Leucine 255 of Src couples intramolecular interactions to inhibition of catalysis.
about
Trafficking of Lyn through the Golgi caveolin involves the charged residues on alphaE and alphaI helices in the kinase domainc-Src-mediated phosphorylation of hnRNP K drives translational activation of specifically silenced mRNAsActive site profiling reveals coupling between domains in SRC-family kinasesConserved hydrophobicity in the SH2-kinase linker is required for catalytic activity of Csk and CHKThe SH2 domain regulates c-Abl kinase activation by a cyclin-like mechanism and remodulation of the hinge motionThe Activation of c-Src Tyrosine Kinase: Conformational Transition Pathway and Free Energy Landscape.SH2-catalytic domain linker heterogeneity influences allosteric coupling across the SFK family.An electrostatic network and long-range regulation of Src kinasesConformational basis for SH2-Tyr(P)527 binding in Src inactivation.An examination of dynamics crosstalk between SH2 and SH3 domains by hydrogen/deuterium exchange and mass spectrometry.An intramolecular interaction between SH2-kinase linker and kinase domain is essential for the catalytic activity of protein-tyrosine kinase-6.Structure and regulation of Src family kinases.Conformation of full-length Bruton tyrosine kinase (Btk) from synchrotron X-ray solution scattering.The distinct capacity of Fyn and Lck to phosphorylate Sam68 in T cells is essentially governed by SH3/SH2-catalytic domain linker interactions.Molecular rulers: an assessment of distance and spatial relationships of Src tyrosine kinase Sh2 and active site regions.JAK2 V617F constitutive activation requires JH2 residue F595: a pseudokinase domain target for specific inhibitorsCellulase linkers are optimized based on domain type and function: insights from sequence analysis, biophysical measurements, and molecular simulation.Construction of a linker library with widely controllable flexibility for fusion protein design.Computational study of the W260A activating mutant of Src tyrosine kinase.Mutational analysis of the SH2-kinase linker region of Bruton's tyrosine kinase defines alternative modes of regulation for cytoplasmic tyrosine kinase families.HLJ1 is an endogenous Src inhibitor suppressing cancer progression through dual mechanisms.AC-93253 iodide, a novel Src inhibitor, suppresses NSCLC progression by modulating multiple Src-related signaling pathways.A switch in nucleotide affinity governs activation of the Src and Tec family kinases.
P2860
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P2860
Leucine 255 of Src couples intramolecular interactions to inhibition of catalysis.
description
1999 nî lūn-bûn
@nan
1999 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Leucine 255 of Src couples intramolecular interactions to inhibition of catalysis.
@ast
Leucine 255 of Src couples intramolecular interactions to inhibition of catalysis.
@en
type
label
Leucine 255 of Src couples intramolecular interactions to inhibition of catalysis.
@ast
Leucine 255 of Src couples intramolecular interactions to inhibition of catalysis.
@en
prefLabel
Leucine 255 of Src couples intramolecular interactions to inhibition of catalysis.
@ast
Leucine 255 of Src couples intramolecular interactions to inhibition of catalysis.
@en
P2093
P356
P1476
Leucine 255 of Src couples intramolecular interactions to inhibition of catalysis.
@en
P2093
P2888
P304
P356
10.1038/11537
P577
1999-08-01T00:00:00Z
P5875
P6179
1010980310