Molecular dynamics using atomic-resolution structure reveal structural fluctuations that may lead to polymerization of human Cu Zn superoxide dismutase
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Structures of the G85R variant of SOD1 in familial amyotrophic lateral sclerosisStructural Characterization of Zinc-deficient Human Superoxide Dismutase and Implications for ALSPurification and crystallization of human Cu/Zn superoxide dismutase recombinantly produced in the protozoanLeishmania tarentolaeCrystal structure of Cu / Zn superoxide dismutase from Taenia solium reveals metal-mediated self-assemblyStructural and thermodynamic effects of post-translational modifications in mutant and wild type Cu, Zn superoxide dismutase.Lipid-associated aggregate formation of superoxide dismutase-1 is initiated by membrane-targeting loops.Copper-based pulsed dipolar ESR spectroscopy as a probe of protein conformation linked to disease states.Aggregation propensities of superoxide dismutase G93 hotspot mutants mirror ALS clinical phenotypesThe structural biochemistry of the superoxide dismutases.Thermal fluctuations of immature SOD1 lead to separate folding and misfolding pathways.Selective association of misfolded ALS-linked mutant SOD1 with the cytoplasmic face of mitochondria.Early steps in thermal unfolding of superoxide dismutase 1 are similar to the conformational changes associated with the ALS-associated A4V mutation.Dynamical roles of metal ions and the disulfide bond in Cu, Zn superoxide dismutase folding and aggregation.Structural changes to monomeric CuZn superoxide dismutase caused by the familial amyotrophic lateral sclerosis-associated mutation A4V.Metal deficiency increases aberrant hydrophobicity of mutant superoxide dismutases that cause amyotrophic lateral sclerosisMisfolded SOD1 and ALS: zeroing in on mitochondria.An emerging role for misfolded wild-type SOD1 in sporadic ALS pathogenesis.Destabilization of the dimer interface is a common consequence of diverse ALS-associated mutations in metal free SOD1Dynamic properties of SOD1 mutants can predict survival time of patients carrying familial amyotrophic lateral sclerosis.The structural plasticity of the human copper chaperone for SOD1: insights from combined size-exclusion chromatographic and solution X-ray scattering studies.Is the spinal cord motoneuron exclusively a target in ALS? Comparison between astroglial reactivity in a rat model of familial ALS and in human sporadic ALS cases.Many roads lead to Rome? Multiple modes of Cu,Zn superoxide dismutase destabilization, misfolding and aggregation in amyotrophic lateral sclerosis.Confirmation of the severe phenotypic effect of serine at codon 41 of the superoxide dismutase 1 gene.Molecular mechanisms underlying the impact of mutations in SOD1 on its conformational properties associated with amyotrophic lateral sclerosis as revealed with molecular modelling.A structural modeling approach for the understanding of initiation and elongation of ALS-linked superoxide dismutase fibrils.Study of mutation and misfolding of Cu-Zn SOD1 protein.Misfolded SOD1 pathology in sporadic Amyotrophic Lateral Sclerosis
P2860
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P2860
Molecular dynamics using atomic-resolution structure reveal structural fluctuations that may lead to polymerization of human Cu Zn superoxide dismutase
description
2007 nî lūn-bûn
@nan
2007 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Molecular dynamics using atomi ...... man Cu Zn superoxide dismutase
@ast
Molecular dynamics using atomi ...... man Cu Zn superoxide dismutase
@en
Molecular dynamics using atomi ...... man Cu Zn superoxide dismutase
@nl
type
label
Molecular dynamics using atomi ...... man Cu Zn superoxide dismutase
@ast
Molecular dynamics using atomi ...... man Cu Zn superoxide dismutase
@en
Molecular dynamics using atomi ...... man Cu Zn superoxide dismutase
@nl
prefLabel
Molecular dynamics using atomi ...... man Cu Zn superoxide dismutase
@ast
Molecular dynamics using atomi ...... man Cu Zn superoxide dismutase
@en
Molecular dynamics using atomi ...... man Cu Zn superoxide dismutase
@nl
P2093
P2860
P356
P1476
Molecular dynamics using atomi ...... man Cu Zn superoxide dismutase
@en
P2093
Chin W Yong
Richard W Strange
S Samar Hasnain
William Smith
P2860
P304
P356
10.1073/PNAS.0703857104
P407
P577
2007-06-12T00:00:00Z