Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation - Wikidata - wikimedia - TriplyDB

Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation

Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation

http://www.wikidata.org/entity/Q27677515

about

Impact of Chromatin on HIV Replication Multifunctional facets of retrovirus integrase HIV-1 capsid: the multifaceted key player in HIV-1 infection Blind prediction of HIV integrase binding from the SAMPL4 challenge Distribution and Redistribution of HIV-1 Nucleocapsid Protein in Immature, Mature, and Integrase-Inhibited Virions: a Role for Integrase in Maturation Allosteric Inhibition of Human Immunodeficiency Virus Integrase Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage.A new class of multimerization selective inhibitors of HIV-1 integrase Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1 A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain The Preserved HTH-Docking Cleft of HIV-1 Integrase Is Functionally Critical Retroviral Integrase: Then and Now Non-catalytic site HIV-1 integrase inhibitors disrupt core maturation and induce a reverse transcription block in target cells Engineered hyperactive integrase for concerted HIV-1 DNA integration Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase Retroviral DNA Integration In vitro protease cleavage and computer simulations reveal the HIV-1 capsid maturation pathway.Preclinical profile of BI 224436, a novel HIV-1 non-catalytic-site integrase inhibitor Rous sarcoma virus synaptic complex capable of concerted integration is kinetically trapped by human immunodeficiency virus integrase strand transfer inhibitors.Virtual screening of integrase inhibitors by large scale binding free energy calculations: the SAMPL4 challenge.A critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase.The N-terminus of murine leukaemia virus p12 protein is required for mature core stability.The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase.HIV-1 IN/Pol recruits LEDGF/p75 into viral particles The allosteric HIV-1 integrase inhibitor BI-D affects virion maturation but does not influence packaging of a functional RNA genome Retroviral DNA Transposition: Themes and Variations HIV-1 Gag as an Antiviral Target: Development of Assembly and Maturation Inhibitors.Host Factors in Retroviral Integration and the Selection of Integration Target Sites.A critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin.Methods for the Analyses of Inhibitor-Induced Aberrant Multimerization of HIV-1 Integrase.Integrating the HIV-1 assembly/maturation pathway.Allosteric inhibition of HIV-1 integrase activity.The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency.LEDGIN-mediated Inhibition of Integrase-LEDGF/p75 Interaction Reduces Reactivation of Residual Latent HIV An Essential Role of INI1/hSNF5 Chromatin Remodeling Protein in HIV-1 Posttranscriptional Events and Gag/Gag-Pol Stability.Quantitative evaluation of the antiretroviral efficacy of dolutegravir.Critical Contribution of Tyr15 in the HIV-1 Integrase (IN) in Facilitating IN Assembly and Nonenzymatic Function through the IN Precursor Form with Reverse Transcriptase.Multimodal mechanism of action of allosteric HIV-1 integrase inhibitors.Computational and synthetic approaches for developing Lavendustin B derivatives as allosteric inhibitors of HIV-1 integrase LEDGINs, non-catalytic site inhibitors of HIV-1 integrase: a patent review (2006 - 2014).

