Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2. - Test2 - elhamkhani - TriplyDB

Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2.

Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2.

http://www.wikidata.org/entity/Q34415806

about

Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death Targeted deletion of Hand2 in cardiac neural crest-derived cells influences cardiac gene expression and outflow tract development Atrioventricular cushion transformation is mediated by ALK2 in the developing mouse heart.Essential role of endothelial Notch1 in angiogenesis Hes1 expression is reduced in Tbx1 null cells and is required for the development of structures affected in 22q11 deletion syndrome HeyL regulates the number of TrkC neurons in dorsal root ganglia The Notch target genes Hey1 and Hey2 are required for embryonic vascular development Hey2 functions in parallel with Hes1 and Hes5 for mammalian auditory sensory organ development Transcription factor CHF1/Hey2 suppresses cardiac hypertrophy through an inhibitory interaction with GATA4 Transcription factor CHF1/Hey2 regulates coronary vascular maturation The bHLH transcription factor CHF1/Hey2 regulates susceptibility to apoptosis and heart failure after pressure overload.Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice Foxc transcription factors directly regulate Dll4 and Hey2 expression by interacting with the VEGF-Notch signaling pathways in endothelial cells.Sodium valproate-induced congenital cardiac abnormalities in mice are associated with the inhibition of histone deacetylase.Myocardial deletion of transcription factor CHF1/Hey2 results in altered myocyte action potential and mild conduction system expansion but does not alter conduction system function or promote spontaneous arrhythmias.Novel and functional DNA sequence variants within the GATA6 gene promoter in ventricular septal defects.Brugada syndrome risk loci seem protective against atrial fibrillation.The Notch pathway inhibits TGFβ signaling in breast cancer through HEYL-mediated crosstalk Developmental patterning of the cardiac atrioventricular canal by Notch and Hairy-related transcription factors An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation.The ciliary protein Ftm is required for ventricular wall and septal development.Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac function.Notch signaling plays a key role in cardiac cell differentiation.Differential role of Nkx2-5 in activation of the atrial natriuretic factor gene in the developing versus failing heart.Maternal and zygotic Zfp57 modulate NOTCH signaling in cardiac development.Vertebrate heart growth is regulated by functional antagonism between Gridlock and Gata5 Transcription factor CHF1/Hey2 regulates EC coupling and heart failure in mice through regulation of FKBP12.6.Generation of a conditional null allele of jumonji.The role of notch in modeling and maintaining the vasculature.Genetic modifiers predisposing to congenital heart disease in the sensitized Down syndrome population Superoxide Dismutase 1 In Vivo Ameliorates Maternal Diabetes Mellitus-Induced Apoptosis and Heart Defects Through Restoration of Impaired Wnt Signaling.Autoregulatory Control of Smooth Muscle Myosin Light Chain Kinase Promoter by Notch Signaling.Gene replacement strategies to test the functional redundancy of basic helix-loop-helix transcription factor.bHLH-Orange Transcription Factors in Development and Cancer.Cadherin-11 coordinates cellular migration and extracellular matrix remodeling during aortic valve maturation Delta-Notch--and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors Integration of TGF-beta/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition

P2860

Q24306881-005284F6-18C4-450A-955A-36746AC9EDE0 Q24337426-8B92F6A1-9A69-4787-867C-8EB02106CFF7 Q24645192-795FAF27-07B1-4453-AF5D-3909DE66228E Q28294931-8D4946D7-CD93-4B88-AEC7-813595FBEBF8 Q28506655-A70F43E5-D425-4534-B018-D1102907AFA0 Q28507415-626D8704-6175-497F-B416-DB6DC7C4970A Q28509482-B9272FED-2654-4578-8932-C364B823EA1F Q28513290-3D5B72EA-7136-4CA3-A9F8-3C51207FB83E Q28586531-7913055C-7963-4C2E-A763-8E0A06F317D7 Q28586854-CEDBF06C-22E4-413B-9D24-6A6E8CD6A092 Q28587058-929920AE-98CB-438A-90CB-9C9DCABAD002 Q28593631-237EF13C-4E80-456A-B9BB-9146607F734D Q28594504-2539DCF0-10F7-40E9-BFBF-4C0D669494A6 Q29347281-E8F59294-C663-4E76-B6DC-590739F7AA94 Q29619786-F109689D-DFF4-4409-80CC-25F46E6AB4F0 Q33342768-CC29CF41-75FE-4810-B7BB-4967229AE6B3 Q33736992-FA71885E-0744-476E-82E0-7DE3BA83B099 Q33775170-8B0A1438-39B2-42FA-985C-16AD910E6B4C Q34072482-632C0862-52C8-4B76-8FCE-8992B4B7829F Q34508291-74D92D56-B504-4317-A4BE-D1670B3E1A98 Q34518497-25D4ABBC-B7B6-4134-A834-C3122D6759EB Q34571556-D04EBCAE-979E-4B0E-ACD8-6DE157E2BF1B Q34608845-F02EFD89-EFD3-4FAC-8FC8-5F4275481A97 Q34612216-87D1D583-283F-493A-BA64-2EFA305877EF Q34623997-6912AC9F-F592-459A-829F-8A0160DA7A48 Q35033983-B530F3D1-1E53-4766-8898-205125FB75A6 Q35531101-D5282585-861A-45C0-96D4-5ACFA0C9CD6E Q35549396-59050213-2B4B-438E-935A-320370C098B2 Q35956783-197D5EB3-C83A-4FDE-A5D1-A3710ADF9C73 Q35993918-81EDB593-4B8E-4578-AD40-0116495C3851 Q36029854-6BD7F71A-EAB4-4BC2-9CD1-548D4DED4C65 Q36067007-8C936FEE-2EAF-46A4-9F4F-3BDD78D6C627 Q36068173-70B92965-763D-41B1-BA81-EBEE59D75D72 Q36199977-E48AADF3-ABC0-4E11-AF17-D0D3FC1D1190 Q36548425-19C533B2-893D-4D5D-8AF3-FF7A3AE08025 Q36635692-F987C7DE-0B9F-438C-83BA-058EC94E6480 Q36790868-E811AB89-DBC9-48DF-8168-39A31C6A3806 Q36826515-F257B2BE-283A-4401-A6B8-074C9925D87E Q36857288-025A7DFF-D7FB-45EB-9893-41E67F1F3043 Q37258903-503897B2-5DCA-45D3-9852-20F2264E2E52

