about
Sirtuins: Sir2-related NAD-dependent protein deacetylasesGenealogy of an ancient protein family: the Sirtuins, a family of disordered membersHuman SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence.Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycleDeacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradationCrystal structures of human SIRT3 displaying substrate-induced conformational changesStructural basis for nicotinamide cleavage and ADP-ribose transfer by NAD(+)-dependent Sir2 histone/protein deacetylasesSynthesis and evaluation of substituted chroman-4-one and chromone derivatives as sirtuin 2-selective inhibitorsEvolution of the arginase fold and functional diversityInvolvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repressionPotential Modulation of Sirtuins by Oxidative StressStructural basis for sirtuin activity and inhibitionProtective effects and mechanisms of sirtuins in the nervous systemSirtuin 1 and sirtuin 3: physiological modulators of metabolismThe role of mammalian sirtuins in the regulation of metabolism, aging, and longevitySirtuins in epigenetic regulationGroup IVA Cytosolic Phospholipase A2 Regulates the G2-to-M Transition by Modulating the Activity of Tumor Suppressor SIRT2.C. elegans SIRT6/7 homolog SIR-2.4 promotes DAF-16 relocalization and function during stressStructural basis for the NAD-dependent deacetylase mechanism of Sir2Structural Insights into Intermediate Steps in the Sir2 Deacetylation ReactionStructure of Sir2Tm bound to a propionylated peptidePlasmodium falciparum Sir2A Preferentially Hydrolyzes Medium and Long Chain Fatty Acyl LysineA Molecular Mechanism for Direct Sirtuin Activation by ResveratrolStructural basis for allosteric stimulation of Sir2 activity by Sir4 bindingStructural and Functional Analysis of Human SIRT1Longevity regulation in Saccharomyces cerevisiae: linking metabolism, genome stability, and heterochromatinDomain structure and protein interactions of the silent information regulator Sir3 revealed by screening a nested deletion library of protein fragments.The role of sirtuins in cellular homeostasisConserved enzymatic production and biological effect of O-acetyl-ADP-ribose by silent information regulator 2-like NAD+-dependent deacetylasesSIRT2 suppresses adipocyte differentiation by deacetylating FOXO1 and enhancing FOXO1's repressive interaction with PPARgammaIdentification of a small molecule inhibitor of Sir2pOxygen consumption and usage during physical exercise: the balance between oxidative stress and ROS-dependent adaptive signalingIdentification of inhibitor binding site in human sirtuin 2 using molecular docking and dynamics simulationsComputational studies on sirtuins from Trypanosoma cruzi: structures, conformations and interactions with phytochemicalsThe Nuts and Bolts of Transcriptionally Silent Chromatin in Saccharomyces cerevisiae.Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.Damped-dynamics flexible fitting.Prokaryotic homologs of Argonaute proteins are predicted to function as key components of a novel system of defense against mobile genetic elements.Modulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectivestRNA synthetase counteracts c-Myc to develop functional vasculature.
P2860
Q21092883-49CF2B0A-C1D6-4BF3-8B5D-19A45DF3C519Q21284005-9A9214FF-46F7-4D2C-8C33-5666E33BB86DQ24297146-2A45D578-0ED1-495F-80E4-DBA05A703A07Q24299947-775C5A42-67D5-41FD-B5D9-C23C899131C1Q24322745-EB2DFB42-9981-4782-8740-F34EA2C33316Q24338623-E32D0EB4-0F75-4DF9-9B6C-85521B915B22Q24564290-30C8A11E-3B50-4253-AC99-33014BAE8980Q24613541-D0CA7D52-87C0-4B47-89CF-2A5C49ABC2E6Q24642568-8CD6BBF4-FBED-4A93-A455-30304BD0B517Q24650557-690AE649-1E0D-40EA-984B-62D04F5CA86CQ26770803-B1FF25D7-6AF7-43E0-A895-0C3CE2060ED2Q26823308-B55D94ED-F87C-4EB0-9343-2EF50C2F3BC3Q26825585-C7F1641A-8A23-4C6F-8021-852615A0E044Q26828607-B0991609-E2A7-4925-A31C-F596C76498D7Q26865526-0269A7E4-4A93-4A1B-B01B-38392A7DA211Q27026861-DBF5CC03-04A9-46A8-B7AA-4444D830EBB5Q27320850-ADFEFA44-CBEB-444F-9C85-EC3E06174ACCQ27331617-1DEF6838-7A8F-4619-88DB-F8A6232CA1E6Q27639274-60A8741D-B383-4DB9-82F4-3CC340E9FCB3Q27652097-5BAF8A43-5510-4CDC-9B89-4CED4D8ECC38Q27665904-22BC12CC-4392-4134-A865-42D170EA9564Q27674991-51CC093B-98A3-4DB5-B563-BA9CF050DF09Q27675270-EADD22B5-4AC4-49C0-BF24-0B2EB88B219AQ27675868-B022856F-5AA5-4611-8919-7E5C5A7E3807Q27680242-CB7BDF3A-60D5-4A88-A4A3-E95C4C98059AQ27931533-D89D4BDC-1454-46C0-89E2-5C63D97C8FF2Q27935281-CA18F286-BF15-45E3-9864-46E6C64831A1Q28075581-AA31218C-F287-4162-8F9B-66AF22CF2837Q28216739-09B9A48D-5CBC-466B-B423-7076E9456218Q28301961-F9CC99C9-9801-4F0D-AAC0-E63E1142A53BQ28344005-E9D564A7-9402-4BEA-83EE-0E8369D4E27CQ28394742-04191457-1355-4709-8CF5-06F78EF5D34DQ28485339-315FD486-2EC1-41BB-9085-AC19DCB4289CQ28539769-ECF7AB19-7F9B-46C9-A8F4-042E1BC4A2BFQ30276142-889EA4D0-46B1-43A0-94B3-5D32AD28AD78Q30316777-A5749F65-DA95-49C7-A553-CE889EE9C2E9Q30438274-130066FA-9CD4-40C4-84BA-0EBFE4830B45Q30490196-731C4A39-75F1-4026-B08F-807309DC988CQ30570945-4BB1750A-B3E7-449E-AFA7-62CDE6CD0254Q31814854-624B2EEE-A891-44FE-A531-F195192E3B32
P2860
description
2001 nî lūn-bûn
@nan
2001 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Structure of the histone deacetylase SIRT2
@ast
Structure of the histone deacetylase SIRT2
@en
Structure of the histone deacetylase SIRT2
@en-gb
Structure of the histone deacetylase SIRT2
@nl
type
label
Structure of the histone deacetylase SIRT2
@ast
Structure of the histone deacetylase SIRT2
@en
Structure of the histone deacetylase SIRT2
@en-gb
Structure of the histone deacetylase SIRT2
@nl
prefLabel
Structure of the histone deacetylase SIRT2
@ast
Structure of the histone deacetylase SIRT2
@en
Structure of the histone deacetylase SIRT2
@en-gb
Structure of the histone deacetylase SIRT2
@nl
P2093
P921
P3181
P356
P1476
Structure of the histone deacetylase SIRT2
@en
P2093
J R Donigian
M S Finnin
N P Pavletich
P2888
P3181
P356
10.1038/89668
P407
P577
2001-07-01T00:00:00Z
P5875
P6179
1032129634