guanyl-nucleotide exchange factor activity
Note that guanyl-nucleotide exchange factor (GEF) activity alters binding affinity, but not GTPase catalytic activity directly. Therefore GO:0005085 is under 'regulation of GTPase activity' but is not a 'GTPase regulator', which is reserved for cases where the action of one gene product directly alters the rate of catalysis by another gene product.
RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and METSOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants)Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange(Frs2)C3G stimulates nucleotide exchange on Rap1Guanine nucleotide exchange on RALGs activation by prostacyclin receptorNTRK2 activates RAS signaling through SHC1NTRK2 and CDK5 promote activation of RAC1 by TIAM1Activation of Cdc42 by pVav1RAB9 GEFs exchange GTP for GDP on RAB9RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFRFGFR3 fusions:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchangeActivated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchangeDENND6A,B exchange GTP for GDP on RAB14RIC1-RGP1 exchanges GTP for GDP on RAB6RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4RAB8 GEFs exchange GTP for GDP on RAB8Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchangeSOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptorsDENND5A,B exchange GTP for GDP on RAB39DENND1s exchange GTP for GDP on RAB35MADD exchanges GTP for GDP on RAB27Conversion of Ran-GDP to Ran-GTPRAB3 GEFs exchange GTP for GDP on RAB3ALiganded Gq/11-activating GPCRs act as GEFs for Gq/11WNT:FZD complex promotes G-protein nucleotide exchangeDOCK3 activates RAC1SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)Liganded Gz-activating GPCR acts as a GEF for GzRAB5 GEFs exchange GTP for GDP on RAB5RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimersNucleotide exchange on RAB1MON1:CCZ1 exchanges GTP for GDP on RAB7RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutantsMuscarinic Acetylcholine Receptor M3 activates Gqtrans-Golgi Network Coat ActivationKALRN exchanges GTP for GDP on RAC1, activating itActivation of Rap1 by membrane-associated GEFsDOCK7 activates RAC1Regeneration of eEF1A:GTP by eEF1B activity
annotatedSource
guanyl-nucleotide exchange factor activity
Note that guanyl-nucleotide exchange factor (GEF) activity alters binding affinity, but not GTPase catalytic activity directly. Therefore GO:0005085 is under 'regulation of GTPase activity' but is not a 'GTPase regulator', which is reserved for cases where the action of one gene product directly alters the rate of catalysis by another gene product.
definition
Stimulates the exchange of gua ...... n association with the GTPase.
term tracker item
has_alternative_id
GO:0005086
GO:0005087
GO:0005088
GO:0005089
GO:0005090
GO:0008321
GO:0008433
GO:0016219
GO:0016220
GO:0017034
database_cross_reference
Reactome:R-HSA-109807
Reactome:R-HSA-109817
Reactome:R-HSA-114544
Reactome:R-HSA-1168636
Reactome:R-HSA-1225951
Reactome:R-HSA-1225957
Reactome:R-HSA-1250383
Reactome:R-HSA-1250463
Reactome:R-HSA-1250498
Reactome:R-HSA-1306972
has_exact_synonym
GDP-dissociation stimulator activity
Rho guanine nucleotide exchange factor
guanyl-nucleotide release factor activity
guanyl-nucleotide releasing factor
has_narrow_synonym
ARF guanyl-nucleotide exchange factor activity
Rab guanyl-nucleotide exchange factor activity
Rac guanyl-nucleotide exchange factor activity
Ral guanyl-nucleotide exchange factor activity
Ran guanyl-nucleotide exchange factor activity
Rap guanyl-nucleotide exchange factor activity
Ras guanyl-nucleotide exchange factor activity
Rho guanyl-nucleotide exchange factor activity
Sar guanyl-nucleotide exchange factor activity
has_obo_namespace
molecular_function
id
GO:0005085
type
comment
Note that guanyl-nucleotide ex ...... lysis by another gene product.
label
guanyl-nucleotide exchange factor activity