Direct visualization of CHIP-mediated degradation of alpha-synuclein in vivo: implications for PD therapeutics

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A Rapid, Semi-Quantitative Assay to Screen for Modulators of Alpha-Synuclein Oligomerization Ex vivo.The Neuroprotective Role of Protein Quality Control in Halting the Development of Alpha-Synuclein Pathology.

P2860

Q36475337-CEF49845-35D9-4394-9076-08CD7511BC09 Q42288817-5AD6A21A-3B5C-4BAB-A305-BFA29B4A5B50

P2860

Direct visualization of CHIP-mediated degradation of alpha-synuclein in vivo: implications for PD therapeutics

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http://www.wikidata.org/entity/Q27314815

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2014 nî lūn-bûn

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2014 թուականին հրատարակուած գիտական յօդուած

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2014 թվականին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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Direct visualization of CHIP-m ...... plications for PD therapeutics

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Direct visualization of CHIP-m ...... plications for PD therapeutics

@en

Direct visualization of CHIP-m ...... plications for PD therapeutics

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Item

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Direct visualization of CHIP-m ...... plications for PD therapeutics

@ast

Direct visualization of CHIP-m ...... plications for PD therapeutics

@en

Direct visualization of CHIP-m ...... plications for PD therapeutics

@nl

prefLabel

Direct visualization of CHIP-m ...... plications for PD therapeutics

@ast

Direct visualization of CHIP-m ...... plications for PD therapeutics

@en

Direct visualization of CHIP-m ...... plications for PD therapeutics

@nl

P1476

Direct visualization of CHIP-m ...... plications for PD therapeutics

@en

P2093

Hemi Dimant

http://www.w3.org/2001/XMLSchema#string

Laura N Kibuuka

http://www.w3.org/2001/XMLSchema#string

Liya Zhu

http://www.w3.org/2001/XMLSchema#string

Pamela J McLean

http://www.w3.org/2001/XMLSchema#string

Zhanyun Fan

http://www.w3.org/2001/XMLSchema#string

P2860

Tyrosine hydroxylase and regulation of dopamine synthesis

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

Posttranslational quality control: folding, refolding, and degrading proteins.

Ubiquitinylation of α-synuclein by carboxyl terminus Hsp70-interacting protein (CHIP) is regulated by Bcl-2-associated athanogene 5 (BAG5).

C-terminus of heat shock protein 70-interacting protein facilitates degradation of apoptosis signal-regulating kinase 1 and inhibits apoptosis signal-regulating kinase 1-dependent apoptosis.

Novel role of C terminus of Hsc70-interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction via regulating ERK5-mediated degradation of inducible cAMP early repressor.

Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity.

In vivo demonstration that alpha-synuclein oligomers are toxic.

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e92098

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scholarly article

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10.1371/JOURNAL.PONE.0092098

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English

P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P50

Bradley Hyman

P577

2014-01-01T00:00:00Z

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P5875

261069322

http://www.w3.org/2001/XMLSchema#string

P698

24664141

http://www.w3.org/2001/XMLSchema#string

P921

Synuclein

visualization

P932

3963877

http://www.w3.org/2001/XMLSchema#string

Direct visualization of CHIP-mediated degradation of alpha-synuclein in vivo: implications for PD therapeutics

about

P2860

P2860

Direct visualization of CHIP-mediated degradation of alpha-synuclein in vivo: implications for PD therapeutics

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P1476

P2093

P2860

P304

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P356

P407

P433

P478

P50

P577

P5875

P698

P921

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P5875

P698

P921

P932