Wnt-7a causes loss of differentiated phenotype and inhibits apoptosis of articular chondrocytes via different mechanisms
about
Expression of novel extracellular sulfatases Sulf-1 and Sulf-2 in normal and osteoarthritic articular cartilageWnts talking with the TGF-β superfamily: WISPers about modulation of osteoarthritisCytokine networking of chondrocyte dedifferentiation in vitro and its implications for cell-based cartilage therapyCytokine-like 1 knock-out mice (Cytl1-/-) show normal cartilage and bone development but exhibit augmented osteoarthritic cartilage destructionResveratrol protects chondrocytes from apoptosis via altering the ultrastructural and biomechanical properties: an AFM studyWnt7a Inhibits IL-1β Induced Catabolic Gene Expression and Prevents Articular Cartilage Damage in Experimental OsteoarthritisIdentification of genes regulated by Wnt/beta-catenin pathway and involved in apoptosis via microarray analysis.Altered gene expression in highly purified enterocytes from patients with active coeliac disease.Ionizing radiation induces cellular senescence of articular chondrocytes via negative regulation of SIRT1 by p38 kinase.Co-expression of DKK-1 and Sclerostin in Subchondral Bone of the Proximal Femoral Heads from Osteoarthritic HipsThe inorganic pyrophosphate transporter ANK preserves the differentiated phenotype of articular chondrocyte.WNT signaling in activated microglia is proinflammatory.Nicotinamide phosphoribosyltransferase is essential for interleukin-1beta-mediated dedifferentiation of articular chondrocytes via SIRT1 and extracellular signal-regulated kinase (ERK) complex signalingα-Catenin inhibits β-catenin-T-cell factor/lymphoid enhancing factor transcriptional activity and collagen type II expression in articular chondrocytes through formation of Gli3R.α-catenin.β-catenin ternary complex.The adaptive remodeling of condylar cartilage---a transition from chondrogenesis to osteogenesis.Inhibition of Wnt/β-catenin pathway promotes regenerative repair of cutaneous and cartilage injury.Major biological obstacles for persistent cell-based regeneration of articular cartilage.Wnt16 Signaling Is Required for IL-1β-Induced Matrix Metalloproteinase-13-Regulated Proliferation of Human Stem Cell-Derived Osteoblastic Cells.Concepts in gene therapy for cartilage repair.Coordinate integrin and c-Met signaling regulate Wnt gene expression during epithelial morphogenesis.Smurf2 induces degradation of GSK-3beta and upregulates beta-catenin in chondrocytes: a potential mechanism for Smurf2-induced degeneration of articular cartilage.Small molecule inhibitors of WNT/β-catenin signaling block IL-1β- and TNFα-induced cartilage degradation.Low-density lipoprotein receptor-related protein 5 governs Wnt-mediated osteoarthritic cartilage destruction.WNT signaling and cartilage: of mice and men.WNT signaling and chondrocytes: from cell fate determination to osteoarthritis physiopathology.Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT.Epigenetic differences in human cartilage between mild and severe OA.Effects of Wnt3A and mechanical load on cartilage chondrocyte homeostasisT cell factor 4 is a pro-catabolic and apoptotic factor in human articular chondrocytes by potentiating nuclear factor κB signaling.Inhibition of beta-catenin signaling in articular chondrocytes results in articular cartilage destruction.The association between parathyroid hormone 1‑34 and the Wnt/β‑catenin signaling pathway in a rat model of osteoarthritis.The roles of canonical and non-canonical Wnt signaling in human de-differentiated articular chondrocytes.Wnt signaling is involved in human articular chondrocyte de-differentiation in vitro.Opposing roles of WNT-5A and WNT-11 in interleukin-1beta regulation of type II collagen expression in articular chondrocytes.Regulation of beta-catenin signaling and maintenance of chondrocyte differentiation by ubiquitin-independent proteasomal degradation of alpha-catenin.The Effects of the WNT-Signaling Modulators BIO and PKF118-310 on the Chondrogenic Differentiation of Human Mesenchymal Stem Cells.BIO allieviated compressive mechanical force-mediated mandibular cartilage pathological changes through Wnt/β-catenin signaling activation.Wnt inhibitory factor 1 deficiency uncouples cartilage and bone destruction in tumor necrosis factor α-mediated experimental arthritis.Wnt-3a regulates chondrocyte differentiation via c-Jun/AP-1 pathway.Expression of pro-apoptotic markers is increased along the osteochondral junction in naturally occurring osteochondrosis.
P2860
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P2860
Wnt-7a causes loss of differentiated phenotype and inhibits apoptosis of articular chondrocytes via different mechanisms
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Wnt-7a causes loss of differen ...... cytes via different mechanisms
@ast
Wnt-7a causes loss of differen ...... cytes via different mechanisms
@en
Wnt-7a causes loss of differen ...... cytes via different mechanisms
@nl
type
label
Wnt-7a causes loss of differen ...... cytes via different mechanisms
@ast
Wnt-7a causes loss of differen ...... cytes via different mechanisms
@en
Wnt-7a causes loss of differen ...... cytes via different mechanisms
@nl
prefLabel
Wnt-7a causes loss of differen ...... cytes via different mechanisms
@ast
Wnt-7a causes loss of differen ...... cytes via different mechanisms
@en
Wnt-7a causes loss of differen ...... cytes via different mechanisms
@nl
P2093
P356
P1476
Wnt-7a causes loss of differen ...... cytes via different mechanisms
@en
P2093
Eek-Hoon Jho
Ho-Chul Jung
Il-Chul Kim
Jang-Soo Chun
Je-Hwang Ryu
Kwonseop Kim
Sang-Gu Hwang
Song-Ja Kim
P304
P356
10.1074/JBC.M401401200
P407
P577
2004-06-18T00:00:00Z