiomyopathyMyosin transducer mutations differentially affect motor function, myofibril structure, and the performance of skeletal and cardiac musclesA mechanical model of actin stress fiber formation and substrate elasticity sensing in adherent cells.Harmonic force spectroscopy measures load-dependent kinetics of individual human β-cardiac myosin moleculesBiophysical properties of human β-cardiac myosin with converter mutations that cause hypertrophic cardiomyopathy.Heart failure switches the RV alpha1-adrenergic inotropic response from negative to positive.Rescue of familial cardiomyopathies by modifications at the level of sarcomere and Ca2+ fluxes.β-Myosin heavy chain variant Val606Met causes very mild hypertrophic cardiomyopathy in mice, but exacerbates HCM phenotypes in mice carrying other HCM mutationsCardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-β.The extent of cardiac myosin binding protein-C phosphorylation modulates actomyosin function in a graded mannerThe role of sarcomere gene mutations in patients with idiopathic dilated cardiomyopathy.Familial dilated cardiomyopathy caused by an alpha-tropomyosin mutation: the distinctive natural history of sarcomeric dilated cardiomyopathy.Narrative review: harnessing molecular genetics for the diagnosis and management of hypertrophic cardiomyopathy.Myocardial fibrosis as an early manifestation of hypertrophic cardiomyopathy.Kinetics of cardiac myosin isoforms in mouse myocardium are affected differently by presence of myosin binding protein-CIdentifying sarcomere gene mutations in hypertrophic cardiomyopathy: a personal historyTwo Drosophila myosin transducer mutants with distinct cardiomyopathies have divergent ADP and actin affinities.Therapeutic potential of c-Myc inhibition in the treatment of hypertrophic cardiomyopathy.Mechanistic heterogeneity in contractile properties of α-tropomyosin (TPM1) mutants associated with inherited cardiomyopathies.Expression of a Gi-coupled receptor in the heart causes impaired Ca2+ handling, myofilament injury, and dilated cardiomyopathyCell-intrinsic functional effects of the α-cardiac myosin Arg-403-Gln mutation in familial hypertrophic cardiomyopathy.Hypertrophic cardiomyopathy: translating cellular cross talk into therapeuticsMolecular mechanics of cardiac myosin-binding protein C in native thick filaments.Functional effects of the hypertrophic cardiomyopathy R403Q mutation are different in an alpha- or beta-myosin heavy chain backboneSubtle abnormalities in contractile function are an early manifestation of sarcomere mutations in dilated cardiomyopathy.Sex-related changes in cardiac function following myocardial infarction in mice.A Restrictive Cardiomyopathy Mutation in an Invariant Proline at the Myosin Head/Rod Junction Enhances Head Flexibility and Function, Yielding Muscle Defects in DrosophilaMolecular consequences of the R453C hypertrophic cardiomyopathy mutation on human β-cardiac myosin motor function.Integrative Analysis of PRKAG2 Cardiomyopathy iPS and Microtissue Models Identifies AMPK as a Regulator of Metabolism, Survival, and Fibrosis.Myosin-binding protein C displaces tropomyosin to activate cardiac thin filaments and governs their speed by an independent mechanism.Hypertrophic and dilated cardiomyopathy: four decades of basic research on muscle lead to potential therapeutic approaches to these devastating genetic diseases.A study of tropomyosin's role in cardiac function and disease using thin-filament reconstituted myocardium.The genetic basis of hypertrophic cardiomyopathy in cats and humans.Barth Syndrome: Connecting Cardiolipin to Cardiomyopathy.
P2860
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P2860
Hypertrophic and dilated cardiomyopathy mutations differentially affect the molecular force generation of mouse alpha-cardiac myosin in the laser trap assay.
description
2007 nî lūn-bûn
@nan
2007 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մարտին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Hypertrophic and dilated cardi ...... yosin in the laser trap assay.
@ast
Hypertrophic and dilated cardi ...... yosin in the laser trap assay.
@en
Hypertrophic and dilated cardi ...... yosin in the laser trap assay.
@nl
type
label
Hypertrophic and dilated cardi ...... yosin in the laser trap assay.
@ast
Hypertrophic and dilated cardi ...... yosin in the laser trap assay.
@en
Hypertrophic and dilated cardi ...... yosin in the laser trap assay.
@nl
prefLabel
Hypertrophic and dilated cardi ...... yosin in the laser trap assay.
@ast
Hypertrophic and dilated cardi ...... yosin in the laser trap assay.
@en
Hypertrophic and dilated cardi ...... yosin in the laser trap assay.
@nl
P2093
P2860
P1476
Hypertrophic and dilated cardi ...... yosin in the laser trap assay.
@en
P2093
D M Warshaw
Edward P Debold
J B Patlak
J G Seidman
J P Schmitt
P2860
P304
P356
10.1152/AJPHEART.00128.2007
P577
2007-03-09T00:00:00Z