From mouse to human: evolutionary genomics analysis of human orthologs of essential genes
about
Cross-Species Integrative Functional Genomics in GeneWeaver Reveals a Role for Pafah1b1 in Altered Response to Alcohol.Understanding rare and common diseases in the context of human evolutionCancer evolution is associated with pervasive positive selection on globally expressed genesSharing and Specificity of Co-expression Networks across 35 Human TissuesDEG 10, an update of the database of essential genes that includes both protein-coding genes and noncoding genomic elementsA Systems Approach to Elucidate Heterosis of Protein Abundances in YeastAn expanded sequence context model broadly explains variability in polymorphism levels across the human genomePrioritizing genes for X-linked diseases using population exome data.Genic intolerance to functional variation and the interpretation of personal genomesProperties of human disease genes and the role of genes linked to Mendelian disorders in complex disease aetiology.In silico re-identification of properties of drug target proteinsTraining set selection for the prediction of essential genesVariation and genetic control of gene expression in primary immunocytes across inbred mouse strains.The Hsp90-dependent proteome is conserved and enriched for hub proteins with high levels of protein-protein connectivity.Profiling the transcription factor regulatory networks of human cell types.Hierarchical partitioning of metazoan protein conservation profiles provides new functional insights.Investigating different duplication pattern of essential genes in mouse and human.Determining minimum set of driver nodes in protein-protein interaction networks.Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.Analysis of loss-of-function variants and 20 risk factor phenotypes in 8,554 individuals identifies loci influencing chronic diseaseHigh-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes.Spatiotemporal dynamics of the postnatal developing primate brain transcriptome.Translational control by lysine-encoding A-rich sequences.Disparate Modes of Evolution Shaped Modern Prion (PRNP) and Prion-Related Doppel (PRND) Variation in Domestic CattleNew genes drive the evolution of gene interaction networks in the human and mouse genomesComparative analysis of housekeeping and tissue-specific driver nodes in human protein interaction networks.Cell type-selective disease-association of genes under high regulatory load.Systematic analysis of gene properties influencing organ system phenotypes in mammalian perturbations.Differential variation patterns between hubs and bottlenecks in human protein-protein interaction networks.An Asymmetrically Balanced Organization of Kinases versus Phosphatases across Eukaryotes Determines Their Distinct ImpactsEstimating the selective effects of heterozygous protein-truncating variants from human exome data.DIDA: A curated and annotated digenic diseases database.Identification of Human Neuronal Protein Complexes Reveals Biochemical Activities and Convergent Mechanisms of Action in Autism Spectrum DisordersWhole-exome sequencing in undiagnosed genetic diseases: interpreting 119 trios.Towards a compendium of essential genes - From model organisms to synthetic lethality in cancer cells.Germline De Novo Mutations in GNB1 Cause Severe Neurodevelopmental Disability, Hypotonia, and Seizures.PiggyBac transposon-based polyadenylation-signal trap for genome-wide mutagenesis in mice.Differential burden of rare protein truncating variants in Alzheimer's disease patients compared to centenarians.Increased burden of deleterious variants in essential genes in autism spectrum disorder.High-throughput discovery of novel developmental phenotypes.
P2860
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P2860
From mouse to human: evolutionary genomics analysis of human orthologs of essential genes
description
2013 nî lūn-bûn
@nan
2013 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
From mouse to human: evolutionary genomics analysis of human orthologs of essential genes
@ast
From mouse to human: evolutionary genomics analysis of human orthologs of essential genes
@en
From mouse to human: evolutionary genomics analysis of human orthologs of essential genes
@en-gb
From mouse to human: evolutionary genomics analysis of human orthologs of essential genes
@nl
type
label
From mouse to human: evolutionary genomics analysis of human orthologs of essential genes
@ast
From mouse to human: evolutionary genomics analysis of human orthologs of essential genes
@en
From mouse to human: evolutionary genomics analysis of human orthologs of essential genes
@en-gb
From mouse to human: evolutionary genomics analysis of human orthologs of essential genes
@nl
prefLabel
From mouse to human: evolutionary genomics analysis of human orthologs of essential genes
@ast
From mouse to human: evolutionary genomics analysis of human orthologs of essential genes
@en
From mouse to human: evolutionary genomics analysis of human orthologs of essential genes
@en-gb
From mouse to human: evolutionary genomics analysis of human orthologs of essential genes
@nl
P2860
P3181
P1433
P1476
From mouse to human: evolutionary genomics analysis of human orthologs of essential genes
@en
P2093
Benjamin Georgi
Maja Bućan
P2860
P304
P3181
P356
10.1371/JOURNAL.PGEN.1003484
P407
P577
2013-05-01T00:00:00Z