Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7
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Structure of the R3/I5 Chimeric Relaxin Peptide, a Selective GPCR135 and GPCR142 AgonistINSL5 is a high affinity specific agonist for GPCR142 (GPR100)In vitro pharmacological characterization of RXFP3 allosterism: an example of probe dependencyRelaxin-3-deficient mice showed slight alteration in anxiety-related behavior.The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptorsRelaxin-3/RXFP3 system regulates alcohol-seeking.Relaxin' the brain: a case for targeting the nucleus incertus network and relaxin-3/RXFP3 system in neuropsychiatric disorders.Development of a selective agonist for relaxin family peptide receptor 3.Signalling profiles of H3 relaxin, H2 relaxin and R3(BΔ23-27)R/I5 acting at the relaxin family peptide receptor 3 (RXFP3)Targeted chemotherapy using a cytotoxic somatostatin conjugate to inhibit tumor growth and metastasis in nude mice.International Union of Basic and Clinical Pharmacology. XCV. Recent advances in the understanding of the pharmacology and biological roles of relaxin family peptide receptors 1-4, the receptors for relaxin family peptides.The minimal active structure of human relaxin-2The structural determinants of insulin-like Peptide 3 activityRecent progress in relaxin-3-related research.Identification of key residues essential for the structural fold and receptor selectivity within the A-chain of human gene-2 (H2) relaxin.Mechanism for insulin-like peptide 5 distinguishing the homologous relaxin family peptide receptor 3 and 4Relaxin-3/RXFP3 Signaling and Neuroendocrine Function - A Perspective on Extrinsic Hypothalamic Control.Relaxin-3/RXFP3 networks: an emerging target for the treatment of depression and other neuropsychiatric diseases?Relaxin-3/insulin-like peptide 7, a neuropeptide involved in the stress response and food intake.A novel BRET-based binding assay for interaction studies of relaxin family peptide receptor 3 with its ligands.Distribution, physiology and pharmacology of relaxin-3/RXFP3 systems in brain.Relaxin-3 inputs target hippocampal interneurons and deletion of hilar relaxin-3 receptors in "floxed-RXFP3" mice impairs spatial memory.Synthesis and pharmacological characterization of a europium-labelled single-chain antagonist for binding studies of the relaxin-3 receptor RXFP3.Relaxin family peptides: structure-activity relationship studies.Secretory overexpression and isotopic labeling of the chimeric relaxin family peptide R3/I5 in Pichia pastoris.A convenient method for europium-labeling of a recombinant chimeric relaxin family peptide R3/I5 for receptor-binding assays.The highly conserved negatively charged Glu141 and Asp145 of the G-protein-coupled receptor RXFP3 interact with the highly conserved positively charged arginine residues of relaxin-3.R3(BDelta23 27)R/I5 chimeric peptide, a selective antagonist for GPCR135 and GPCR142 over relaxin receptor LGR7: in vitro and in vivo characterization.Distribution and targets of the relaxin-3 innervation of the septal area in the rat.Modulation of feeding by chronic rAAV expression of a relaxin-3 peptide agonist in rat hypothalamus.Developmental expression pattern of two zebrafish rxfp3 paralogue genes.Central relaxin-3 receptor (RXFP3) activation increases ERK phosphorylation in septal cholinergic neurons and impairs spatial working memory.Chemical synthesis and orexigenic activity of rat/mouse relaxin-3.Relaxin-3 innervation of the intergeniculate leaflet of the rat thalamus - neuronal tract-tracing and in vitro electrophysiological studies.Hypothalamic mapping of orexigenic action and Fos-like immunoreactivity following relaxin-3 administration in male Wistar rats.Expression analysis of five zebrafish RXFP3 homologues reveals evolutionary conservation of gene expression pattern.G-protein-coupled receptor (GPCR)-142 does not contribute to relaxin-3 binding in the mouse brain: further support that relaxin-3 is the physiological ligand for GPCR135.Distribution of G-protein-coupled receptor (GPCR)135 binding sites and receptor mRNA in the rat brain suggests a role for relaxin-3 in neuroendocrine and sensory processing.Orthosteric, Allosteric and Biased Signalling at the Relaxin-3 Receptor RXFP3.Rapid preparation of bioluminescent tracers for relaxin family peptides using sortase-catalysed ligation.
P2860
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P2860
Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Relaxin-3/insulin-like peptide ...... g G protein-coupled receptor 7
@ast
Relaxin-3/insulin-like peptide ...... g G protein-coupled receptor 7
@en
Relaxin-3/insulin-like peptide ...... g G protein-coupled receptor 7
@nl
type
label
Relaxin-3/insulin-like peptide ...... g G protein-coupled receptor 7
@ast
Relaxin-3/insulin-like peptide ...... g G protein-coupled receptor 7
@en
Relaxin-3/insulin-like peptide ...... g G protein-coupled receptor 7
@nl
prefLabel
Relaxin-3/insulin-like peptide ...... g G protein-coupled receptor 7
@ast
Relaxin-3/insulin-like peptide ...... g G protein-coupled receptor 7
@en
Relaxin-3/insulin-like peptide ...... g G protein-coupled receptor 7
@nl
P2093
P3181
P356
P1476
Relaxin-3/insulin-like peptide ...... g G protein-coupled receptor 7
@en
P2093
Changlu Liu
Chester Kuei
Diane Nepomuceno
Jingcai Chen
Pascal Bonaventure
Steven Sutton
Timothy W Lovenberg
P304
P3181
P356
10.1124/MOL.104.006700
P407
P577
2005-01-01T00:00:00Z