Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation
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PINK1 is selectively stabilized on impaired mitochondria to activate ParkinGenetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation updateFunctional alteration of PARL contributes to mitochondrial dysregulation in Parkinson's diseaseDJ-1 interacts with RACK1 and protects neurons from oxidative-stress-induced apoptosisLoss of Mel-18 induces tumor angiogenesis through enhancing the activity and expression of HIF-1α mediated by the PTEN/PI3K/Akt pathwayPhosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1)-dependent ubiquitination of endogenous Parkin attenuates mitophagy: study in human primary fibroblasts and induced pluripotent stem cell-derived neuronsPhosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signalingBAG5 protects against mitochondrial oxidative damage through regulating PINK1 degradationLoss of PINK1 attenuates HIF-1α induction by preventing 4E-BP1-dependent switch in protein translation under hypoxiaStructure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of NeuroprotectionMitochondrial dysfunction in ataxia-telangiectasiaThe ubiquitin proteasome system in neuropathologyMitochondrial Dysfunction in Cancer and Neurodegenerative Diseases: Spotlight on Fatty Acid Oxidation and Lipoperoxidation ProductsMitochondria: A Therapeutic Target for Parkinson's Disease?Mitochondrial targets for pharmacological intervention in human diseaseRBR E3 ubiquitin ligases: new structures, new insights, new questionsMouse models of Parkinson's disease associated with mitochondrial dysfunctionGenetics of Parkinson's disease - a clinical perspectiveMitochondria and mitophagy: the yin and yang of cell death control60th residues of ubiquitin and Nedd8 are located out of E2-binding surfaces, but are important for K48 ubiquitin-linkageStructure of the human Parkin ligase domain in an autoinhibited stateDysregulation of Ubiquitin-Proteasome System in Neurodegenerative DiseasesSerotonin 1A Receptors on Astrocytes as a Potential Target for the Treatment of Parkinson's DiseaseMolecular chaperone-mediated rescue of mitophagy by a Parkin RING1 domain mutantEvidence for a common biological pathway linking three Parkinson's disease-causing genes: parkin, PINK1 and DJ-1Gene-environment interactions: key to unraveling the mystery of Parkinson's diseaseBeyond mitophagy: cytosolic PINK1 as a messenger of mitochondrial healthModularity in protein complex and drug interactions reveals new polypharmacological propertiesPINK1-dependent recruitment of Parkin to mitochondria in mitophagy.PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65Regulation of parkin and PINK1 by neddylation.Pathway-specific dopaminergic deficits in a mouse model of Angelman syndromeA neo-substrate that amplifies catalytic activity of parkinson's-disease-related kinase PINK1.Evidence for gender-specific transcriptional profiles of nigral dopamine neurons in Parkinson diseaseMitochondrial quality control: insights on how Parkinson's disease related genes PINK1, parkin, and Omi/HtrA2 interact to maintain mitochondrial homeostasis.Structural determinants of PINK1 topology and dual subcellular distributionDJ-1 deficient mice demonstrate similar vulnerability to pathogenic Ala53Thr human alpha-syn toxicity.A pivotal role for PINK1 and autophagy in mitochondrial quality control: implications for Parkinson disease.Reactive oxygen species-mediated DJ-1 monomerization modulates intracellular trafficking involving karyopherin β2Parkin in the regulation of fat uptake and mitochondrial biology: emerging links in the pathophysiology of Parkinson's disease.
P2860
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P248
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P2860
Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation
description
2009 nî lūn-bûn
@nan
2009 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մարտին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Parkin, PINK1, and DJ-1 form a ...... g unfolded protein degradation
@ast
Parkin, PINK1, and DJ-1 form a ...... g unfolded protein degradation
@en
Parkin, PINK1, and DJ-1 form a ...... g unfolded protein degradation
@en-gb
Parkin, PINK1, and DJ-1 form a ...... g unfolded protein degradation
@nl
type
label
Parkin, PINK1, and DJ-1 form a ...... g unfolded protein degradation
@ast
Parkin, PINK1, and DJ-1 form a ...... g unfolded protein degradation
@en
Parkin, PINK1, and DJ-1 form a ...... g unfolded protein degradation
@en-gb
Parkin, PINK1, and DJ-1 form a ...... g unfolded protein degradation
@nl
prefLabel
Parkin, PINK1, and DJ-1 form a ...... g unfolded protein degradation
@ast
Parkin, PINK1, and DJ-1 form a ...... g unfolded protein degradation
@en
Parkin, PINK1, and DJ-1 form a ...... g unfolded protein degradation
@en-gb
Parkin, PINK1, and DJ-1 form a ...... g unfolded protein degradation
@nl
P2093
P2860
P3181
P356
P1476
Parkin, PINK1, and DJ-1 form a ...... g unfolded protein degradation
@en
P2093
Chengyuan Tang
Danling Wang
Linan Chen
Xiaoxi Zhuang
Yeun Su Choo
Zhuohua Zhang
P2860
P304
P3181
P356
10.1172/JCI37617
P407
P50
P577
2009-03-01T00:00:00Z