Genetic ablation of PLA2G6 in mice leads to cerebellar atrophy characterized by Purkinje cell loss and glial cell activation
about
New findings in a global approach to dissect the whole phenotype of PLA2G6 gene mutationsiPLA2β knockout mouse, a genetic model for progressive human motor disorders, develops age-related neuropathology.Calcium-independent phospholipases A2 and their roles in biological processes and diseases.Loss of PLA2G6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction.Impairment of PARK14-dependent Ca(2+) signalling is a novel determinant of Parkinson's diseaseDefective lipid metabolism in neurodegeneration with brain iron accumulation (NBIA) syndromes: not only a matter of iron.Neuroaxonal dystrophy in PLA2G6 knockout mice.Fast Progression of Cerebellar Atrophy in PLA2G6-Associated Infantile Neuronal Axonal Dystrophy.Mitochondrial dysfunction and defects in lipid homeostasis as therapeutic targets in neurodegeneration with brain iron accumulation.Mutations in the Drosophila homolog of human PLA2G6 give rise to age-dependent loss of psychomotor activity and neurodegeneration.Cytoskeleton stability is essential for the integrity of the cerebellum and its motor- and affective-related behaviors.
P2860
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P2860
Genetic ablation of PLA2G6 in mice leads to cerebellar atrophy characterized by Purkinje cell loss and glial cell activation
description
2011 nî lūn-bûn
@nan
2011 թուականին հրատարակուած գիտական յօդուած
@hyw
2011 թվականին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Genetic ablation of PLA2G6 in ...... loss and glial cell activation
@ast
Genetic ablation of PLA2G6 in ...... loss and glial cell activation
@en
Genetic ablation of PLA2G6 in ...... loss and glial cell activation
@nl
type
label
Genetic ablation of PLA2G6 in ...... loss and glial cell activation
@ast
Genetic ablation of PLA2G6 in ...... loss and glial cell activation
@en
Genetic ablation of PLA2G6 in ...... loss and glial cell activation
@nl
prefLabel
Genetic ablation of PLA2G6 in ...... loss and glial cell activation
@ast
Genetic ablation of PLA2G6 in ...... loss and glial cell activation
@en
Genetic ablation of PLA2G6 in ...... loss and glial cell activation
@nl
P2093
P2860
P1433
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Genetic ablation of PLA2G6 in ...... loss and glial cell activation
@en
P2093
Chunying Zhao
Zhengshan Zhao
Zhenyu Yue
Zhongmin Alex Ma
P2860
P304
P356
10.1371/JOURNAL.PONE.0026991
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P577
2011-01-01T00:00:00Z