Erythroid Krüppel-like factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5'HS3 of the beta-globin locus control region
about
Functional cross-antagonism between transcription factors FLI-1 and EKLFTranscriptional profiling of Krüppel-like factor 4 reveals a function in cell cycle regulation and epithelial differentiationA global role for EKLF in definitive and primitive erythropoiesisThe active spatial organization of the beta-globin locus requires the transcription factor EKLFThe erythroid phenotype of EKLF-null mice: defects in hemoglobin metabolism and membrane stabilitySubcellular transport of EKLF and switch-on of murine adult beta maj globin gene transcription.Unique in vitro and in vivo thrombopoietic activities of ingenol 3,20 dibenzoate, a Ca(++)-independent protein kinase C isoform agonist.Role of chromatin structure and distal enhancers in tissue-specific transcriptional regulation in vitro.Adult stage gamma-globin silencing is mediated by a promoter direct repeat element.Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencingTranscriptional control of erythropoiesis: emerging mechanisms and principles.Alterations in expression and chromatin configuration of the alpha hemoglobin-stabilizing protein gene in erythroid Kruppel-like factor-deficient mice.Transcriptional regulation of erythropoiesis. Fine tuning of combinatorial multi-domain elements.Beta-globin locus control region HS2 and HS3 interact structurally and functionallyBeta-Actin Is Involved in Modulating Erythropoiesis during Development by Fine-Tuning Gata2 Expression Levels.Resveratrol ameliorates TNFα-mediated suppression of erythropoiesis in human CD34(+) cells via modulation of NF-κB signalling.Context-dependent EKLF responsiveness defines the developmental specificity of the human epsilon-globin gene in erythroid cells of YAC transgenic mice.The multifunctional role of EKLF/KLF1 during erythropoiesis.Erythroid-Specific Expression of LIN28A Is Sufficient for Robust Gamma-Globin Gene and Protein Expression in Adult Erythroblasts.An mSin3A interaction domain links the transcriptional activity of KLF11 with its role in growth regulation.Long-range chromosomal interactions and gene regulationAdvances in the understanding of haemoglobin switching.EKLF/KLF1, a tissue-restricted integrator of transcriptional control, chromatin remodeling, and lineage determination.Failure of terminal erythroid differentiation in EKLF-deficient mice is associated with cell cycle perturbation and reduced expression of E2F2.Activation of the beta globin locus by transcription factors and chromatin modifiers.Unanticipated repression function linked to erythroid Krüppel-like factor.HS5 of the human beta-globin locus control region: a developmental stage-specific border in erythroid cells.Acetylation of EKLF is essential for epigenetic modification and transcriptional activation of the beta-globin locus.Non-random subcellular distribution of variant EKLF in erythroid cells.Novel role for EKLF in megakaryocyte lineage commitment.Chromatin-binding in vivo of the erythroid kruppel-like factor, EKLF, in the murine globin loci.Altered DNA-binding specificity mutants of EKLF and Sp1 show that EKLF is an activator of the beta-globin locus control region in vivo.Kruppel-like factor 4 regulates laminin alpha 3A expression in mammary epithelial cells.Novel transactivation domain in erythroid Kruppel-like factor (EKLF).Chromatin interaction mechanism of transcriptional control in vivo.Cryptic splicing sites are differentially utilized in vivo.Flicking the switch: adult hemoglobin expression in erythroid cells derived from cord blood and human induced pluripotent stem cells.In vivo formation of a human beta-globin locus control region core element requires binding sites for multiple factors including GATA-1, NF-E2, erythroid Kruppel-like factor, and Sp1.The intrinsic genetic and epigenetic regulator factors as therapeutic targets, and the effect on fetal globin gene expression.
P2860
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P2860
Erythroid Krüppel-like factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5'HS3 of the beta-globin locus control region
description
1998 nî lūn-bûn
@nan
1998 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Erythroid Krüppel-like factor ...... ta-globin locus control region
@ast
Erythroid Krüppel-like factor ...... ta-globin locus control region
@en
Erythroid Krüppel-like factor ...... ta-globin locus control region
@en-gb
Erythroid Krüppel-like factor ...... ta-globin locus control region
@nl
type
label
Erythroid Krüppel-like factor ...... ta-globin locus control region
@ast
Erythroid Krüppel-like factor ...... ta-globin locus control region
@en
Erythroid Krüppel-like factor ...... ta-globin locus control region
@en-gb
Erythroid Krüppel-like factor ...... ta-globin locus control region
@nl
prefLabel
Erythroid Krüppel-like factor ...... ta-globin locus control region
@ast
Erythroid Krüppel-like factor ...... ta-globin locus control region
@en
Erythroid Krüppel-like factor ...... ta-globin locus control region
@en-gb
Erythroid Krüppel-like factor ...... ta-globin locus control region
@nl
P2093
P2860
P356
P1433
P1476
Erythroid Krüppel-like factor ...... ta-globin locus control region
@en
P2093
F Grosveld
M Wijgerde
M von Lindern
N Gillemans
S Philipsen
P2860
P304
P356
10.1093/EMBOJ/17.8.2334
P407
P577
1998-04-15T00:00:00Z