Species-specific detection of the antiviral small-molecule compound CMA by STING - Wikidata - wikimedia - TriplyDB

Species-specific detection of the antiviral small-molecule compound CMA by STING

Species-specific detection of the antiviral small-molecule compound CMA by STING

http://www.wikidata.org/entity/Q27677466

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Single nucleotide polymorphisms of human STING can affect innate immune response to cyclic dinucleotides DNA vaccines: a simple DNA sensing matter?Structural mechanism of cytosolic DNA sensing by cGAS Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA International Union of Basic and Clinical Pharmacology. XCVI. Pattern recognition receptors in health and disease Rat and human STINGs profile similarly towards anticancer/antiviral compounds Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses Involvement of GATA1 and Sp3 in the activation of the murine STING gene promoter in NIH3T3 cells.Identification of a small molecule that primes the type I interferon response to cytosolic DNA.cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.Listeria monocytogenes induces IFNβ expression through an IFI16-, cGAS- and STING-dependent pathway.Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.The DNA sensor, cyclic GMP-AMP synthase, is essential for induction of IFN-β during Chlamydia trachomatis infection.The mechanism of double-stranded DNA sensing through the cGAS-STING pathway STING agonists induce an innate antiviral immune response against hepatitis B virus.Structural biology of innate immunity.The mucosal adjuvant cyclic di-GMP enhances antigen uptake and selectively activates pinocytosis-efficient cells in vivo.Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity.The cGAS-STING pathway for DNA sensing.Anticancer flavonoids are mouse-selective STING agonists.STING, nanoparticles, autoimmune disease and cancer: a novel paradigm for immunotherapy?Microbial DNA recognition by cGAS-STING and other sensors in dendritic cells in inflammatory bowel diseases.Cytosolic sensing of aberrant DNA: arming STING on the endoplasmic reticulum.The emerging roles of the STING adaptor protein in immunity and diseases.Amplification of N-Myc is associated with a T-cell-poor microenvironment in metastatic neuroblastoma restraining interferon pathway activity and chemokine expression.Activation of cGAS-dependent antiviral responses by DNA intercalating agents.Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells.STING contributes to antiglioma immunity via triggering type I IFN signals in the tumor microenvironment.Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing.Posttranslational Modification as a Critical Determinant of Cytoplasmic Innate Immune Recognition.Cyclic Dinucleotides in the Scope of the Mammalian Immune System.AMP-activated Kinase (AMPK) Promotes Innate Immunity and Antiviral Defense through Modulation of Stimulator of Interferon Genes (STING) Signaling.[Stimulating Type I interferon response with small molecules: revival of an old idea].Signalling strength determines proapoptotic functions of STING.A cell-based high throughput screening assay for the discovery of cGAS-STING pathway agonists.The Q Motif Is Involved in DNA Binding but Not ATP Binding in ChlR1 Helicase.STING mediated induction of host immune responses Modeling Primary Human Monocytes with the Trans-Differentiation Cell Line BLaER1.Activation of the STING-Dependent Type I Interferon Response Reduces Microglial Reactivity and Neuroinflammation.Emerging Alphaviruses are Sensitive to Cellular States Induced by a Novel Small Molecule Agonist of the STING Pathway.

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Species-specific detection of the antiviral small-molecule compound CMA by STING

http://www.wikidata.org/entity/Q27677466

description

2013 nî lūn-bûn

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2013 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2013 թվականի մայիսին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

Species-specific detection of the antiviral small-molecule compound CMA by STING

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Species-specific detection of the antiviral small-molecule compound CMA by STING

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Species-specific detection of the antiviral small-molecule compound CMA by STING

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type

label

Species-specific detection of the antiviral small-molecule compound CMA by STING

@ast

Species-specific detection of the antiviral small-molecule compound CMA by STING

@en

Species-specific detection of the antiviral small-molecule compound CMA by STING

@nl

prefLabel

Species-specific detection of the antiviral small-molecule compound CMA by STING

@ast

Species-specific detection of the antiviral small-molecule compound CMA by STING

@en

Species-specific detection of the antiviral small-molecule compound CMA by STING

@nl

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The EMBO Journal

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Species-specific detection of the antiviral small-molecule compound CMA by STING

@en

P2093

Andrea Ablasser

http://www.w3.org/2001/XMLSchema#string

Taner Cavlar

http://www.w3.org/2001/XMLSchema#string

Tobias Deimling

http://www.w3.org/2001/XMLSchema#string

P2860

Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway

ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

Cyclic di-GMP sensing via the innate immune signaling protein STING

c-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon response

Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system

STING is a direct innate immune sensor of cyclic di-GMP

A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP

PHENIX: a comprehensive Python-based system for macromolecular structure solution

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1440-50

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scholarly article

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10.1038/EMBOJ.2013.86

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10

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32

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Karl-Peter Hopfner

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2013-05-15T00:00:00Z

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236252720

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23604073

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3655471

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