Nonnucleoside reverse transcriptase inhibitors that potently and specifically block human immunodeficiency virus type 1 replication
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Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2'-dioxide)pyrimidine (TSAO) nucleoside analogues: highlyselective inhibitors of human immunodeficiency virus type 1 that are targeted at the viral reverse transcri[2',5'-Bis-O-(tert-butyldimethylsilyl)]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide) (TSAO) derivatives of purine and pyrimidinenucleosides as potent and selective inhibitors of human immunodeficiency virus type 13'-Azido-3'-deoxythymidine resistance suppressed by a mutation conferring human immunodeficiency virus type 1 resistance to nonnucleoside reverse transcriptase inhibitorsBisheteroarylpiperazine reverse transcriptase inhibitor in combination with 3'-azido-3'-deoxythymidine or 2',3'-dideoxycytidine synergistically inhibits human immunodeficiency virus type 1 replication in vitroPreclinical evaluation of MKC-442, a highly potent and specific inhibitor of human immunodeficiency virus type 1 in vitroNew tetrahydroimidazo[4,5,1-jk][1,4]-benzodiazepin-2(1H)-one and -thione derivatives are potent inhibitors of human immunodeficiency virus type 1 replication and are synergistic with 2',3'-dideoxynucleoside analogsThe PETT series, a new class of potent nonnucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptaseAnalysis of nonnucleoside drug-resistant variants of human immunodeficiency virus type 1 reverse transcriptasePotent and highly selective human immunodeficiency virus type 1 (HIV-1) inhibition by a series of alpha-anilinophenylacetamide derivatives targeted at HIV-1 reverse transcriptaseCharacterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosidesA mutation in reverse transcriptase of bis(heteroaryl)piperazine-resistant human immunodeficiency virus type 1 that confers increased sensitivity to other nonnucleoside inhibitorsSpecific inhibition of the reverse transcriptase of human immunodeficiency virus type 1 and the chimeric enzymes of human immunodeficiency virus type 1 and type 2 by nonnucleoside inhibitorsU-90152, a potent inhibitor of human immunodeficiency virus type 1 replicationHuman immunodeficiency virus type 1 (HIV-1) strains selected for resistance against the HIV-1-specific [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro- 5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)]-beta-D-pentofurano syl (TSAO) nucleoside analoActivity of a novel quinoxaline derivative against human immunodeficiency virus type 1 reverse transcriptase and viral replicationResistance of human immunodeficiency virus type 1 to acyclic 6-phenylselenenyl- and 6-phenylthiopyrimidinesPyrido [1,2a] indole derivatives identified as novel non-nucleoside reverse transcriptase inhibitors of human immunodeficiency virus type 1Resistance of clinical isolates of human immunodeficiency virus to antiretroviral agentsCharacterization of human immunodeficiency virus type 1 strains resistant to the non-nucleoside reverse transcriptase inhibitor RD4-2217Structure-activity and cross-resistance evaluations of a series of human immunodeficiency virus type-1-specific compounds related to oxathiin carboxanilidePreclinical evaluation of HBY 097, a new nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1 replicationAntiviral activity of the dihydropyrone PNU-140690, a new nonpeptidic human immunodeficiency virus protease inhibitorIdentification of novel thiocarboxanilide derivatives that suppress a variety of drug-resistant mutant human immunodeficiency virus type 1 strains at a potency similar to that for wild-type virus1,1,3-Trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazine (TTD) derivatives: a new class of nonnucleoside human immunodeficiency virus type 1 (HIV-1) reverse transcriptase inhibitors with anti-HIV-1 activityPotent nonnucleoside reverse transcriptase inhibitors target HIV-1 Gag-PolAssociation of integrase, matrix, and reverse transcriptase antigens of human immunodeficiency virus type 1 with viral nucleic acids following acute infectionThe connection domain is implicated in metalloporphyrin binding and inhibition of HIV reverse transcriptase.Non-nucleoside reverse transcriptase inhibitors: the NNRTI boom.Human immunodeficiency virus reverse transcriptase substrate-induced conformational changes and the mechanism of inhibition by nonnucleoside inhibitors.Mutagenicity and pausing of HIV reverse transcriptase during HIV plus-strand DNA synthesisSafety, tolerance, and pharmacokinetics of atevirdine mesylate (U-87201E) in asymptomatic human immunodeficiency virus-infected patients.Mechanisms of nucleoside analog antiviral activity and resistance during human immunodeficiency virus reverse transcriptionDidanosine reduces atevirdine absorption in subjects with human immunodeficiency virus infectionsRandomized, controlled phase I/II, trial of combination therapy with delavirdine (U-90152S) and conventional nucleosides in human immunodeficiency virus type 1-infected patients.Safety, tolerance, and efficacy of atevirdine in asymptomatic human immunodeficiency virus-infected individualsSingle-dose pharmacokinetics of delavirdine mesylate and didanosine in patients with human immunodeficiency virus infection.Effect of fluconazole on the steady-state pharmacokinetics of delavirdine in human immunodeficiency virus-positive patientsDevelopment of inhibitors of reverse transcriptase and protease as therapeutics against HIV infection.
P2860
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P2860
Nonnucleoside reverse transcriptase inhibitors that potently and specifically block human immunodeficiency virus type 1 replication
description
1991 nî lūn-bûn
@nan
1991 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1991 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
name
Nonnucleoside reverse transcri ...... iency virus type 1 replication
@ast
Nonnucleoside reverse transcri ...... iency virus type 1 replication
@en
Nonnucleoside reverse transcri ...... iency virus type 1 replication
@nl
type
label
Nonnucleoside reverse transcri ...... iency virus type 1 replication
@ast
Nonnucleoside reverse transcri ...... iency virus type 1 replication
@en
Nonnucleoside reverse transcri ...... iency virus type 1 replication
@nl
prefLabel
Nonnucleoside reverse transcri ...... iency virus type 1 replication
@ast
Nonnucleoside reverse transcri ...... iency virus type 1 replication
@en
Nonnucleoside reverse transcri ...... iency virus type 1 replication
@nl
P2093
P2860
P356
P1476
Nonnucleoside reverse transcri ...... iency virus type 1 replication
@en
P2093
D L Romero
J R Palmer
K M Downey
P A Aristoff
P2860
P304
P356
10.1073/PNAS.88.19.8806
P407
P577
1991-10-01T00:00:00Z