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In vitro genotoxicity testing strategy for nanomaterials and the adaptation of current OECD guidelines

In vitro genotoxicity testing strategy for nanomaterials and the adaptation of current OECD guidelines

http://www.wikidata.org/entity/Q28386315

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How should the completeness and quality of curated nanomaterial data be evaluated?An ISA-TAB-Nano based data collection framework to support data-driven modelling of nanotoxicology Critical review of the current and future challenges associated with advanced in vitro systems towards the study of nanoparticle (secondary) genotoxicity Emerging metrology for high-throughput nanomaterial genotoxicology Undetactable levels of genotoxicity of SiO2 nanoparticles in in vitro and in vivo tests Genetic toxicity assessment of engineered nanoparticles using a 3D in vitro skin model (EpiDerm™)Mechanism-based genotoxicity screening of metal oxide nanoparticles using the ToxTracker panel of reporter cell lines Genotoxicity of metal oxide nanomaterials: review of recent data and discussion of possible mechanisms.Impact of nanosilver on various DNA lesions and HPRT gene mutations - effects of charge and surface coating Silver nanoparticles: correlating nanoparticle size and cellular uptake with genotoxicity.Mutagenic Effects of Nanosilver Consumer Products: a new Approach to Physicochemical Properties.Appropriate in vitro methods for genotoxicity testing of silver nanoparticles Assessing nanoparticle toxicity in cell-based assays: influence of cell culture parameters and optimized models for bridging the in vitro-in vivo gap.Manufactured nanomaterials: categorization and approaches to hazard assessment.From the Cover: An Investigation of the Genotoxicity and Interference of Gold Nanoparticles in Commonly Used In Vitro Mutagenicity and Genotoxicity Assays.Suitability of human and mammalian cells of different origin for the assessment of genotoxicity of metal and polymeric engineered nanoparticles.Cell type-dependent changes in CdSe/ZnS quantum dot uptake and toxic endpoints.Is the toxic potential of nanosilver dependent on its size?Genotoxic and immunotoxic effects of cellulose nanocrystals in vitro.Towards a New Paradigm in Nano-Genotoxicology: Facing Complexity of Nanomaterials' Cellular Interactions and Effects.Titanium dioxide nanoparticles: an in vitro study of DNA binding, chromosome aberration assay, and comet assay.Tracking stem cells with superparamagnetic iron oxide nanoparticles: perspectives and considerations.The use of the comet assay for the evaluation of the genotoxicity of nanomaterials.Genotoxicity of nanomaterials: refining strategies and tests for hazard identification.Safety Aspects of Bio-Based Nanomaterials.In Vivo toxicological assessment of biologically synthesized silver nanoparticles in adult Zebrafish (Danio rerio).Genotoxic and mutagenic properties of Ni and NiO nanoparticles investigated by comet assay, γ-H2AX staining, Hprt mutation assay and ToxTracker reporter cell lines.A theoretical approach for a weighted assessment of the mutagenic potential of nanomaterials.Differences in MWCNT- and SWCNT-induced DNA methylation alterations in association with the nuclear deposition.The Impact of Novel Assessment Methodologies in Toxicology on Green Chemistry and Chemical Alternatives.Carcinogenicity of multi-walled carbon nanotubes: challenging issue on hazard assessment.Influence of the surface coating on the cytotoxicity, genotoxicity and uptake of gold nanoparticles in human HepG2 cells.An integrative test strategy for cancer hazard identification.An updated review of the genotoxicity of respirable crystalline silica.Epigenetic effects of carbon nanotubes in human monocytic cells Genotoxicity and Mutagenicity Testing of Biomaterials Nanotoxicology: Role of Physical and Chemical Characterization and RelatedIn Vitro,In Vivo, andIn SilicoMethods

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P2860

In vitro genotoxicity testing strategy for nanomaterials and the adaptation of current OECD guidelines

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J.MRGENTOX.2011.09.013

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Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice

Single-walled carbon nanotubes: geno- and cytotoxic effects in lung fibroblast V79 cells

The limits of testing particle-mediated oxidative stress in vitro in predicting diverse pathologies; relevance for testing of nanoparticles

Evidence that ultrafine titanium dioxide induces micronuclei and apoptosis in Syrian hamster embryo fibroblasts.

Dextran coated ultrafine superparamagnetic iron oxide nanoparticles: compatibility with common fluorometric and colorimetric dyes

Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties

Cytotoxicity and genotoxicity of silver nanoparticles in human cells

Monitoring of DNA damage in foundry and pottery workers exposed to silica by the alkaline comet assay.

In vivo genotoxicity assessment of aluminium oxide nanomaterials in rat peripheral blood cells using the comet assay and micronucleus test.

Soluble iron modulates iron oxide particle-induced inflammatory responses via prostaglandin E(2 )synthesis: In vitro and in vivo studies.

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