A novel GTP-binding inhibitor, FX2149, attenuates LRRK2 toxicity in Parkinson's disease models
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Activation Mechanism of LRRK2 and Its Cellular Functions in Parkinson's DiseaseMitochondria: A Therapeutic Target for Parkinson's Disease?Protective LRRK2 R1398H Variant Enhances GTPase and Wnt Signaling Activity.The function of orthologues of the human Parkinson's disease gene LRRK2 across species: implications for disease modelling in preclinical research.Synphilin-1 attenuates mutant LRRK2-induced neurodegeneration in Parkinson's disease models.LRRK2 Kinase Inhibition as a Therapeutic Strategy for Parkinson's Disease, Where Do We Stand?GTP binding regulates cellular localization of Parkinson's disease-associated LRRK2.A High-Throughput Screen to Identify LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease Using RapidFire Mass Spectrometry.Mechanisms of LRRK2-dependent neurodegeneration: role of enzymatic activity and protein aggregation.Understanding the GTPase Activity of LRRK2: Regulation, Function, and Neurotoxicity.68 and FX2149 Attenuate Mutant LRRK2-R1441C-Induced Neural Transport Impairment.Leucine-rich repeat kinase 2 positively regulates inflammation and down-regulates NF-κB p50 signaling in cultured microglia cells.LRRK 2 gene mutations in the pathophysiology of the ROCO domain and therapeutic targets for Parkinson's disease: a review.
P2860
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P2860
A novel GTP-binding inhibitor, FX2149, attenuates LRRK2 toxicity in Parkinson's disease models
description
2015 nî lūn-bûn
@nan
2015 թուականին հրատարակուած գիտական յօդուած
@hyw
2015 թվականին հրատարակված գիտական հոդված
@hy
2015年の論文
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2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
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name
A novel GTP-binding inhibitor, ...... in Parkinson's disease models
@ast
A novel GTP-binding inhibitor, ...... in Parkinson's disease models
@en
A novel GTP-binding inhibitor, ...... in Parkinson's disease models
@nl
type
label
A novel GTP-binding inhibitor, ...... in Parkinson's disease models
@ast
A novel GTP-binding inhibitor, ...... in Parkinson's disease models
@en
A novel GTP-binding inhibitor, ...... in Parkinson's disease models
@nl
prefLabel
A novel GTP-binding inhibitor, ...... in Parkinson's disease models
@ast
A novel GTP-binding inhibitor, ...... in Parkinson's disease models
@en
A novel GTP-binding inhibitor, ...... in Parkinson's disease models
@nl
P2093
P2860
P3181
P1433
P1476
A novel GTP-binding inhibitor, ...... in Parkinson's disease models
@en
P2093
Dejun Yang
Fengtian Xue
Joseph M Thomas
Shijun Zhong
Tianxia Li
Wanli W Smith
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0122461
P407
P50
P577
2015-01-01T00:00:00Z