P2860

Q26782046-C1E232D4-E954-453A-84B5-6ACAB73E4241 Q26795766-660DF66F-3C16-4A2B-A449-1FB1E6C1AB9A Q26801145-3321227F-488A-43F8-8085-3875C0D06D23 Q26864619-AC0D4C3D-DB0E-49E4-933D-0FC82609933A Q27321347-0BA7D0FC-DB3D-4867-89E3-FBF2F610AD26 Q27644578-329E8715-0DDF-4660-A3ED-A5256FDD1D49 Q27680666-F11C1D75-2E56-4C49-ADD2-9B8E29D2D828 Q27683994-A86A37F9-494B-4DDF-A39E-E4C0F81E8E1A Q27684242-53BDD6B1-0EAB-4C18-AF7E-AA04E76EA550 Q27728086-E5F8400E-35AA-4571-84BE-F473F814B131 Q27728153-F05A04D0-0847-44ED-859F-F1540D29B6CA Q28073156-47E3C08B-836C-4458-8F12-027B5A65C3EB Q28536951-4A441DC4-DA10-4217-BCA7-6720986A120D Q28541856-ECDF3311-9394-4F7B-9C2C-66D5802879AF Q28554866-34A72624-D4DD-4454-923E-2182A1B7F505 Q28596842-5D1A49F2-B559-4CD6-8082-2CD960DC925B Q30832180-AF9A1654-7200-4C5A-A3D0-E88F4AD059F2 Q33797858-6AB487B0-CCC0-4EEC-BF5E-4E2058841416 Q33888602-52E4C9F3-FE45-4CF2-854A-26F9F03EE7CC Q34065423-ACFB04B6-D4B6-4CA4-8727-6627A69FA83F Q34249167-E3E3FC06-0316-4899-A158-605ADBD97317 Q34428741-1F0F49DF-DDD8-43E6-B7EB-9B6DF1FD4081 Q34611548-891035A4-6BD5-4E21-9C74-57ACDA48D5D5 Q35170009-CD1FB7FB-663F-4EF6-8DE9-568346A008FD Q35215018-EF4795FF-6CC6-478C-A2CF-734D6A04E377 Q35249277-20D49E4F-0532-4372-953E-09C825E70667 Q35761626-610348D7-A891-4227-A657-503CFAC1E680 Q35916677-2B3398E4-E31D-4C09-89C3-EB2DAB0698ED Q36646385-859DAEAD-02C7-4CC1-AE2F-27C686736999 Q36691836-F0371CCB-7506-414B-92F4-230F2C667467 Q36884128-CD3EF2FA-0D36-4E75-A1E4-45DB34B3B8E8 Q36920004-03D1202C-DD6C-47F1-931D-0467BED431FC Q36922166-C526C655-C4BA-4259-97BA-8B1C9FE47FF3 Q37035177-2C6C52A0-6A2B-4749-B712-E61AB41B43CC Q37347358-D516FC67-710E-47CA-9B2D-19F706743D66 Q37417514-6869DEF2-19C3-48B5-B142-B58194B374A2 Q37512925-CE0D98C1-11A3-426C-89EC-0C1B12F26F81 Q37574479-88059F91-6688-4E63-8E97-70BE17DA6597 Q37616219-85649807-9B89-4462-95D8-A71B37433C4D Q38199193-A03F7B03-82D5-4A01-B051-47739FB111B2

P2860

Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation

http://www.wikidata.org/entity/Q27677515

description

2013 nî lūn-bûn

@nan

2013 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի մայիսին հրատարակված գիտական հոդված