P2860

Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2.

http://www.wikidata.org/entity/Q34415806

description

2002 nî lūn-bûn

@nan

2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2002年の論文

@ja

2002年論文

@yue

2002年論文

@zh-hant

2002年論文

@zh-hk

2002年論文

@zh-mo

2002年論文

@zh-tw

2002年论文

@wuu

name

Ventricular septal defect and ...... ranscription factor CHF1/Hey2.

@ast

Ventricular septal defect and ...... ranscription factor CHF1/Hey2.

@en

Ventricular septal defect and ...... ranscription factor CHF1/Hey2.

@nl

type

label

Ventricular septal defect and ...... ranscription factor CHF1/Hey2.

@ast

Ventricular septal defect and ...... ranscription factor CHF1/Hey2.

@en

Ventricular septal defect and ...... ranscription factor CHF1/Hey2.

@nl

prefLabel

Ventricular septal defect and ...... ranscription factor CHF1/Hey2.

@ast

Ventricular septal defect and ...... ranscription factor CHF1/Hey2.

@en

Ventricular septal defect and ...... ranscription factor CHF1/Hey2.

@nl

P1433

Q34415806-32B14C66-EDCD-4636-901B-97A710C9BABF

P1476

Q34415806-5624F9BE-4C90-4008-9E02-CDF89A23FFEC

P2093

Q34415806-0F239493-9FB1-4028-9F67-288DC2B2D291

Q34415806-1DBE8F5C-9966-42CD-8C1B-11C79000D384

Q34415806-2905290E-CFFD-4315-98E3-69C41FB3044E

Q34415806-6A8CEB8E-A310-4764-ADC4-0C5C33C649B3

Q34415806-EA32FE2D-33F4-4CEE-B13D-FF71E62D2E64

P2860

Q34415806-01099DF7-A6D6-457B-B1B9-97A6097E3EDE

Q34415806-1298DE8F-33C9-41F2-8B79-44E14B274D1E

Q34415806-1308B855-1A3D-4EFD-9932-39895FFE8EE9

Q34415806-199C6F19-9B90-4975-AE35-5A0976FFE759

Q34415806-19D9CC30-B0BC-4E39-8A7D-1A998253577F

Q34415806-22D498AF-CF0F-46B6-9E05-858A4C7FF8FF

Q34415806-2618BE56-492C-4546-9507-07256A76B4B3

Q34415806-272DF640-372D-4F77-80BE-6D28E1B59B34

Q34415806-2BD005C0-F0D7-41BC-BA4D-F2CE3B4BF4F3

Q34415806-37FE0799-6DCD-4F8A-A981-ED2CF663B606

P304

Q34415806-B51C2ECF-1042-4256-95C4-FE2244233ADC

P31

Q34415806-D70583C4-10C1-49AF-821C-2D69060E1A11

P356

Q34415806-31CFADC7-414F-45C3-ACFB-BE63304D049E

P407

Q34415806-B47C6BF1-B38C-4C38-9F8A-B557E739426A

P433

Q34415806-1F43A7EE-1DBF-47E5-AF7B-F313616CDFF8

P478

Q34415806-ED20354C-70BF-4385-82A3-F05DFE405A3D

P50

Q34415806-DDEE81B1-74D7-4AE4-A4EB-6475A802AF84

P577

Q34415806-6B158A62-0DA2-46A4-BCC9-E5C1149EF850

P5875

Q34415806-EE334D99-3A30-4AF6-9BC6-1AB58E80386D

P698

Q34415806-48A3DD52-D0A7-4577-B2AE-00BE7303E9C3

P932

Q34415806-8B86F7F5-0D57-4452-829B-31C6312DDC6C

P356

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Ventricular septal defect and ...... ranscription factor CHF1/Hey2.

@en

P2093

Caramai N Kamei

http://www.w3.org/2001/XMLSchema#string

James K Liao

http://www.w3.org/2001/XMLSchema#string

Michael T Chin

http://www.w3.org/2001/XMLSchema#string

Roderick Bronson

http://www.w3.org/2001/XMLSchema#string

Yasuhiko Sakata

http://www.w3.org/2001/XMLSchema#string

P2860

Neonatal cardiomyopathy in mice homozygous for the Arg403Gln mutation in the alpha cardiac myosin heavy chain gene.

Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways

Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system

HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling

Tetralogy of fallot and other congenital heart defects in Hey2 mutant mice

Congenital heart disease caused by mutations in the transcription factor NKX2-5

HERP, a new primary target of Notch regulated by ligand binding

Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling

gridlock, an HLH gene required for assembly of the aorta in zebrafish

Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family

P304

16197-16202

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.252648999

http://www.w3.org/2001/XMLSchema#string

P407

P433

25

http://www.w3.org/2001/XMLSchema#string

P478

99

http://www.w3.org/2001/XMLSchema#string

P50

Hironori Nakagami

P577

2002-11-26T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

11016038

http://www.w3.org/2001/XMLSchema#string

P698

12454287

http://www.w3.org/2001/XMLSchema#string

P932

138588

http://www.w3.org/2001/XMLSchema#string