MDM2 and MDMX bind and stabilize the p53-related protein p73
about
The ubiquitin-protein ligase Itch regulates p73 stabilityMdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development.MDM4 (MDMX) overexpression enhances stabilization of stress-induced p53 and promotes apoptosisA C-terminal inhibitory domain controls the activity of p63 by an intramolecular mechanism.MicroRNA-221 regulates chondrogenic differentiation through promoting proteosomal degradation of slug by targeting Mdm2Activation and activities of the p53 tumour suppressor proteinCombined p53-related genetic variants together with HPV infection increase oral cancer riskMDM4 (MDMX) and its Transcript Variants.C-terminal ubiquitination of p53 contributes to nuclear exportAmplification and overexpression of mdm2 gene in ependymomas.From p63 to p53 across p73.Differential contribution of inhibitory phosphorylation of CDC2 and CDK2 for unperturbed cell cycle control and DNA integrity checkpoints.Inhibiting the p53-MDM2 interaction: an important target for cancer therapy.Ubiquitin and ubiquitin-like modifications of the p53 family.A small-molecule p53 activator induces apoptosis through inhibiting MDMX expression in breast cancer cells.Regulation of p73 activity by post-translational modifications.Ubiquitin-dependent degradation of p73 is inhibited by PML.How many mutant p53 molecules are needed to inactivate a tetramer?p53-family proteins and their regulators: hubs and spokes in tumor suppression.Pirh2 RING-finger E3 ubiquitin ligase: its role in tumorigenesis and cancer therapy.Mdm2 and MdmX as Regulators of Gene ExpressionMDM2's social network.How the TP53 family proteins TP63 and TP73 contribute to tumorigenesis: regulators and effectors.Alterations of p63 and p73 in human cancers.p73-Binding Partners and Their Functional Significance.MDMX (MDM4), a Promising Target for p53 Reactivation Therapy and Beyond.Ribosomal proteins L11 and L5 activate TAp73 by overcoming MDM2 inhibition.Pirh2 E3 ubiquitin ligase modulates keratinocyte differentiation through p63.The p53 isoforms are differentially modified by Mdm2.A small-molecule inhibitor of MDMX activates p53 and induces apoptosis.TIP60 represses transcriptional activity of p73beta via an MDM2-bridged ternary complex.MDM2 chaperones the p53 tumor suppressor.p19ras interacts with and activates p73 by involving the MDM2 protein.p53 Activity Dominates That of p73 upon Mdm4 Loss in Development and Tumorigenesis.c-Jun regulates the stability and activity of the p53 homologue, p73.MDM2 mediates p300/CREB-binding protein-associated factor ubiquitination and degradation.Cyclin-dependent kinases phosphorylate p73 at threonine 86 in a cell cycle-dependent manner and negatively regulate p73.Regulation of the p53 homolog p73 by adenoviral oncogene E1A.The human MDM2 oncoprotein increases the transcriptional activity and the protein level of the p53 homolog p63.The Many Faces of MDM2 Binding Partners.
P2860
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P2860
MDM2 and MDMX bind and stabilize the p53-related protein p73
description
1999 nî lūn-bûn
@nan
1999 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
name
MDM2 and MDMX bind and stabilize the p53-related protein p73
@ast
MDM2 and MDMX bind and stabilize the p53-related protein p73
@en
MDM2 and MDMX bind and stabilize the p53-related protein p73
@en-gb
MDM2 and MDMX bind and stabilize the p53-related protein p73
@nl
type
label
MDM2 and MDMX bind and stabilize the p53-related protein p73
@ast
MDM2 and MDMX bind and stabilize the p53-related protein p73
@en
MDM2 and MDMX bind and stabilize the p53-related protein p73
@en-gb
MDM2 and MDMX bind and stabilize the p53-related protein p73
@nl
prefLabel
MDM2 and MDMX bind and stabilize the p53-related protein p73
@ast
MDM2 and MDMX bind and stabilize the p53-related protein p73
@en
MDM2 and MDMX bind and stabilize the p53-related protein p73
@en-gb
MDM2 and MDMX bind and stabilize the p53-related protein p73
@nl
P2093
P50
P1433
P1476
MDM2 and MDMX bind and stabilize the p53-related protein p73
@en
P2093
P304
P356
10.1016/S0960-9822(99)80367-4
P407
P577
1999-07-01T00:00:00Z