about
P688
Functional alteration of PARL contributes to mitochondrial dysregulation in Parkinson's diseasePINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motilityPARK13 regulates PINK1 and subcellular relocation patterns under oxidative stress in neuronsThe mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 traffickingBRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potentialMutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stabilityIncrease of oxidative stress by a novel PINK1 mutation, P209ABiochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysisPINK1 kinase catalytic activity is regulated by phosphorylation on serines 228 and 402PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1PINK1 cleavage at position A103 by the mitochondrial protease PARL.A new cytosolic pathway from a Parkinson disease-associated kinase, BRPK/PINK1: activation of AKT via mTORC2Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's diseaseLoss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fissionThe kinase domain of mitochondrial PINK1 faces the cytoplasmPINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neuronsBAG5 protects against mitochondrial oxidative damage through regulating PINK1 degradationOxidative stress-induced signaling pathways implicated in the pathogenesis of Parkinson's diseaseHereditary early-onset Parkinson's disease caused by mutations in PINK1PINK1 protein in normal human brain and Parkinson's diseaseLoss of PINK1 attenuates HIF-1α induction by preventing 4E-BP1-dependent switch in protein translation under hypoxiaPharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease.Mitochondrial impairment increases FL-PINK1 levels by calcium-dependent gene expressionMitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitmentRewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis
P921
Q50269773-808E6259-B3DE-4297-9E71-89EE17C50C78Q50296954-79E63E41-C994-492D-B816-9E5BD47D44FFQ50296954-B2B411D8-D561-48A3-B4F3-7800D2CB58F8Q50296955-8887E4DE-8FE0-4D3A-B4AC-D20AF370A471Q50296955-E20247A8-CBFC-4D40-9D10-EBBF17EA2B07Q50296956-2990C211-459D-42F9-B56A-F698EFBF9671Q50296956-648984AC-9966-41E5-880E-3029E8CF26BDQ50296957-FE324B87-BC57-4E21-898F-A798D8FF13D0
P527
Q24294218-795A4C53-65D3-4F44-8B49-FF943CCABBC9Q24296955-EE2AC75A-1F3E-4A9D-9FAB-AD577F462324Q24297072-68162BFD-9C88-4D52-A29A-8C992A389DA1Q24297960-9DB62ACC-F11D-4DB9-A4C9-5365ED2244DAQ24299356-FDDCDEA9-73EA-4FBD-9FD3-D66435ECF386Q24299939-13685BF9-A68C-4034-8A5D-25400C6CD20DQ24306774-65BC8A65-6BDA-4EEA-9A29-E508004B8F51Q24307730-40A9E04E-8D06-4AFF-BAEE-7DCFD60F7655Q24310659-D8DE3588-5B10-477A-AF2B-1FCC1D93CD2DQ24310717-E39E7A2A-E52E-4D6F-BC26-62B0CC82C6C9Q24312106-86A39959-0DEC-4BB1-A67B-BB058ECD3D93Q24313472-881FB27B-5AA1-4128-87CE-306577CE5D4AQ24319028-ED03B48D-4506-499F-9AD9-6F9BBA5A1DD3Q24319830-4CAAF0AE-1805-4050-828A-AAA03546EE2EQ24320327-724C7F95-3709-46FE-B4F9-2E794BFA6850Q24321709-DA2C351D-7CB9-4CA5-A9F1-C484E8657A30Q24322788-2B1A2DAA-A4F3-4AD5-BCD1-F48577D59586Q24324175-7A6B7E0D-98B9-480A-8F02-D28D4C9C893BQ24337079-E7AEF85F-7DB1-4BCA-B65F-0223378F4EB8Q24337084-28C3C2B2-7459-44E8-8FE4-BABAE851455EQ24337151-881CE6D7-F62D-49EE-A154-A994B82DEB5BQ24337840-25614BBA-1C71-4878-B9E4-503FD8769447Q24339508-C26803D7-5261-4D5E-8752-ACAC0F2DBA9EQ28115890-D6A25147-466D-4429-ADA0-AE4769337311Q35874914-2FCF25E0-2BE3-4857-841E-A208CC90CDA7Q90180281-38FDE560-A033-4B7E-98D0-33C8280968DA
P921
description
Protein in Homo sapiens
@de
mammalian protein found in Homo sapiens
@en
protein
@id
protein
@sv
proteinë
@sq
proteïne in PTEN induced kinase 1
@nl
protèin
@ace
بروتين في الإنسان العاقل
@ar
name
PTEN induced kinase 1
@en
PTEN induced kinase 1
@nl
type
label
PTEN induced kinase 1
@en
PTEN induced kinase 1
@nl
altLabel
BRPK
@en
PINK1
@en
PTEN induced putative kinase 1
@en
PTEN-induced putative kinase protein 1
@en
protein kinase BRPK
@en
serine/threonine-protein kinase PINK1, mitochondrial
@en
prefLabel
PTEN induced kinase 1
@en
PTEN induced kinase 1
@nl
P680
P681
P682
P352
P637
P31
P352
P637
P680
P681
P682
P702
P703
P705
ENSP00000364204