Structure-based design guides the improved efficacy of deacylation transition state analogue inhibitors of TEM-1 beta-Lactamase(,)
about
Structure-based optimization of cephalothin-analogue boronic acids as β-lactamase inhibitorsNovel Insights into the Mode of Inhibition of Class A SHV-1 -Lactamases Revealed by Boronic Acid Transition State InhibitorsTargeting Class A and C Serine β-Lactamases with a Broad-Spectrum Boronic Acid DerivativeTargeting Antibiotic ResistanceDetection of Escherichia coli and associated β-lactamases genes from diabetic foot ulcers by multiplex PCR and molecular modeling and docking of SHV-1, TEM-1, and OXA-1 β-lactamases with clindamycin and piperacillin-tazobactamDefying the activity-stability trade-off in enzymes: taking advantage of entropy to enhance activity and thermostability.Kinetics and mechanism of inhibition of a serine beta-lactamase by O-aryloxycarbonyl hydroxamatesOvercoming antimicrobial resistance by targeting resistance mechanisms.Structure, function, and inhibition along the reaction coordinate of CTX-M beta-lactamases.Interaction of zwitterionic penicillins with the OmpF channel facilitates their translocation.The bacterial cell wall as a source of antibacterial targets.Click Chemistry in Lead Optimization of Boronic Acids as β-Lactamase Inhibitors.Boronic Acid Transition State Inhibitors Active against KPC and Other Class A β-Lactamases: Structure-Activity Relationships as a Guide to Inhibitor DesignTrans-resveratrol boronic acid exhibits enhanced anti-proliferative activity on estrogen-dependent MCF-7 breast cancer cellsCyclic Boronates Inhibit All Classes of β-Lactamases.Aminoboronic acids and esters: from synthetic challenges to the discovery of unique classes of enzyme inhibitors.β-Lactamase inhibitors: a review of the patent literature (2010 - 2013).Recent Advances in the Rational Design and Optimization of Antibacterial Agents.Exploring the potential of boronic acids as inhibitors of OXA-24/40 β-lactamase.Homology modeling and virtual screening of inhibitors against TEM- and SHV-type-resistant mutants: A multilayer filtering approach.Rational design of a beta-lactamase inhibitor achieved via stabilization of the trans-enamine intermediate: 1.28 A crystal structure of wt SHV-1 complex with a penam sulfoneInteractions of "bora-penicilloates" with serine β-lactamases and DD-peptidasesSite-saturation mutagenesis of Tyr-105 reveals its importance in substrate stabilization and discrimination in TEM-1 beta-lactamase.Predicting Displaceable Water Sites Using Mixed-Solvent Molecular Dynamics.Crystallographic Snapshots of Class A β-Lactamase Catalysis Reveal Structural Changes That Facilitate β-Lactam Hydrolysis.
P2860
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P2860
Structure-based design guides the improved efficacy of deacylation transition state analogue inhibitors of TEM-1 beta-Lactamase(,)
description
2000 nî lūn-bûn
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2000 թուականի Մայիսին հրատարակուած գիտական յօդուած
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2000 թվականի մայիսին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Structure-based design guides ...... ors of TEM-1 beta-Lactamase(,)
@ast
Structure-based design guides ...... ors of TEM-1 beta-Lactamase(,)
@en
Structure-based design guides ...... ors of TEM-1 beta-Lactamase(,)
@nl
type
label
Structure-based design guides ...... ors of TEM-1 beta-Lactamase(,)
@ast
Structure-based design guides ...... ors of TEM-1 beta-Lactamase(,)
@en
Structure-based design guides ...... ors of TEM-1 beta-Lactamase(,)
@nl
prefLabel
Structure-based design guides ...... ors of TEM-1 beta-Lactamase(,)
@ast
Structure-based design guides ...... ors of TEM-1 beta-Lactamase(,)
@en
Structure-based design guides ...... ors of TEM-1 beta-Lactamase(,)
@nl
P2093
P3181
P356
P1433
P1476
Structure-based design guides ...... ors of TEM-1 beta-Lactamase(,)
@en
P2093
A M Kindler
N C Strynadka
S E Jensen
P304
P3181
P356
10.1021/BI992505B
P407
P577
2000-05-09T00:00:00Z