Functional interactions between the ciliopathy-associated Meckel syndrome 1 (MKS1) protein and two novel MKS1-related (MKSR) proteins
about
TMEM237 is mutated in individuals with a Joubert syndrome related disorder and expands the role of the TMEM family at the ciliary transition zoneBardet-Biedl syndrome-associated small GTPase ARL6 (BBS3) functions at or near the ciliary gate and modulates Wnt signalingMapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathwaysNephrocystins and MKS proteins interact with IFT particle and facilitate transport of selected ciliary cargosIdentification of novel families and classification of the C2 domain superfamily elucidate the origin and evolution of membrane targeting activities in eukaryotesThe hydrolethalus syndrome protein HYLS-1 links core centriole structure to cilia formationThe base of the cilium: roles for transition fibres and the transition zone in ciliary formation, maintenance and compartmentalizationCompartments within a compartment: what C. elegans can tell us about ciliary subdomain composition, biogenesis, function, and diseaseMKS5 and CEP290 Dependent Assembly Pathway of the Ciliary Transition ZoneThe small GTPases ARL-13 and ARL-3 coordinate intraflagellar transport and ciliogenesisMKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesisA ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain.Disruption of a ciliary B9 protein complex causes Meckel syndromeA mouse model for Meckel syndrome reveals Mks1 is required for ciliogenesis and Hedgehog signalingSensory perception and aging in model systems: from the outside in.Transmembrane protein OSTA-1 shapes sensory cilia morphology via regulation of intracellular membrane trafficking in C. elegans.From the cytoplasm into the cilium: bon voyage.Diverse cell type-specific mechanisms localize G protein-coupled receptors to Caenorhabditis elegans sensory ciliaNormal ciliogenesis requires synergy between the cystic kidney disease genes MKS-3 and NPHP-4.Ciliopathies: the trafficking connection.B9D1 is revealed as a novel Meckel syndrome (MKS) gene by targeted exon-enriched next-generation sequencing and deletion analysisCiliary diffusion barrier: the gatekeeper for the primary cilium compartment.TMEM231, mutated in orofaciodigital and Meckel syndromes, organizes the ciliary transition zone.Drosophila chibby is required for basal body formation and ciliogenesis but not for Wg signaling.Ciliogenesis in Caenorhabditis elegans requires genetic interactions between ciliary middle segment localized NPHP-2 (inversin) and transition zone-associated proteins.The Meckel syndrome- associated protein MKS1 functionally interacts with components of the BBSome and IFT complexes to mediate ciliary trafficking and hedgehog signalingPACRG, a protein linked to ciliary motility, mediates cellular signalingCell- and subunit-specific mechanisms of CNG channel ciliary trafficking and localization in C. elegans.Transition zone assembly and its contribution to axoneme formation in Drosophila male germ cells.Drosophila sensory cilia lacking MKS proteins exhibit striking defects in development but only subtle defects in adults.Transcriptional profiling of C. elegans DAF-19 uncovers a ciliary base-associated protein and a CDK/CCRK/LF2p-related kinase required for intraflagellar transport.Transcriptional control of genes involved in ciliogenesis: a first step in making cilia.Molecular genetics and pathogenic mechanisms for the severe ciliopathies: insights into neurodevelopment and pathogenesis of neural tube defects.Small GTPases and ciliaMeckel-Gruber syndrome and the role of primary cilia in kidney, skeleton, and central nervous system developmentCiliary subcompartments and cysto-proteins.Genetics of human Bardet-Biedl syndrome, an updates.Ciliary dysfunction impairs beta-cell insulin secretion and promotes development of type 2 diabetes in rodents.Evidence for a role of the ciliopathy protein MKS1 in cell polarity.
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P2860
Functional interactions between the ciliopathy-associated Meckel syndrome 1 (MKS1) protein and two novel MKS1-related (MKSR) proteins
description
2009 nî lūn-bûn
@nan
2009 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մարտին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Functional interactions betwee ...... l MKS1-related (MKSR) proteins
@ast
Functional interactions betwee ...... l MKS1-related (MKSR) proteins
@en
Functional interactions betwee ...... l MKS1-related (MKSR) proteins
@en-gb
Functional interactions betwee ...... l MKS1-related (MKSR) proteins
@nl
type
label
Functional interactions betwee ...... l MKS1-related (MKSR) proteins
@ast
Functional interactions betwee ...... l MKS1-related (MKSR) proteins
@en
Functional interactions betwee ...... l MKS1-related (MKSR) proteins
@en-gb
Functional interactions betwee ...... l MKS1-related (MKSR) proteins
@nl
prefLabel
Functional interactions betwee ...... l MKS1-related (MKSR) proteins
@ast
Functional interactions betwee ...... l MKS1-related (MKSR) proteins
@en
Functional interactions betwee ...... l MKS1-related (MKSR) proteins
@en-gb
Functional interactions betwee ...... l MKS1-related (MKSR) proteins
@nl
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P2860
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Functional interactions betwee ...... l MKS1-related (MKSR) proteins
@en
P2093
Chrystal D Inglis
Chunmei Li
David C Cottell
Erica E Davis
Jeremy D K Parker
Jon F Robinson
Michael P Healey
Michel R Leroux
Nathan J Bialas
Peter N Inglis
P2860
P304
P3181
P356
10.1242/JCS.028621
P407
P577
2009-03-01T00:00:00Z