@hy

2013年の論文

@ja

2013年論文

@yue

2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

name

Allosteric integrase inhibitor ...... n of HIV-1 particle maturation

@ast

Allosteric integrase inhibitor ...... n of HIV-1 particle maturation

@en

Allosteric integrase inhibitor ...... n of HIV-1 particle maturation

@nl

type

label

Allosteric integrase inhibitor ...... n of HIV-1 particle maturation

@ast

Allosteric integrase inhibitor ...... n of HIV-1 particle maturation

@en

Allosteric integrase inhibitor ...... n of HIV-1 particle maturation

@nl

prefLabel

Allosteric integrase inhibitor ...... n of HIV-1 particle maturation

@ast

Allosteric integrase inhibitor ...... n of HIV-1 particle maturation

@en

Allosteric integrase inhibitor ...... n of HIV-1 particle maturation

@nl

P1433

Q27677515-4727E1FA-42BF-473E-9C06-F810B4A0C96D

P1476

Q27677515-0E137B4C-28DA-48A1-BE79-A44351E18BAF

P2093

Q27677515-02DE73C7-0362-4A25-8A5F-5A810AE4A7E7

Q27677515-05C88104-0322-499E-801F-A41D7CEE0522

Q27677515-334F7C2E-3A57-41DC-A9D7-A65A94EB4B67

Q27677515-3D5491C8-66E1-410A-A890-3E7C70C07398

Q27677515-44BDDEAD-40BE-4DF8-AFA3-AFC8D7C5C65E

Q27677515-56F0DD7E-59EC-42B6-87B5-F5F9F2563778

Q27677515-72DE078D-BE7E-40CC-B0E1-23F5DB7735A4

Q27677515-AE02CFE7-020A-489D-B7C0-BE3F5515CF28

Q27677515-CAC953AB-AFF9-48DB-A7DA-8AF2CAE1DA90

Q27677515-CB1DA4F3-6520-4B72-BBCB-90F99F05FAC1

P2860

Q27677515-02123230-F93A-47D4-902B-A1D21732CB75

Q27677515-03E4DBE2-829E-45D4-AECF-666EE9F8ABA3

Q27677515-04B006B5-E56E-4AC2-9257-E43F57483A41

Q27677515-09014881-9FC6-49BA-9FFF-33CDB21C834B

Q27677515-0BA4CD80-0977-4F9E-A0F8-7ED4ADD42078

Q27677515-10BC803A-7665-4511-923B-BFC43BEA3579

Q27677515-167D7EC6-1ABC-437C-A382-E5D2A3588476

Q27677515-171859E8-8409-4663-AF6B-701611C2CE98

Q27677515-1C7FD0D7-6FED-4257-BF99-5A3EB2E75127

Q27677515-24844F43-4E7A-4227-B9DE-D3B80F3E2BDC

P304

Q27677515-B474B7D2-6BB4-4A4A-901B-636D7A3349EC

P31

Q27677515-B015E5E1-553B-4389-90AB-BE3DAB68F565

P3181

Q27677515-DF437783-1994-47CD-879D-8225C3365810

P356

Q27677515-2A52AF52-EB53-4853-A408-DF68287D5DE0

P407

Q27677515-67C2505F-8753-444F-A527-2E83C1713C45

P433

Q27677515-952B3BBB-4FBA-486E-B99E-903904A9C080

P478

Q27677515-427CF12E-0A32-4172-9182-1AE30898AC10

P50

Q27677515-90E3800B-84BC-44FA-AF1F-473E577F23FA

P577

Q27677515-08A2D719-3CB7-414A-A24D-C29F039A7D56

P5875

Q27677515-40A03BC5-830A-47AC-8F78-4A2C54DD348E

P698

Q27677515-3A2D1F87-78FF-47A6-8688-7472811AF99C

P921

Q27677515-267EAE28-3BC2-4158-B24E-5930BB2A5D17

P932

Q27677515-2AA394AB-7530-43BD-B586-71D1093DFE70

P3181

P356

PNAS.1300703110

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Allosteric integrase inhibitor ...... n of HIV-1 particle maturation

@en

P2093

Alan Engelman

http://www.w3.org/2001/XMLSchema#string

Alison Slaughter

http://www.w3.org/2001/XMLSchema#string

Allison Ballandras-Colas

http://www.w3.org/2001/XMLSchema#string

Hao Wang

http://www.w3.org/2001/XMLSchema#string

Jacques J Kessl

http://www.w3.org/2001/XMLSchema#string

James R Fuchs

http://www.w3.org/2001/XMLSchema#string

Kellie A Jurado

http://www.w3.org/2001/XMLSchema#string

Lei Feng

http://www.w3.org/2001/XMLSchema#string

Pratiq A Patel

http://www.w3.org/2001/XMLSchema#string

Weifeng Wang

http://www.w3.org/2001/XMLSchema#string

P2860

LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes

Retroviral intasome assembly and inhibition of DNA strand transfer

Novel therapeutic strategies targeting HIV integrase

Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication

Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

New Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of Action

Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases

Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase

Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells

Potent nonnucleoside reverse transcriptase inhibitors target HIV-1 Gag-Pol

P304

8690-5

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

1636982

http://www.w3.org/2001/XMLSchema#string

P356

10.1073/PNAS.1300703110

http://www.w3.org/2001/XMLSchema#string

P407

P433

21

http://www.w3.org/2001/XMLSchema#string

P478

110

http://www.w3.org/2001/XMLSchema#string

P50

Mamuka Kvaratskhelia

P577

2013-05-21T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

236267318

http://www.w3.org/2001/XMLSchema#string

P698

23610442

http://www.w3.org/2001/XMLSchema#string

P921

allosteric inhibitor

P932

3666754

http://www.w3.org/2001/XMLSchema#string