Subcellular localization and tumor-suppressive functions of 15-lipoxygenase 2 (15-LOX2) and its splice variants
about
15-lipoxygenase metabolites of docosahexaenoic acid inhibit prostate cancer cell proliferation and survivalHuman and mouse eLOX3 have distinct substrate specificities: implications for their linkage with lipoxygenases in skinInverse relationship between 15-lipoxygenase-2 and PPAR-gamma gene expression in normal epithelia compared with tumor epitheliaMammalian lipoxygenases and their biological relevanceArachidonic acid metabolism in human prostate cancerA high throughput screen identifies potent and selective inhibitors to human epithelial 15-lipoxygenase-2Association of active caspase 8 with the mitochondrial membrane during apoptosis: potential roles in cleaving BAP31 and caspase 3 and mediating mitochondrion-endoplasmic reticulum cross talk in etoposide-induced cell deathA kernel-based integration of genome-wide data for clinical decision support.15(S)-hydroxyeicosatetraenoic acid-induced angiogenesis requires Src-mediated Egr-1-dependent rapid induction of FGF-2 expression.Tumor-suppressive functions of 15-Lipoxygenase-2 and RB1CC1 in prostate cancerDownregulation of vascular endothelial growth factor and induction of tumor dormancy by 15-lipoxygenase-2 in prostate cancerEvidence that Sp1 positively and Sp3 negatively regulate and androgen does not directly regulate functional tumor suppressor 15-lipoxygenase 2 (15-LOX2) gene expression in normal human prostate epithelial cells.15-Lipoxygenase-2 gene regulation by its product 15-(S)-hydroxyeicosatetraenoic acid through a negative feedback mechanism that involves peroxisome proliferator-activated receptor gamma.PPARγ: a molecular link between systemic metabolic disease and benign prostate hyperplasia.The Intracellular Localisation and Phosphorylation Profile of the Human 5-Lipoxygenase Δ13 Isoform Differs from That of Its Full Length CounterpartcPLA(2)α gene activation by IL-1β is dependent on an upstream kinase pathway, enzymatic activation and downstream 15-lipoxygenase activity: a positive feedback loopBim, a proapoptotic protein, up-regulated via transcription factor E2F1-dependent mechanism, functions as a prosurvival molecule in cancer.Dietary n-3 polyunsaturated fatty acids enhance hormone ablation therapy in androgen-dependent prostate cancerA novel role for activating transcription factor-2 in 15(S)-hydroxyeicosatetraenoic acid-induced angiogenesis.The 15(S)-hydroxyeicosatetraenoic acid-induced angiogenesis requires Janus kinase 2-signal transducer and activator of transcription-5B-dependent expression of interleukin-8.Tumor-suppressive lipoxygenases inhibit the expression of c-myc mRNA coding region determinant-binding protein/insulin-like growth factor II mRNA-binding protein 1 in human prostate carcinoma PC-3 cells.Critical and distinct roles of p16 and telomerase in regulating the proliferative life span of normal human prostate epithelial progenitor cells.Genetic variation in the eicosanoid pathway is associated with non-small-cell lung cancer (NSCLC) survival.An antitumorigenic role for murine 8S-lipoxygenase in skin carcinogenesis.Arachidonic acid pathway members PLA2G7, HPGD, EPHX2, and CYP4F8 identified as putative novel therapeutic targets in prostate cancer.Transgenic expression of 15-lipoxygenase 2 (15-LOX2) in mouse prostate leads to hyperplasia and cell senescence.Cell-autonomous induction of functional tumor suppressor 15-lipoxygenase 2 (15-LOX2) contributes to replicative senescence of human prostate progenitor cells.Tumor-suppressing 15-lipoxygenase-2: time for prime time?Inflammation, Cancer and Oxidative Lipoxygenase Activity are Intimately Linked.
P2860
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P2860
Subcellular localization and tumor-suppressive functions of 15-lipoxygenase 2 (15-LOX2) and its splice variants
description
2003 nî lūn-bûn
@nan
2003 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Subcellular localization and t ...... -LOX2) and its splice variants
@ast
Subcellular localization and t ...... -LOX2) and its splice variants
@en
Subcellular localization and t ...... -LOX2) and its splice variants
@en-gb
Subcellular localization and t ...... -LOX2) and its splice variants
@nl
type
label
Subcellular localization and t ...... -LOX2) and its splice variants
@ast
Subcellular localization and t ...... -LOX2) and its splice variants
@en
Subcellular localization and t ...... -LOX2) and its splice variants
@en-gb
Subcellular localization and t ...... -LOX2) and its splice variants
@nl
prefLabel
Subcellular localization and t ...... -LOX2) and its splice variants
@ast
Subcellular localization and t ...... -LOX2) and its splice variants
@en
Subcellular localization and t ...... -LOX2) and its splice variants
@en-gb
Subcellular localization and t ...... -LOX2) and its splice variants
@nl
P2093
P2860
P356
P1476
Subcellular localization and t ...... -LOX2) and its splice variants
@en
P2093
Bobby Bhatia
Carlos J Maldonado
Dean G Tang
Dharam Chopra
Dhyan Chandra
Peiying Yang
Robert A Newman
Russell D Klein
Scott B Shappell
Shaohua Tang
P2860
P304
P356
10.1074/JBC.M301920200
P407
P577
2003-07-04T00:00:00Z