Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres
about
Human single-stranded DNA binding proteins are essential for maintaining genomic stabilityMre11 complex and DNA replication: linkage to E2F and sites of DNA synthesisThe telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182)Targeting assay to study the cis functions of human telomeric proteins: evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2Rap1 affects the length and heterogeneity of human telomeresSuppression of alternative lengthening of telomeres by Sp100-mediated sequestration of the MRE11/RAD50/NBS1 complex.A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assemblyInterplay between human DNA repair proteins at a unique double-strand break in vivoTelomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicasesTelosome, a mammalian telomere-associated complex formed by multiple telomeric proteinsGenome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cellsWRN controls formation of extrachromosomal telomeric circles and is required for TRF2DeltaB-mediated telomere shorteningA quantitative telomeric chromatin isolation protocol identifies different telomeric statesIn vivo stoichiometry of shelterin componentsThe SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteinsMRE11-RAD50-NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repairRAD50 and NBS1 form a stable complex functional in DNA binding and tetheringComplementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2The human Rap1 protein complex and modulation of telomere lengthInvolvement of telomerase reverse transcriptase in heterochromatin maintenanceATRX dysfunction induces replication defects in primary mouse cellsMammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres.Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpointMultiple roles of ATM in monitoring and maintaining DNA integrityShelterin complex and associated factors at human telomeresTelomere dysfunction and chromosome instabilityBRCA1 inhibition of telomerase activity in cultured cellsHuman Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubulesTelomere and ribosomal DNA repeats are chromosomal targets of the bloom syndrome DNA helicaseThe telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage responseNucleases in homologous recombination as targets for cancer therapyTelomere shortening in human diseasesCausal link between microsatellite instability and hMRE11 dysfunction in human cancersA shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteinsXrs2p regulates Mre11p translocation to the nucleus and plays a role in telomere elongation and meiotic recombination.Two survivor pathways that allow growth in the absence of telomerase are generated by distinct telomere recombination events.Nucleostemin prevents telomere damage by promoting PML-IV recruitment to SUMOylated TRF1MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length controlHuman Ku70/80 associates physically with telomerase through interaction with hTERTThe involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs at human telomeres
P2860
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P2860
Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres
description
2000 nî lūn-bûn
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2000 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres
@ast
Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres
@en
Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres
@en-gb
Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres
@nl
type
label
Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres
@ast
Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres
@en
Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres
@en-gb
Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres
@nl
prefLabel
Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres
@ast
Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres
@en
Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres
@en-gb
Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres
@nl
P50
P921
P3181
P356
P1433
P1476
Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres
@en
P2093
P2888
P304
P3181
P356
10.1038/77139
P407
P577
2000-07-01T00:00:00Z
P5875
P6179
1036725450