Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines - Wikidata - wikimedia - TriplyDB

Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines

Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines

http://www.wikidata.org/entity/Q27674753

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Insights into cytokine-receptor interactions from cytokine engineering Receptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signaling Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency Cytokine Activation by Antibody Fragments Targeted to Cytokine-Receptor Signaling Complexes.A molecular perspective on TH2-promoting cytokine receptors in patients with allergic disease.Extraordinary effects of unnatural pairings IL4 receptor ILR4α regulates metastatic colonization by mammary tumors through multiple signaling pathways IL-4 abrogates T(H)17 cell-mediated inflammation by selective silencing of IL-23 in antigen-presenting cells IL4 receptor α mediates enhanced glucose and glutamine metabolism to support breast cancer growth."Velcro" engineering of high affinity CD47 ectodomain as signal regulatory protein α (SIRPα) antagonists that enhance antibody-dependent cellular phagocytosis Targeting IL4/IL4R for the treatment of epithelial cancer metastasis.Binding of interferon reduces the force of unfolding for interferon receptor 1.Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers.Multifarious determinants of cytokine receptor signaling specificity.Ligand-inducible dimeric antibody for selecting antibodies against a membrane protein based on mammalian cell proliferation.Reprogramming cellular functions with engineered membrane proteins.Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments.Induced conformational change in human IL-4 upon binding of a signal-neutralizing DARPin.Commentary: IL-4 and IL-13 receptors and signaling Lessons from immunology: IL4R directly promotes mammary tumor metastasis.IL-1 Family Cytokines Use Distinct Molecular Mechanisms to Signal through Their Shared Co-receptor.Gathering support for critical mass: interleukin 4 receptor signaling requires clustering in endosomes.Pressuromodulation at the cell membrane as the basis for small molecule hormone and peptide regulation of cellular and nuclear function [Superkines: cytokines displaying better targeted functions].IL-4 and IL-13 Receptor Signaling From 4PS to Insulin Receptor Substrate 2: There and Back Again, a Historical View.Tuning the Cytokine Responses: An Update on Interleukin (IL)-4 and IL-13 Receptor Complexes.Mapping Determinants of Cytokine Signaling via Protein Engineering Regulation of Energy Expenditure and Brown/Beige Thermogenic Activity by Interleukins: New Roles for Old Actors

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Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines

http://www.wikidata.org/entity/Q27674753

description

2012 nî lūn-bûn

@nan

2012 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2012年の論文

@ja

2012年論文

@yue

2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu

name

Redirecting cell-type specific ...... eered interleukin-4 superkines

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Redirecting cell-type specific ...... eered interleukin-4 superkines

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Redirecting cell-type specific ...... eered interleukin-4 superkines

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type

label

Redirecting cell-type specific ...... eered interleukin-4 superkines

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Redirecting cell-type specific ...... eered interleukin-4 superkines

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Redirecting cell-type specific ...... eered interleukin-4 superkines

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prefLabel

Redirecting cell-type specific ...... eered interleukin-4 superkines

@ast

Redirecting cell-type specific ...... eered interleukin-4 superkines

@en

Redirecting cell-type specific ...... eered interleukin-4 superkines

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Nature Chemical Biology

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Redirecting cell-type specific ...... eered interleukin-4 superkines

@en

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C Garrison Fathman

http://www.w3.org/2001/XMLSchema#string

Darren L Bates

http://www.w3.org/2001/XMLSchema#string

Edgar G Engleman

http://www.w3.org/2001/XMLSchema#string

Ignacio Moraga

http://www.w3.org/2001/XMLSchema#string

Ilkka S Junttila

http://www.w3.org/2001/XMLSchema#string

K Christopher Garcia

http://www.w3.org/2001/XMLSchema#string

Martin Meier-Schellersheim

http://www.w3.org/2001/XMLSchema#string

Megan M Suhoski

http://www.w3.org/2001/XMLSchema#string

Michael N Alonso

http://www.w3.org/2001/XMLSchema#string

Michael T Wong

http://www.w3.org/2001/XMLSchema#string

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Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface

Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system

Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'

The IL-4 receptor: signaling mechanisms and biologic functions

Kinetic analysis of the interleukin-13 receptor complex

Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule

Fluorescent cell barcoding in flow cytometry allows high-throughput drug screening and signaling profiling.

A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor.

A short pulse of IL-4 delivered by DCs electroporated with modified mRNA can both prevent and treat autoimmune diabetes in NOD mice.

Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells

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990-8

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scholarly article

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10.1038/NCHEMBIO.1096

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12

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8

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2012-12-01T00:00:00Z

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232720429

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1034187195

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23103943

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3508151

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