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An immunologically privileged retinal antigen elicits tolerance: major role for central selection mechanisms

An immunologically privileged retinal antigen elicits tolerance: major role for central selection mechanisms

http://www.wikidata.org/entity/Q24672886

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Deaf1 isoforms control the expression of genes encoding peripheral tissue antigens in the pancreatic lymph nodes during type 1 diabetes A look at autoimmunity and inflammation in the eye Parainflammation, chronic inflammation, and age-related macular degeneration Inducible immune regulation following autoimmune disease in the immune-privileged eye Generation of Regulatory T Cells to Antigen Expressed in the Retina.Galectin-8 Ameliorates Murine Autoimmune Ocular Pathology and Promotes a Regulatory T Cell Response.A novel pathogenic RBP-3 peptide reveals epitope spreading in persistent experimental autoimmune uveoretinitis.The living eye "disarms" uncommitted autoreactive T cells by converting them to Foxp3(+) regulatory cells following local antigen recognition.Supplementation of CD4+CD25+ regulatory T cells suppresses experimental autoimmune uveoretinitis.Self-representation in the thymus: an extended view.Spontaneous autoimmunity prevented by thymic expression of a single self-antigen Endogenous IRBP can be dispensable for generation of natural CD4+CD25+ regulatory T cells that protect from IRBP-induced retinal autoimmunity Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels Ocular autoimmunity: the price of privilege?Thymic expression of peripheral tissue antigens in humans: a remarkable variability among individuals Repertoire analysis and new pathogenic epitopes of IRBP in C57BL/6 (H-2b) and B10.RIII (H-2r) mice Activation of invariant NKT cells ameliorates experimental ocular autoimmunity by a mechanism involving innate IFN-gamma production and dampening of the adaptive Th1 and Th17 responses Autoimmunity in the immune privileged eye: pathogenic and regulatory T cells Targeting the complement system for the management of retinal inflammatory and degenerative diseases.Peripheral induction of tolerance by retinal antigen expression Hydrodynamic vaccination with DNA encoding an immunologically privileged retinal antigen protects from autoimmunity through induction of regulatory T cells.Immune tolerance and autoimmune uveoretinitis: the role of the ocular microenvironment.Increased frequency of anti-retina antibodies in asymptomatic patients with chronic t. gondii infection.Regulation of CD8(+) T Cell Responses to Retinal Antigen by Local FoxP3(+) Regulatory T Cells.Expression of self-antigen in the thymus: a little goes a long way.Understanding autoimmune uveitis through animal models. The Friedenwald Lecture.Retinal antigen-specific regulatory T cells protect against spontaneous and induced autoimmunity and require local dendritic cells.Lymphopenia-induced proliferation is a potent activator for CD4+ T cell-mediated autoimmune disease in the retina.Ocular antigen does not cause disease unless presented in the context of inflammation.Peripheral expression of rod photoreceptor arrestin induces an epitope-specific, protective response against experimental autoimmune uveoretinitis.Tolerance Induction in Relation to the Eye New insight into the role of the complement in the most common types of retinopathy-current literature review

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P2860

An immunologically privileged retinal antigen elicits tolerance: major role for central selection mechanisms

http://www.wikidata.org/entity/Q24672886

description

2003 nî lūn-bûn

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2003 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2003 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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An immunologically privileged ...... r central selection mechanisms

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An immunologically privileged ...... r central selection mechanisms

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An immunologically privileged ...... r central selection mechanisms

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An immunologically privileged ...... r central selection mechanisms

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An immunologically privileged ...... r central selection mechanisms

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An immunologically privileged ...... r central selection mechanisms

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An immunologically privileged ...... r central selection mechanisms

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An immunologically privileged ...... r central selection mechanisms

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An immunologically privileged ...... r central selection mechanisms

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Barbara Wiggert

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Dody Avichezer

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Giavonni M Lewis

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Gregory I Liou

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James A Raber

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Larry A Donoso

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Mary J Mattapallil

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Phyllis B Silver

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Rafael S Grajewski

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P2860

Projection of an immunological self shadow within the thymus by the aire protein

Early onset photoreceptor abnormalities induced by targeted disruption of the interphotoreceptor retinoid-binding protein gene

Immune mechanisms in uveitis.

Cutting edge: depletion of CD4+CD25+ regulatory T cells is necessary, but not sufficient, for induction of organ-specific autoimmune disease.

Control of T-cell activation by CD4+ CD25+ suppressor T cells.

The eye's view of antigen presentation.

Promiscuous gene expression and central T-cell tolerance: more than meets the eye.

Anterior chamber associated immune deviation (ACAID): regulation, biological relevance, and implications for therapy.

High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: mechanisms of selection of the self-reactive repertoire.

Endogenous myelin basic protein inactivates the high avidity T cell repertoire

P304

1665-76

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10.1084/JEM.20030413

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11

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198

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8975182

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14657219

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2194140

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