urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPARFVIIIa variant:FIXa does not convert FX to the active FXakallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykininE-cadherin degradation by caspase-3 and calpain-1TYSND1 cleaves PHYHE-cadherin degradation by PS1:NCSTN (Gamma-secretase)Conversion of C2 into C2a and C2bFURIN Mediated SARS-CoV-2 Spike Protein Cleavage and EndocytosisFurin cleaves ANTXR2-bound pagA to yield pagA(197-794)Collagen type XVIII endostatin releaseCleavage of factor XII variant by activated thrombinCleavage of NODAL proproteinInitial activation of proMMP9 by MMPsCORIN(802-1042) hydrolyses NPPA to form NPPA(124-151)Cleavage of the signal peptide of PreproghrelinAutocatalytic activation of proMMP13FIX(29-461) variant is not activated (factor XIa catalyst)Activation of C1rC3(H2O):Factor Bb cleaves C3 to C3b and C3afactor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst)plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst)Autocatalytic activation of bound proMMP2plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst)Conversion of C4 into C4a and C4bFurin cleaves pro-BGLAP to BGLAPfactor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst)TYSND1 cleaves TYSND1MBTPS1 (S1P) cleaves CREB3L2HPN heterodimer cleaves pro-MST1 to form MST1 dimerMBTPS1 (S1P) cleaves CREB3L1Furin cleaves pro-prothrombin to prothrombinNID1 degradation by MMP1, 9, 12, ELANEfactor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst)Collagen type XVII ectodomain sheddingfactor V -> factor Va + factor V activation peptideCleavage of the viral Env gp160 precursor polyproteinfibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide BInitial activation of proMMP7 by trypsinActivation of proMMP8DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)
annotatedSource
definition
Catalysis of the hydrolysis of ...... c residue (usually histidine).
database_cross_reference
EC:3.4.19.1
EC:3.4.21.-
EC:3.4.21.1
EC:3.4.21.10
EC:3.4.21.102
EC:3.4.21.20
EC:3.4.21.21
EC:3.4.21.22
EC:3.4.21.26
EC:3.4.21.27
has_obo_namespace
molecular_function
has_related_synonym
blood coagulation factor activity
serine elastase activity
id
GO:0004252
in_subset
type
label
serine-type endopeptidase activity