about
P688
CNNM2, encoding a basolateral protein required for renal Mg2+ handling, is mutated in dominant hypomagnesemiaUromodulin is expressed in renal primary cilia and UMOD mutations result in decreased ciliary uromodulin expressionRenal effects of Tamm-Horsfall protein (uromodulin) deficiency in miceTamm-Horsfall protein is a critical renal defense factor protecting against calcium oxalate crystal formationScreening for increased plasma urea levels in a large-scale ENU mouse mutagenesis project reveals kidney disease modelsUse of dual section mRNA in situ hybridisation/immunohistochemistry to clarify gene expression patterns during the early stages of nephron development in the embryo and in the mature nephron of the adult mouse kidneyTamm-Horsfall glycoprotein interacts with renal outer medullary potassium channel ROMK2 and regulates its functionProgressive renal papillary calcification and ureteral stone formation in mice deficient for Tamm-Horsfall proteinThe lectin-like interaction between recombinant tumor necrosis factor and uromodulin.Activation of the bumetanide-sensitive Na+,K+,2Cl- cotransporter (NKCC2) is facilitated by Tamm-Horsfall protein in a chloride-sensitive mannerUrinary secretion and extracellular aggregation of mutant uromodulin isoforms.Early involvement of cellular stress and inflammatory signals in the pathogenesis of tubulointerstitial kidney disease due to UMOD mutations.Tamm-Horsfall protein knockout mice are more prone to urinary tract infection: rapid communication.Point mutation in D8C domain of Tamm-Horsfall protein/uromodulin in transgenic mice causes progressive renal damage and hyperuricemia.Renal calcinosis and stone formation in mice lacking osteopontin, Tamm-Horsfall protein, or both.Uromodulin p.Cys147Trp mutation drives kidney disease by activating ER stress and apoptosis.Ablation of the Tamm-Horsfall protein gene increases susceptibility of mice to bladder colonization by type 1-fimbriated Escherichia coli.Uromodulin is expressed in the distal convoluted tubule, where it is critical for regulation of the sodium chloride cotransporter NCC
P921
Q24296446-9537105B-3032-4506-889E-736BB90D771FQ24300384-92AB5634-B8FC-428B-BD84-BF7A4B4B7E1BQ28291423-EF3494CD-CA4E-485C-B91C-BB4692B3C6B7Q28504800-E2F1AAE1-34B2-42BF-87C8-1AA39552C8BEQ28505175-9E148EC7-81D0-43A9-BA0A-875920CF7E98Q28505986-66293C0F-AEEA-467C-A9AF-2D541082FEAAQ33748345-7231EB2D-4C54-4723-A0A8-834BA06FE8FEQ34149642-3109B0C5-27E7-4E2F-BAB3-FD09A05AEBDBQ38347456-E9CBC3BC-5792-4428-99EA-28A1F279F2C6Q38676686-B84187F9-AD24-4B1A-8E32-9D5A7A404A84Q39413596-0FAF562B-27B0-4472-B158-E62034BEB00CQ41287767-16BB9A53-11C6-498C-9DA9-92E849958E3CQ44376514-449C3A6F-A220-4C66-8E50-57B1BE83141CQ46823378-E7EAB1D5-37D2-4264-AA08-AE018A7AB1D5Q46980085-09981C3C-A28C-4561-B76A-3E5FF45EC6ADQ47678474-40439CD6-B7E1-40CE-B33F-E0E3ABAB639BQ54514177-6AC79286-EB76-423C-A338-59B7EAE69155Q90211500-5CDF7AB6-6977-4FAD-86E2-F430AB555EE3
P921
description
mammalian protein found in Mus musculus
@en
protein
@id
protein
@sv
proteinë
@sq
proteïne in Uromodulin
@nl
protèin
@ace
protéine
@fr
بروتين في فأر المنازل
@ar
name
Uromodulin
@en
type
label
Uromodulin
@en
altLabel
THP
@en
Tamm-Horsfall urinary glycoprotein
@en
Umod
@en
uromodulin
@en
uromucoid
@en
prefLabel
Uromodulin
@en
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ENSMUSP00000033263
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ENSMUSP00000146652
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ENSMUSP00000147128