Cryo-EM structures of the eukaryotic replicative helicase bound to a translocation substrate.
about
Fundamental Characteristics of AAA+ Protein Family Structure and FunctionArchaeal orthologs of Cdc45 and GINS form a stable complex that stimulates the helicase activity of MCMCMG-Pol epsilon dynamics suggests a mechanism for the establishment of leading-strand synthesis in the eukaryotic replisome.Eukaryotic Replicative Helicase Subunit Interaction with DNA and Its Role in DNA Replication.Structure of human Cdc45 and implications for CMG helicase functionThe eukaryotic CMG helicase pumpjack and integration into the replisome.Chromosome Duplication in Saccharomyces cerevisiae.Mutations in CDC45, Encoding an Essential Component of the Pre-initiation Complex, Cause Meier-Gorlin Syndrome and Craniosynostosis.Unravelling biological macromolecules with cryo-electron microscopy.New insights into the GINS complex explain the controversy between existing structural models.Structure of eukaryotic CMG helicase at a replication fork and implications to replisome architecture and origin initiation.Mcm10 regulates DNA replication elongation by stimulating the CMG replicative helicase.Pre-initiation complex assembly functions as a molecular switch that splits the Mcm2-7 double hexamer.Cryo-EM of dynamic protein complexes in eukaryotic DNA replication.Cryo-EM structure of the replisome reveals multiple interactions coordinating DNA synthesis.Mechanisms and regulation of DNA replication initiation in eukaryotes.Structural insights into Cdc45 function: was there a nuclease at the heart of the ancestral replisome?A role for the base excision repair enzyme NEIL3 in replication-dependent repair of interstrand DNA cross-links derived from psoralen and abasic sites.Eukaryotic DNA Replication Fork.From structure to mechanism-understanding initiation of DNA replication.Structural basis of Mcm2-7 replicative helicase loading by ORC-Cdc6 and Cdt1.Arranging eukaryotic nuclear DNA polymerases for replication: Specific interactions with accessory proteins arrange Pols α, δ, and ϵ in the replisome for leading-strand and lagging-strand DNA replication.Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104.Two Archaeal RecJ Nucleases from Methanocaldococcus jannaschii Show Reverse Hydrolysis Polarity: Implication to Their Unique Function in Archaea.Ufd1-Npl4 Recruit Cdc48 for Disassembly of Ubiquitylated CMG Helicase at the End of Chromosome Replication.Action of CMG with strand-specific DNA blocks supports an internal unwinding mode for the eukaryotic replicative helicase.Cryo-EM structure of Mcm2-7 double hexamer on DNA suggests a lagging-strand DNA extrusion model.The Cdc45/RecJ-like protein forms a complex with GINS and MCM, and is important for DNA replication in Thermococcus kodakarensis.Cryo-EM structure of a licensed DNA replication origin.Possible function of the second RecJ-like protein in stalled replication fork repair by interacting with Hef.Noise in the Machine: Alternative Pathway Sampling is the Rule During DNA Replication.The ring-shaped hexameric helicases that function at DNA replication forks.The crystal structure of Pyrococcus furiosus RecJ implicates it as an ancestor of eukaryotic Cdc45.The Eukaryotic CMG Helicase at the Replication Fork: Emerging Architecture Reveals an Unexpected Mechanism.Architecture of the Saccharomyces cerevisiae Replisome.Open-ringed structure of the Cdt1-Mcm2-7 complex as a precursor of the MCM double hexamer.An MCM4 mutation detected in cancer cells affects MCM4/6/7 complex formation.The Human Replicative Helicase, the CMG Complex, as a Target for Anti-cancer Therapy.Crystal Structure of Cdc45 Suggests a Conformational Switch that May Regulate DNA ReplicationBacterial and Eukaryotic Replisome Machines
P2860
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P2860
Cryo-EM structures of the eukaryotic replicative helicase bound to a translocation substrate.
description
2016 nî lūn-bûn
@nan
2016 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
Cryo-EM structures of the euka ...... d to a translocation substrate
@nl
Cryo-EM structures of the euka ...... to a translocation substrate.
@ast
Cryo-EM structures of the euka ...... to a translocation substrate.
@en
type
label
Cryo-EM structures of the euka ...... d to a translocation substrate
@nl
Cryo-EM structures of the euka ...... to a translocation substrate.
@ast
Cryo-EM structures of the euka ...... to a translocation substrate.
@en
prefLabel
Cryo-EM structures of the euka ...... d to a translocation substrate
@nl
Cryo-EM structures of the euka ...... to a translocation substrate.
@ast
Cryo-EM structures of the euka ...... to a translocation substrate.
@en
P2093
P2860
P50
P3181
P356
P1476
Cryo-EM structures of the euka ...... to a translocation substrate.
@en
P2093
Alessandro Costa
Ferdos Abid Ali
Hailey L Gahlon
Jin Chuan Zhou
Julian Gannon
P2860
P2888
P3181
P356
10.1038/NCOMMS10708
P407
P577
2016-02-18T00:00:00Z
P5875
P6179
1024121020