Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions - Wikidata - wikimedia - TriplyDB

Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions

Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions

http://www.wikidata.org/entity/Q22009563

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Relationships between the sequence of alpha-synuclein and its membrane affinity, fibrillization propensity, and yeast toxicity Synphilin-1 is developmentally localized to synaptic terminals, and its association with synaptic vesicles is modulated by alpha-synuclein Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration.Protein phosphatase 1α interacting proteins in the human brain LRRK2 interactions with α-synuclein in Parkinson's disease brains and in cell models The Guanine nucleotide exchange factor kalirin-7 is a novel synphilin-1 interacting protein and modifies synphilin-1 aggregate transport and formation Parkin accumulation in aggresomes due to proteasome impairment Synphilin-1A: an aggregation-prone isoform of synphilin-1 that causes neuronal death and is present in aggregates from alpha-synucleinopathy patients Multiple system atrophy: cellular and molecular pathology.How does parkin ligate ubiquitin to Parkinson's disease?Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth NUB1 suppresses the formation of Lewy body-like inclusions by proteasomal degradation of synphilin-1 A linkage study of candidate loci in familial Parkinson's Disease Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice Targeting heat shock proteins to modulate α-synuclein toxicity Genetically engineered mouse models of Parkinson's disease The benefits of humanized yeast models to study Parkinson's disease Structures of segments of α-synuclein fused to maltose-binding protein suggest intermediate states during amyloid formation C-Terminal Tyrosine Residue Modifications Modulate the Protective Phosphorylation of Serine 129 of α-Synuclein in a Yeast Model of Parkinson's Disease.Alpha-synuclein structure, functions, and interactions Casein kinase II-mediated phosphorylation regulates alpha-synuclein/synphilin-1 interaction and inclusion body formation Association of the cytoskeletal GTP-binding protein Sept4/H5 with cytoplasmic inclusions found in Parkinson's disease and other synucleinopathies Aggresome formation and neurodegenerative diseases: therapeutic implications Subgroup-specific structural variation across 1,000 medulloblastoma genomes Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease The aetiology of idiopathic Parkinson's disease Formation of toxic oligomeric alpha-synuclein species in living cells Synphilin-1 binds ATP and regulates intracellular energy status Rat alpha-synuclein interacts with Tat binding protein 1, a component of the 26S proteasomal complex Genome-wide scan linkage analysis for Parkinson's disease: the European genetic study of Parkinson's disease Characterization of α-Synuclein Multimer Stoichiometry in Complex Biological Samples by Electrophoresis RuvbL1 and RuvbL2 enhance aggresome formation and disaggregate amyloid fibrils.Proteasome failure promotes positioning of lysosomes around the aggresome via local block of microtubule-dependent transport.Interactions between Tau and α-synuclein augment neurotoxicity in a Drosophila model of Parkinson's disease.An evaluation of the performance of HapMap SNP data in a Shanghai Chinese population: analyses of allele frequency, linkage disequilibrium pattern and tagging SNPs transferability on chromosome 1q21-q25 Substrate specificity of human kallikreins 1 and 6 determined by phage display.Synphilin-1 enhances α-synuclein aggregation in yeast and contributes to cellular stress and cell death in a Sir2-dependent manner Alpha-synuclein in Lewy body disease and Alzheimer's disease.Misfolded polypeptides are selectively recognized and transported toward aggresomes by a CED complex Synphilin-1 attenuates neuronal degeneration in the A53T alpha-synuclein transgenic mouse model

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P2860

Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions

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1999 nî lūn-bûn

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1999 թուականի Մայիսին հրատարակուած գիտական յօդուած

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1999 թվականի մայիսին հրատարակված գիտական հոդված

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A A Lanahan

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A H Sharp

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10.1038/8820

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