X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch - Wikidata - wikimedia - TriplyDB

X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch

X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch

http://www.wikidata.org/entity/Q27641169

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Identification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptor Structural mechanism for sterol sensing and transport by OSBP-related proteins.PPARgamma1 and LXRalpha face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1 Crystal structure of the PXR–T1317 complex provides a scaffold to examine the potential for receptor antagonism Structural Basis of Digoxin That Antagonizes ROR t Receptor Activity and Suppresses Th17 Cell Differentiation and Interleukin (IL)-17 Production Structural Conservation of Ligand Binding Reveals a Bile Acid-like Signaling Pathway in Nematodes Structural basis for a molecular allosteric control mechanism of cofactor binding to nuclear receptors Structure of the S. aureus PI-Specific Phospholipase C Reveals Modulation of Active Site Access by a Titratable π-Cation Latched Loop Liver X receptors at the intersection of lipid metabolism and atherogenesis Retinoic acid actions through mammalian nuclear receptors.Structural overview of the nuclear receptor superfamily: insights into physiology and therapeutics.Liver LXRα expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice Nuclear receptors as drug targets for metabolic disease.Nuclear receptor engineering based on novel structure activity relationships revealed by farnesyl pyrophosphate.Identification of novel liver X receptor activators by structure-based modeling Structural and functional insights into nuclear receptor signaling.The X-ray structure of a hemipteran ecdysone receptor ligand-binding domain: comparison with a lepidopteran ecdysone receptor ligand-binding domain and implications for insecticide design.A functionally orthogonal ligand-receptor pair created by targeting the allosteric mechanism of the thyroid hormone receptor.Evolution of promiscuous nuclear hormone receptors: LXR, FXR, VDR, PXR, and CAR 2D IR spectroscopy of histidine: probing side-chain structure and dynamics via backbone amide vibrations.The influence of ligand-activated LXR on primary human trophoblasts.Oxysterol binding proteins: in more than one place at one time?Evidence that His349 acts as a pH-inducible switch to accelerate receptor-mediated iron release from the C-lobe of human transferrin.Ligands of Therapeutic Utility for the Liver X Receptors.Hyodeoxycholic acid derivatives as liver X receptor α and G-protein-coupled bile acid receptor agonists.Human PXR forms a tryptophan zipper-mediated homodimer Ligand specificity and evolution of liver X receptors.Antiatherosclerotic effects of a novel synthetic tissue-selective steroidal liver X receptor agonist in low-density lipoprotein receptor-deficient mice.Selective partial agonism of liver X receptor alpha is related to differential corepressor recruitment Understanding nuclear receptor form and function using structural biology Liver X receptor modulators: a review of recently patented compounds (2007 - 2009).Orphan nuclear receptors as targets for drug development.Identifying and characterizing promiscuous targets: implications for virtual screening.Biological roles of liver X receptors in immune cells.Hypercholesterolemia links hematopoiesis with atherosclerosis.LXR, prostate cancer and cholesterol: the Good, the Bad and the Ugly.Incorporating protein flexibility into docking and structure-based drug design.A novel principle for partial agonism of liver X receptor ligands. Competitive recruitment of activators and repressors.The oxysterol receptors LXRα and LXRβ suppress proliferation in the colon.Nuclear receptor liver X receptor is O-GlcNAc-modified in response to glucose.

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P2860

X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch

http://www.wikidata.org/entity/Q27641169

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2003 nî lūn-bûn

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2003 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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X-ray crystal structure of the ...... a histidine-tryptophan switch

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X-ray crystal structure of the ...... a histidine-tryptophan switch

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X-ray crystal structure of the ...... a histidine-tryptophan switch

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X-ray crystal structure of the ...... a histidine-tryptophan switch

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X-ray crystal structure of the ...... a histidine-tryptophan switch

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Journal of Biological Chemistry

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X-ray crystal structure of the ...... a histidine-tryptophan switch

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Ann B Miller

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Bruce Wisely

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David D McKee

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Derek Parks

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Jason Nichols

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Jon L Collins

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Linda Moore

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Mike Watson

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Millard H Lambert

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P2860

Molecular recognition of fatty acids by peroxisome proliferator-activated receptors

The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand

Role of LXRs in control of lipogenesis

Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway

Synthetic LXR ligand inhibits the development of atherosclerosis in mice

Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta

Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha

Processing of X-ray diffraction data collected in oscillation mode

The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

X-ray structure of the hRORalpha LBD at 1.63 A: structural and functional data that cholesterol or a cholesterol derivative is the natural ligand of RORalpha

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27138-43

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10.1074/JBC.M302260200

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29

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278

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X-ray crystallography

crystal structure